The hazard of malarial nephropathy to the human race.
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Biomedical subjects
Publications and source records attributed to J W Kibukamusoke.
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Renal damage in malaria occurs as a result of two distinct mechanisms: microcirculatory disturbance, which is confined to falciparum malaria, and immunological damage through the deposition of soluble immune complexes. Quartan malarial nephropathy, due to Plasmodium malariae, is a progressive disease ending in chronic, hypertensive, renal failure. The disease seems most prevalent in adolescents, placing a heavy burden on the health services of developing countries where falciparum malaria is endemic.
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Ugandans with high malarial antibody titres have been found also to have higher IgM levels. Patients with active nephrotic syndrome have higher IgM and malarial antibody levels than both controls and nephrotics in remission, an extreme increase in these factors being found in patients in whom immune complexes were present.
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