A critical study of isocarboxazid (Marplan) in the treatment of depressed patients.
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Biomedical subjects
Publications and source records attributed to J W Shaffer.
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Controlled laboratory data demonstrate biologic and mechanical characteristics of orthotopically placed canine ulnar autografts. The pattern of bone repair was similar in vascular and nonvascular ulnar grafts beginning with resorption followed by appositional reactive bone formation. The time intervals in the sequence were accelerated in the vascularized grafts. Both the strength and stiffness of the vascularized grafts were found to be significantly greater in Groups studied from six weeks to six months postoperation. There was no statistical difference between the grafts for mechanical testing performed on dogs either one week or one year postoperation. The vascularized ulnar bone grafts fared better than comparably sized nonvascularized grafts and were more rapidly repaired. The mechanical testing demonstrated superior strength and stiffness of the vascularized grafts throughout the repair process.
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Twelve canine rib transposition grafts were harvested and evaluated for preservation of subperiosteal and medullary canal blood flow using the hydrogen washout technique. Blood flow using hydrogen washout technique also was studied in the T11 vertebral body. The mean hydrogen washout blood flow was 0.201 ml/min/ml tissue for the subperiosteal rib measurement, 0.058 ml/min/ml tissue for a rib medullary measurement, and 0.085 ml/min/ml tissue for the vertebral body. The medullary canal hydrogen washout values were consistently less than the subperiosteal values. The results have demonstrated that the blood supply to the vascularized rib pedicle can be retained and quantitated in harvesting the rib graft using the hydrogen washout technique.