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Biomedical subjects

J W Daniel

Publications and source records attributed to J W Daniel.

At least 37 records · Page 2Linked to original sources
PubMed1972

The metabolism of phenylmercury by the rat.

The metabolism of [U-(14)C]phenylmercury acetate was studied in the rat. After a single subcutaneous dose a small proportion is excreted unchanged in urine, and a larger amount in bile with some resorption from the gut. The greater part of the dose is broken down in the tissues to yield inorganic mercury which is excreted mainly in faeces, and conjugates of phenol and quinol are excreted in urine. In experiments in vitro phenylmercury is broken down by liver homogenates to release inorganic mercury and benzene; this reaction is effected by the soluble, but not the microsomal, fraction and does not require NADPH or NADH. No elemental mercury is formed under these conditions. It is probable that this reaction occurs in vivo and the benzene produced is rapidly converted into phenol and quinol by microsomal enzymes.

Animals↗
PubMed1971

Factors influencing return to work.

Seventy-seven patients with severe brachial plexus injuries were interviewed two or more years later to determine their success in returning to work and the factors that had led to good or bad resettlement. For most of them these were crucial issues potentially influencing the rest of their lives. When interviewed virtually all had regular jobs in open industry, but many had endured long delays and most were working entirely one-handed. Failure of communication was regrettably common. Too often advice by doctors had been lacking, and there was evidence that the services for vocational resettlement could be improved.

Accidents, Traffic↗
PubMed1971

The metabolism of methoxyethylmercury salts.

The metabolism of methoxy[(14)C]ethylmercury chloride in the rat has been investigated. After a single subcutaneous dose a small proportion is excreted unchanged in urine and a larger amount in bile with some resorption from the gut. The greater part of the dose is rapidly broken down in the tissues with a half-time of about 1 day to yield ethylene and inorganic mercury. Ethylene is exhaled in the breath and the mercury migrates to the kidney and is excreted in urine. A small proportion of the dose appears as carbon dioxide in the breath and about 12% in urine as a mercury-free metabolite. It is possible that the breakdown of methoxyethylmercurychloride to ethylene and inorganic mercury is not catalysed by an enzyme system.

Animals↗
PubMed1969

Return to work: experiences of a hospital rehabilitation officer.

Successful return to work after illness or injury often depends on an efficient exchange of information between doctor and employer. Rehabilitation officers with experience in industry have been employed by the Royal National Orthopaedic Hospital, Stanmore, for several years and have established their value in acting as direct links between hospital and industry.

Adult↗