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Biomedical subjects

J W McCall

Publications and source records attributed to J W McCall.

80 records · Page 5Linked to original sources
PubMed1973

Comparative effects of 3-ethyl-8-methyl-1,3,8-triazabicyclo(4,4,0)decan-2-one and diethylcarbamazine against Litomosoides carinii in rodents.

3-Ethyl-8-methyl-1,3,8-triazabicyclo[4,4,0]decan-2-one and diethylcarbamazine were tested comparatively against Litomosoides carinii in Mongolian jirds and cotton rats. The drugs were compared in jirds by oral and by intraperitoneal administration. Comparisons in cotton rats were done by intraperitoneal administration. The drugs were given in a wide range of doses twice daily for 4 consecutive days. Parameters used for judging efficacy included the rate, degree, and duration of microfilaremia suppression as well as effects on adult worms. The two drugs exhibited similar strong but transient effect against microfilariae; neither drug had appreciable effect in killing adult worms.

Administration, Oral↗
PubMedDate not supplied

IgG response against infective larvae of Dirofilaria immitis in experimentally infected cats.

Somatic antigens from third stage larvae of Dirofilaria immitis (SL3) were used to detect IgG response against heartworm infection in 8 experimentally infected cats. A moderate specific anti-SL3 IgG response was found one month post-infection. Afterwards, antibodies decreased reaching a basal level 4 months post-infection and remained at this level until the end of the study. 6 months post-infection. Western blot analysis showed specific recognition of polypeptides of 79, 73, 60, 52, 40 and 39 kDa by sera from infected cats 1 month post-infection, but not by sera taken prior to the infection. The low antigenicity of the SL3 antigen in the cat should allow the parasite to escape the host's immune response.

Animals↗
PubMedDate not supplied

Survey of canine heartworm in the city of Recife, Pernambuco, Brazil.

Six hundred and eleven random-source dogs (338 male, 273 female) one year of age or older, from six sections of the city of Recife, Pernambuco, were examined antemortem for circulating microfilariae Dirofilaria immitis and Dipetalonema reconditum adult heartworm (D. immitis) antigen, and examined postmortem for adult heartworms. The prevalence of heartworm infection was 2.3% (14/611), as determined by necropsy for adult worms, and 1% (6/611) had circulating microfilariae of D. immitis; thus, 57.1% of the heartworm-infected dogs had occult infections. The results of serological testing indicated that 1.3% (8/611) of the dogs were positive for adult heartworm antigen. A total of 42 (6.9%) of the dogs had microfilariae of D. reconditum; 40 of these had only D. reconditum and two additional dogs had microfilariae of both species, D. immitis and D. reconditum.

Animals↗