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Biomedical subjects

J W Frame

Publications and source records attributed to J W Frame.

At least 91 records · Page 5Linked to original sources
PubMed1984

The effects of the carbon dioxide surgical laser on oral tissues.

The carbon dioxide laser has become more widely available in recent years and is now employed in many branches of surgery. It is important to understand its biological effect on oral tissues so that the likely response in patients can be predicted. However, little information has been published on the healing mechanism of oral wounds. A study of the healing of laser wounds at various sites in the mouth has been undertaken in a clinically analogous animal model and the results correlated with the findings in patients. A brief description is given of the role of the carbon dioxide laser in the management of oral mucosal disease.

Animals↗
PubMed1984

Civilian maxillo-facial gunshot injuries.

Recently, in many parts of the world, there has been an increase in the number of civilian crimes involving guns and nowadays any oral surgeon in hospital may be confronted with this type of injury. This paper reviews the mechanism of wounding by different firearms to allow an appreciation of their effect on living tissues, and then outlines the clinical management of these injuries.

Facial Bones↗
PubMed1983

A comparative histological study of wound healing following CO2 laser and conventional surgical excision of canine buccal mucosa.

The histological changes following removal of 2 cm discs of buccal mucosa by CO2 laser and conventional surgery were studied over a period of 42 days. The laser wound differed from the conventional wound: there was minimal damage to the adjacent tissue; initially a coagulum of denatured protein formed on the surface; the inflammatory reaction was less; fewer myofibroblasts were present and there was little wound contraction; less collagen was formed and epithelial regeneration was delayed and more irregular.

Animals↗
PubMed1983

A radio-isotope study of the healing of mandibular bone grafts in patients.

Radionucleotide scanning is now accepted as a reliable method of visualising the metabolic activity of the skeletal system. Its application to the maxillo-facial region is reviewed, and its possible role in monitoring the healing of bone grafts is discussed. The radio-isotope 99m technetium-methylene diphosphonate was used to study the revascularisation and healing of large autogenous bone grafts to the mandible in eight patients. The scans demonstrated the dynamic activity in the grafts and showed varying patterns in different types of grafts.

Bone Transplantation↗
PubMed1982

Biologic basis for interpositional autogenous bone grafts to the mandible.

Interpositional autogenous bone grafting procedures were performed in the mandibles of 12 beagle dogs to assess cell survival within the graft and the superiorly repositioned alveolus, and to monitor the remodeling process. Histologic and radiologic results indicated that the grafts were well accepted and that new bone was rapidly laid down on their trabeculae. However, the osteocytes within the autografts generally did not survive. There was no evidence of necrosis of the superiorly displaced alveolus, nor any resorption of its surface cortex, and it rapidly united with the autograft and the mandible to produce a stable structure. This study confirms that the lingual pedicle of soft tissue is adequate to maintain the viability of the superiorly repositioned alveolus or segment and to allow rapid remodeling of the autogenous bone graft.

Animals↗
PubMed1981

The value of computerized tomography in oral surgery.

Computerized tomography is known to be of value in the assessment of malignant tumors of the head and neck. In addition, it can be helpful in the diagnosis of maxillofacial injuries, especially of the midface, and blowout fractures of the orbital walls. The present article reviews its possible role in the management of patients with expanding and infiltrating lesions of the jaws. An important feature of the technique is that soft tissues can be clearly demarcated from the surrounding structures. In addition, views are possible in both axial and coronal planes. Since 1977, CT has been employed in more than twenty patients with benign or locally invasive jaw lesions and has demonstrated a high degree of accuracy. However, a much larger series is necessary to assess the reliability of the technique and to define its role in the preoperative investigation of patients with this type of problem.

Child↗
PubMed1981

Hydroxyapatite as a bone substitute in the jaws.

Densely sintered calcium hydroxyapatite has previously been shown to be biocompatible and stable. Its possible role in jaw surgery was investigated using a clinically analogous animal model. The apatite was implanted into the mandible of twelve dogs for 12 weeks, and the healing assessed radiologically and histologically. The new bone which was deposited directly onto the surface of the implants bonded them firmly to the adjacent tissues. There was no fibrous tissue between implant and bone. This material appears to be a suitable substitute for autogenous bone when used as inert 'space filler' in maxillo-facial surgical procedures.

Animals↗
PubMed1981

Augmentation of the edentulous mandible using bone and hydroxyapatite: a comparative study in dogs.

This study compared autogenous bone, freeze-dried homografts, and hydroxyapatite in interpositional grafting of the mandible in beagle dogs. Healing was assessed radiologically and histologically. Results showed that the rate of incorporation of the autografts was greater than that of the homografts, and at both 4 and 12 weeks healing was more advanced. There was also rapid healing around the hydroxyapatite grafts, which became firmly bonded to the surrounding bone. The apatite was not resorbed, and new trabeculae of bone had been deposited onto much of its surface. This investigation confirms that hydroxyapatite is well tolerated and may be a suitable substitute for autogenous bone for augmentation of the atrophic mandible.

Alveolar Ridge Augmentation↗
PubMed1980

A convenient animal model for testing bone substitute materials.

There is consijerable interest in developing substitute materials for bone to perform the functions of autogenous bone grafts. However, a persistent problem is finding a suitable animal model in which to test the biodegradable implants. This paper reviews the requirements of an ideal animal model for this purpose and discusses the shortcomings of existing procedures. A technique is described that uses the cranial vault of the rabbit and allows accurate radiologic and histologic assessment of implant resorption and ingrowth of new bone.

Animals↗