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Biomedical subjects

J W Hazell

Publications and source records attributed to J W Hazell.

9 recordsLinked to original sources

Positional audiometry in the diagnosis of perilymphatic fistula.

Fifty-eight cases with a presumptive clinical diagnosis of perilymphatic fistula (PLF) are described with the results of a positional audiometric test designed to detect the presence of air in the cochlea. All patients underwent tympanotomy and observations of the middle ear are recorded together with the results of treatment. A definite leak was found in 33 cases and none in 25, but grafting of the round and oval window was performed in all but 10 cases. Pure-tone audiometry was performed before and after a 30-minute period of positioning the patient horizontally with the affected ear uppermost. A change in audiometric thresholds was noted in the group where a presumptive diagnosis of PLF was made, including some of those not found to have leaks at operation. However these changes were not observed in the positional tests of a group of 22 patients with hearing losses attributable to other causes. Also, an abnormal air-bone gap was noted in the PLF group compared with the other group. Although the original two-frequency criteria of earlier studies applied to the positional test did not predict the operative findings (leak or no leak), new data on frequency specific changes are presented. It is possible that fistulas at the oval window may be associated with positional threshold change at 500 Hz, and those at the round window with changes at 8 kHz.

Audiometry, Pure-Tone

Tinnitus. I: Auditory mechanisms: a model for tinnitus and hearing impairment.

A model is proposed for tinnitus and sensorineural hearing loss involving cochlear pathology. As tinnitus is defined as a cortical perception of sound in the absence of an appropriate external stimulus it must result from a generator in the auditory system which undergoes extensive auditory processing before it is perceived. The concept of spatial nonlinearity in the cochlea is presented as a cause of tinnitus generation controlled by the efferents. Various clinical presentations of tinnitus and the way in which they respond to changes in the environment are discussed with respect to this control mechanism. The concept of auditory retraining as part of the habituation process, and interaction with the prefrontal cortex and limbic system is presented as a central model which emphasizes the importance of the emotional significance and meaning of tinnitus.

Auditory Pathways

Tinnitus. III: The practical management of sensorineural tinnitus.

A weekly tinnitus clinic at University College Hospital, London, has been in existence since 1976. By developing a holistic and multidisciplinary approach to the management of tinnitus, we have been able to help the majority of patients referred with severe and disabling tinnitus. We have developed a protocol for the clinical assessment of tinnitus as a disability, and a strategy of investigation and reassurance based on the patient's understanding of the underlying mechanisms involved in tinnitus generation. Most treatment is aimed at bringing about a process of habituation (which occurs naturally in the majority of people experiencing tinnitus over a period of time). Symptom control is required in about half the patients referred, and various techniques are discussed including prosthetic masking devices, psychological approaches, drug therapy and electrical tinnitus suppression.

Combined Modality Therapy

Tinnitus. II: Surgical management of conditions associated with tinnitus and somatosounds.

The literature relating to the effects of otological surgery on tinnitus is reviewed. The results of such surgery are often unpredictable with respect to postoperative tinnitus, and ablative surgery may well make the tinnitus worse. The concept of somatosounds (tinnitus arising from outside the auditory pathway) is presented, and the management of some conditions, including patulous Eustachian tube and palatal myoclonus, is discussed.

Deafness

Tinnitus.

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Aspirin

The post-auricular myogenic response: a new instrument which simplifies its detection by machine scoring.

A portable apparatus is described which can be used for routine audiometric screening in a children's clinic. The apparatus measures the postauricular myogenic response to click stimuli and the design of the machine makes for great simplicity of operation. A simple form of machine scoring is employed so that a completely objective result is obtained. Evaluating the equipment on 102 subjects produced no false positive results, but a small percentage of normally hearing adults and children failed to produce a response. The equipment was successfully evaluated in a routine audiometric screening situation on 46 babies aged 6 to 9 months.

Adult

Electrical stimulation of the human cochlea using a transtympanic electrode.

Thirteen patients received stimulation of the cochlea using a transtympanic electrode. The purpose was to investigate the effect of alternating current on the normal and the damaged cochlea and also to discover what effect, if any, it has on tinnitus. Measurements were made of the electrical dynamic range and in one case a loudness balance test was performed against an acoustic signal in the contralateral ear. In addition nine patients experienced a variety of somatic sensations and four had vertigo. Tinnitus was temporarily suppressed in two out of nine cases.

Cochlea

E.N.T. complications in thalassaemia major.

Twenty-six cases of thalassaemia major have been investigated for E.N.T. complications. Twelve (46 percent) had significantly problems requiring surgery. Since the prognosis of the disease is improving dramatically, these patients should not be denied treatment. bony hypertrophy of the turbinates was a noticeable feature in the untreated group and does not seem to have been described before.

Adolescent