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J W Shands

Publications and source records attributed to J W Shands.

63 records · Page 4Linked to original sources
PubMed1968

Salmonellosis in mice infected with Mycobacterium tuberculosis BCG. I. Role of endotoxin in infection.

In agreement with previous observations, mice dying of salmonellosis were found to have a relatively constant number of Salmonella cells in their carcasses (ca. 5 x 10(9)). This number was not the result of bacterial overgrowth in moribund animals and therefore appears to be related to lethality. Similar numbers of salmonellae were recovered from the carcasses of infected mice which had previously been rendered hyperreactive to endotoxin either by infection with M. tuberculosis BCG or by adrenalectomy. In BCG mice, desensitization to endotoxin did not occur during the infection and, therefore, at death these mice contained a number of bacteria which would be equivalent to 1,000 ld(50) of endotoxin. Although the number of bacteria recovered from normal mice is roughly equivalent to a lethal quantity of endotoxin, this is obviously not the case in hyperreactive mice. Therefore, the relationship between lethality and 5 x 10(9) salmonellae cannot be explained by their endotoxin content. Nevertheless, when hyperreactive BCG mice are challenged parenterally with Salmonella, the endotoxin content of the inoculum may markedly influence the course of the infection.

Adrenalectomy↗
PubMed1965

Localization of Somatic Antigen on Gram-Negative Bacteria by Electron Microscopy.

Shands, J. W. (University of Florida, Gainesville). Localization of somatic antigen on gram-negative bacteria by electron microscopy. J. Bacteriol. 90:266-270. 1965.-Antisera specific for the somatic antigens of Salmonella typhimurium and Escherichia coli O113 were prepared, and globulins isolated from these antisera were labeled with ferritin. Micrographs of labeled, sectioned bacteria show that somatic antigen is located in considerable quantities on the surface of the bacteria, and, furthermore, that it can extend up to 150 mmu beyond the confines of the cell wall. The arrangement of the ferritin on the bacteria suggests that the antigenic sites are located on fibrillar structures.

Journal Article↗
PubMedDate not supplied

Histoplasmosis presenting as a neck mass.

A unilateral neck mass is an unusual clinical presentation for histoplasmosis. A patient with a large, unilateral neck mass caused by Histoplasma capsulatum is presented to alert readers to such a possibility and to illustrate some of the difficulties in diagnosing and managing the disease.

Aged↗