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Biomedical subjects

J Vreeken

Publications and source records attributed to J Vreeken.

At least 55 records · Page 3Linked to original sources
PubMed1978

Haemostatic defect in non-immune patients with falciparum malaria: no evidence of diffuse intravascular coagulation.

Nine non-immune patients with imported falciparum malaria were examined for signs of diffuse intravascular coagulation (DIC). Although all had thrombocytopenia initially and some later had a decline in plasma fibrinogen concentrations, DIC was never detected, even in severely affected patients with coma and kidney damage. None of the patients were given heparin and all recovered without residual symptoms. Heparin administration should probably be considered only when clear-cut DIC, which possibly never occurs in falciparum malaria, has been demonstrated.

Blood Coagulation Tests↗
PubMed1977

Rebound thrombocytosis after alcohol abuse: a possible factor in the pathogenesis of thromboembolic disease.

Five alcoholic patients had rebound thrombocytosis after withdrawal of alcohol. This rebound thrombocytosis was not always preceded by thrombocytopenia at admission. Two patients had a history of unexplained recurrent venous thrombosis and recurrent pulmonary embolism. It is suggested that recurrent rebound thrombocytosis after alcohol abuse can be a factor in the pathogenesis of thromboembolic disease in some patients.

Adult↗
PubMed1977

Stimulation of monocyte procoagulant activity by adherence to different surfaces.

During in vitro incubation for several hours human circulating blood leucocytes developed procoagulant activity (PCA) which was identified as tissue thromboplastin-like activity and which remained specifically associated with monocytes. Adherence of monocytes to glass stimulated these cells to generate PCA. When cuprophane was used, both the degree of adherence of monocytes and PCA generation by these cells was significantly less. In addition, when the monocytes were incubated upon a monolayer of cultured endothelial cells only minor PCA generation was detectable. After incubation on glass the non-adherent monocytes had negligible PCA in comparison to the adherent monocytes. Protein synthesis inhibitors (cycloheximide and actinomycin D) inhibited PCA generation but did not affect monocyte adherence. These results demonstrate that adherence of monocytes is a stimulus for the generation of PCA.

Blood Coagulation↗
PubMed1976

Plasmin inactivation in plasma.

Inhibition and inactivation of plasmin is ascribed to alpha2-macroglobulin, alpha1-antitrypsin and c1-esterase inhibitor. In an "overall" inactivation test of plasmin in plasma, which comes perhaps closest to rapid inactivation of plasmin in the circulating blood, we only found a correlation between the immunological concentration of alpha2-macroglobulin and the plasmin-inactivating capacity of the plasma, but no correlation with the immunological concentration of the other inhibitors mentioned. Therefore, alpha2-macroglobulin seems to be the most important plasmin inhibitor in relation to thrombosis.

Blood Coagulation Tests↗
PubMed1975

Effect of low-dose heparin on incidence of postoperative thrombosis in orthopaedic patients.

In a double-blind study, using matched controls, thrombo-embolic prophylaxis with subcutaneous low-dose heparin was studied in 25 patients admitted for orthopaedic surgery. Deep vein thrombosis (DVT) was detected by clinical assessment and by the 125I-fibrinogen leg-scanning technique. As a control the T-1/2 of the 125I-fibrinogen was measured. Six of the 13 patients in the control group and one in the heparin-treated group developed deep vein thrombosis within the first eight postoperative days.

Aged↗