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Biomedical subjects

J W Albers

Publications and source records attributed to J W Albers.

10 recordsLinked to original sources
PubMed1979

Computed tomography in Behçet disease.

In Behçet disease, CT may demonstrate low attenuation mass lesions with or without contrast enhancement. Since neurologic involvement may precede the typical dermatologic manifestations, Behçet disease should be included in the differential diagnosis of intracranial mass lesions. A case is presented with central nervous system involvement.

Adult↗
PubMed1978

Phase II study of metronidazole therapy for advanced colorectal carcinoma.

Thirty-two patients with advanced carcinoma of the colon or rectum were given metronidazole orally at a dose of 500-1000 mg/m2 three times a day for 7 consecutive days every 6 weeks. The dose-limiting toxic effects consisted of severe nausea, vomiting, and major motor seizures. Mild peripheral neurotoxic effects were also noted. No objective responses were noted in any of the 32 patients treated. High-dose metronidazole would not seem to have any role in the treatment of advanced colorectal carcinoma and may cause serious neurotoxicity.

Adult↗
PubMed1977

Measurements of autonomic function before, during, and after transcutaneous stimulation in patients with chronic pain and in control subjects.

Transcutaneous stimulation (TCS) has been reported to modify peripheral blood flow, skin temperature, blood pressure, and heart rate, all of which are under the influence of the autonomic nervous system (ANS). In 20 patients with intractable pain and in 10 control subjects, TCS was not found to alter significantly any of the observed properties of ANS function of control subjects or patients, except to decrease skin impedance in the patient group after the stimulation. Patients reporting pain relief during TCS were found to have significantly higher systolic blood pressure under all test conditions than patients reporting no pain relief (p less than 0.05). No other significant differences were found between these two groups. Finally, in the patients, no significant localized autonomic changes were demonstrated in the painful area by comparison with the homologous body part.

Adult↗
PubMed1975

Summated auditory evoked potentials in the cerebellum and inferior colliculus in the young rat.

The summated auditory evoked responses recorded at the superior surface and depth of the cerebellum of the young rat had a similar latency and configuration as did summated auditory evoked potentials in the inferior colliculus. Electric stimulation of the inferior colliculus did not evoke a response (other than the shock-artifact response) at the cerebellum. Stimulation of the cerebellum did not modify the evoked responses to click in the inferior colliculus (unless current levels were large enough to cause current spread to the brain stem). There is insufficient evidence to conclude that the cerebellum has an auditory receiving area in the young rat.

Animals↗
PubMed1975

Validity of quantitative tests measuring tremor.

A set of tests measuring tremor with an accelerometer has been developed to assist in objectively evaluating clinical trails. An experiment was designed to examine the consensual validity of the test measures for Resting, Sustention and Static Intention Tremor for 10 multiple sclerosis patients and 10 parkinsonian patients. Motion pictures of the patients performing the tremor tests were viewed by a senior neurologist who rated tremor using a nine-point ordinal scale. Comparisons made between the quantitative measures of tremor and the neurologist's ratings of tremor show that the tests are consensually valid. The methodology of this experiment may prove useful for examining in the future the consensual validity of new clinical instruments useful for evaluating trails.

Age Factors↗
PubMedDate not supplied

Electrodiagnostic findings in acute porphyric neuropathy.

Of 115 patients with acute intermittent porphyria seen during a 20-year period, 11 had experienced an acute episode of quadriparesis. Nerve conduction studies performed on 8 of these 11 patients showed low-amplitude compound action potentials and normal velocity measurements. Needle electromyography demonstrated prominent fibrillation potentials, especially in proximal muscles. The changes in these findings with time confirm that this disorder is an acute axonal neuropathy.

Action Potentials↗