Biomedical subjects

J W Craig

Publications and source records attributed to J W Craig.

At least 37 records · Page 2Linked to original sources

PubMed1976

Virulence for man of a human influenza-A virus antigenically similar to "classical" swine viruses.

The newly isolated human influenza-A strain containing swine antigens isolated in New Jersey, U.S.A., was inoculated into six volunteers. Clinical reactions were mild although all volunteers were infected. The longest period for which the virus was excreted was 8 days and the shortest 3 days. In its virulence for man the New Jersey strain was intermediate between a human and animal virus, and was quite clearly more virulent than known swine viruses. It seems possible that the outbreak in the U.S.A. was an isolated event and that the virus will not become established in man.

Antibodies, Viral↗

PubMed1976

Four compounds active against rhinovirus: comparison in vitro and in volunteers.

Four unrelated compounds active against rhinovirus were compared in tissue culture, and three of them were used in volunteers challenged with rhinovirus. The compounds were the triazino-indole SKF 40491, the substituted oxadiazole GLR9-338, the imidazo-thiazole RP L9326, and the guanidine derivative ICI 73,602. The abilities of these compounds to reduce the yield of rhinovirus types 3, 4, 9, and 31 from HeLa cells or fibroblasts were compared, and a sensitive serotype was chosen for each challenge experiment in humans. In doubleblind studies volunteers received intranasal medication before and after the challenge. Daily scoring of symptoms and titration of virus in nasal washings showed that subjects treated with SKF, GL, and RP all shed less virus than their corresponding placebo groups, significantly so in the cases of GL and RP. Clinical reactions were also less severe in volunteers treated with RP.

Adolescent↗

PubMed1975

Trials in man with live recombinants made from A/PR/8/34 (H0 N1) and wild H3 N2 influenza viruses.

A long-term study is described of recombinant influenza viruses produced from the avirulent laboratory strain, A/PR/8/34 (H0 N1), and newly isolated H3 N2 influenza virus variants. A number of H3 H2 recombinants were found to be attenuated for man and capable of inducing antibody formation, and were therefore potentially usable as live vaccines. However, the volunteer trials as a whole suggested that, in this system, there might not be complete segregation of virulence and antigenic characteristics. No H3 N2 recombinants were detected which were non-infective for man, like the A/PR8 (H0 N1) parent, and reciprocal hybrids (H3 N1 and H0 N2) always reflected some of the virulence of the parent from which they had inherited their haemagglutinin. This property is not a feature of mouse influenza.

Animals↗

PubMed1975