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Biomedical subjects

J W Hickman

Publications and source records attributed to J W Hickman.

At least 19 recordsLinked to original sources
PubMed1985

Accidental hypothermia in a healthy quadriplegic patient.

An otherwise healthy 28-year-old quadriplegic patient was admitted to the hospital with a core temperature of 76 degrees F secondary to accidental hypothermia. Her neurologic disability was detrimental to thermoregulation by decreasing her ability to shiver actively and to vasoconstrict. The relationship between shivering and thermoregulation is discussed.

Accidents, Home↗
PubMed1980

Hypothermia in the sunny South.

Accidental hypothermia has increased in prevalence among the aged poor, probably because of a marked increase in heating costs. Most cases of accidental hypothermia in the past have been reported from either England or the northern United States. We report our experience with this disorder in the Tampa (Florida) General Hospital over the past five years. Different manifestations, treatment, and complications are reviewed.

Aged↗
PubMed1978

Cell-mediated cytotoxicity of desialylated human lymphocytes induced by a mitogenic mammalian liver protein.

The ability of a purified rabbit liver membrane protein that selectively binds desialylated glycoproteins to induce desialylated human peripheral blood lymphocytes to mediate mitogen-induced cellular cytotoxicity has been determined. After short term exposure to purified hepatic binding protein, desialylated, but not intact, lymphocytes exhibited mitogen-induced cellular cytotoxicity against Chang target cells, which do not have exposed hepatic binding protein on their surface membrane. Furthermore, desialylated lymphocytes, in the absence of purified hepatic binding protein, reduced the proportion of isolated rabbit hepatocytes that adhered to plastic to a significantly greater extent than did intact lymphocytes, suggesting that the exposed hepatic binding protein demonstrated on the surface membrane of these target cells is capable of inducing mitogen-induced cellular cytotoxicity. The specific inhibition of this effect by asialo-orosomucoid, but not by intact orosomucoid, indicates that the site involved in the binding of asialo-glycoproteins to hepatic binding protein is probably also responsible for the induction of mitogen-induced cellular cytoxocity. The demonstration that hepatic binding protein, a normal constituent of the surface, membrane of mammalian hepatocytes, can induce mitogen-induced cellular cytotoxicity, suggests that mitogen-induced cellular cytotoxicity may be a mechanism of cellular injury in vivo.

Animals↗
PubMed1977

Nonthyropathic exophthalmos.

Although most cases of bilateral exophthalmos and many cases of unilateral exophthalmos are related to hyperthyroidism, there are numerous other diagnostic possibilities. These include tumors, hemorrhage, vascular anomalies and infections. Exophthalmometric measurements are useful in diagnosis and follow-up. The determination of a nonthyroidal etiology for exophthalmos may require sophisticated radiologic and other techniques, as well as a team approach.

Exophthalmos↗
PubMed1975

Hemolytic anemia and thrombocytopenia associated with penicillamine ingestion.

A case of a 52-year-old white woman who developed hemolytic anemia and thrombocytopenia after receiving D-penicillamine is presented. Although there appears to be a causative relationship, it cannot be documented at this time. No other case of hemolysis has been suggested in patients treated with penicillamine. Since penicillamine is being used more frequently and in an ever-growing list of conditions, it is advisable to be alert to the possibility of hemolytic anemia as another of the complications of therapy.

Anemia, Hemolytic↗