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Biomedical subjects

J W Rebuck

Publications and source records attributed to J W Rebuck.

At least 19 recordsLinked to original sources
PubMed1985

Signet ring cell lymphoma of the thyroid: a case report.

The first case of extranodal signet ring cell lymphoma involving the thyroid gland is reported in a 53-year-old woman with Hashimoto's thyroiditis. Since 1978, 24 cases of signet ring cell lymphoma, all involving primarily nodal tissue, have been documented in the literature. This rare neoplasm is believed to be a variant of non-Hodgkin's follicular lymphoma, which may be mistaken for metastatic poorly differentiated adenocarcinoma.

Adenocarcinoma↗
PubMed1983

Smoldering acute granulocytic leukemia. Observations on its natural history and morphologic characteristics.

In this prospective study, 24 patients with smoldering acute granulocytic leukemia received no specific treatment. Median survival duration from diagnosis was 9.29 months. Fourteen patients died of infection, four died of hemorrhage, two (8%) progressed to aggressive acute leukemia, and three remain alive at 36, 32, and 10 months. No survival predictions could be made from the severity of leukopenia, thrombocytopenia, or both. Neither sepsis nor hemorrhage, as causes of death, segregated into short- or long-term survivors (9.0 and 8.75 months' median survival, respectively). Thirteen patients (59%) had French, American, and British M2 subclassification of acute granulocytic leukemia. The following marrow findings distinguished this entity from preleukemia and other dysplastic states: clustering of stem cells; percentage usually between 20% and 40%; and Auer rods. The use of aggressive chemotherapy v only supportive measures in this condition remains unsolved.

Adult↗
PubMed1982

Lymphoma and the parotid gland.

The rich parotid lymphatic network makes necessary the inclusion of benign and malignant lymphoid disease in the differential diagnosis of parotid swelling. This area is affected directly by lymphoma in many clinical situations and has an indirect relationship with lymphoma through Sjögren's syndrome. These associations can produce uncertainty about the etiology and significance of parotid masses. Patients with Sjögren's have a spectrum of lymphoproliferative disorders from benign lymphoepithelial disease (BLD) to lymphoma and a significantly greater incidence of the latter than the general population. Nine patients with lymphoma and also benign and malignant lymphoid disease in the parotid illustrate various diagnostic considerations. These include that both benign and malignant parotid lymphoid pathology are seen with systemic lymphoma, that lymphoma can co-exist with BLD, may be misdiagnosed as BLD, and can develop in the same gland after appearance of BLD.

Adult↗
PubMed1982

The clinical significance of the morphological subdivision of diffuse "histiocytic" lymphoma: a study of 162 patients treated by the Southwest Oncology Group.

We grouped 162 patients wtih advanced, diffuse histiocytic lymphoma (DHL) into various morphological subtypes to ascertain whether there were any significant differences in survival among them. These patients were staged and treated from 1972 to 1977 according to the protocols of the Southwest Oncology Group. Of the 159 patients on whom a consensus on the diagnosis was reached, 115 were classified morphologically as having large non-cleaved, 26 as B-immunoblastic, 9 as large cleaved, and 6 as T-immunoblastic. The 3 remaining patients did not fit any of these subtypes, but each had a single prominent nucleolus in most tumor cells ("prominent nucleolus" type). Morphological subdivision of DHL did not identify any subgroup of patients with a significantly longer survival, but clinical parameters such as stage, symptoms, and type of treatment significantly influenced survival times.

Adolescent↗
PubMed1980

Type I dyserythropoietic anemia. A 30-year follow-up.

Dyserythropoietic anemias are extremely rare disorders which often are misdiagnosed as megaloblastic anemia, DiGuglielmo's syndrome, refractory sideroblastic anemia, paroxysmal nocturnal hemoglobinuria, or other hemolytic anemias. Dyserythropoietic anemia is now subclassified into four types, designated Types I through IV, depending upon light and ultrastructural morphology, erythrocyte immunology, and the course of the disease. This report details the findings in a case of Type I dyserythropoietic anemia that represented a puzzling case of anemia for over 30 years. Many modes of drug therapy, as well as splenectomy, were not helpful. Interestingly, the family history was non-contributory. A brief review of the literature dealing with dyserythropoietic anemia is included.

Adult↗
PubMed1977

Lymphoid follicles in bone marrow aspirates.

Lymphoid follicles were observed in 260 of 1,450 consecutive bone marrow aspirates (17.9%). As expected, the incidence of lymphoid follicles was less than those reported from autopsies (26.1-62.3%), but was twice as great as those in previous reports based upon study of aspirations (3.3-9.1%). The number of lymphoid follicles is also related to age and sex of the patient: they are rare in childhood and common after the fourth decade of life, particularly in women. Lymphoid follicles are found in higher incidence in bone marrow aspirates with plasma-cytosis and/or lipid granulomas than in those without these reactive changes. This relationship has not been described previously and suggests that the frequent occurrence of lymphoid follicles in the older age group may be a minifestation of a response to chronic immunologic stimulation.

Age Factors↗
PubMed1975

Fitzgerald factor: a hitherto unrecognised coagulation factor.

A newly recognised asymptomatic coagulation-factor deficiency is reported in a 71-year-old man. This factor seems to operate at an early stage in the intrinsic coagulation pathway and participates in other Hageman-factor-mediated biological reactions. The patient has an atypical cellular inflammatory response as observed by the skin-window technique.

Aged↗
PubMed1974

Hyperreactivity to cow's milk in an infant with LE and tart cell phenomenon.

LE and tart cells were demonstrated in a black male infant whose serum contained milk-percipitating antibodies and who had pulmonary infiltrates. Immunoblasts, plasmocytoid lymphocytes, and an LE cell were found in a milk-stimulated skin window. The presence of LE cells corresponded to the presence of ENA antibody. Tart cells varied with oral milk challenge. A large Arthus type of skin reaction to injected milk was demonstrated. An oral feeding of milk resulted in a decrease in plasma C3. Lymphocyte transformation resulted from in vitro milk stimulation. ENA (extractable nuclear antigen) antibody and resulting LE cell formation possibly represented the combination of nuclear protein with milk antigen. The pulmonary infiltrates may represent a hypersensitivity pneumonitis characterized by both Arthus and cell-mediated reaction to milk.

Animals↗