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Biomedical subjects

J Vollmar

Publications and source records attributed to J Vollmar.

156 records · Page 9Linked to original sources
PubMedDate not supplied

Guar and its effects on metabolic control in type II diabetic subjects.

The effect of guar mini-tablets (5 g t.i.d.) on carbohydrate and lipid metabolism of outpatients with overt diabetes mellitus with glycosuria (is greater than 5 g/24 h) was determined in an open-controlled, randomized, multicenter, crossover study. A 4-wk pretreatment period was followed by a 6-wk treatment period. The treatment period consisted of a 2-wk guar period (treatment period II), which was followed by the wash-out period. The other half of the patients received treatment in the reverse order. Out of 93 patient records, 79 (41 sulfonylurea [SU] and 38 insulin-treated) were suitable for statistical analysis. No relevant weight-reducing effect of guar could be found in both 2-wk treatment periods. At the end of treatment period II, the lowering of the 1-h postprandial values of blood glucose (SU 12%, insulin 10%), cholesterol (SU and insulin 25%) was significant after 2-wk of guar treatment compared with the wash-out period. No clinically relevant changes in the safety laboratory parameters were observed during guar treatment. Side effects were observed in 40 of the 93 patients included in the trial. Treatment had to be discontinued in 11% of the patients due to gastrointestinal side effects. On the basis of our results,guar treatment in combination with sulfonylurea and insulin can be recommended for the improvement of carbohydrate and lipid metabolism.

Clinical Trials as Topic↗
PubMedDate not supplied

Thoracic outlet-syndrome with vascular complications.

1. In thoracic outlet-syndrome arterial lesions--such as poststenotic aneurysm with or without peripheral arterial emboli--are mostly caused by permanent compression of the vessel. In 48% of cases arterial emboli show to be the first clinical manifestation of a subclavian artery lesion. 2. Venous lesions usually classified as "spontaneous axillar vein thrombosis" are probably initiated by intimal lesions of the axillary vein caused by compressionof this vessel in the costoclavicular space. 3. Unilateral ischemia of fingers or hand--especially in young patients--should be considered first of all as a peripheral manifestation of a cervical rib-syndrome. Surgical correction should include besides rib resection, lumen control of the poststenotic dilated artery, disobliteration of occluded main arteries and thoracic sympathectomy in cases with several distal arterial embolic occlusions. 4. Venous thrombectomy for acute thrombosis of the axillary and subclavian vein should be combined with the resection of the first rib in order to prevent any further compression to the vein in the costoclavicular space. The use of a temporary a.v.-fistula may be used as an additional mens for keeping the disobliterated vein patent. 5. In the thoracic outlet-syndrome neurological signs and complaints caused by intermittent or permanent mechanical nerve irritation represent the most frequent clinical findings (i.e. 90%). On the other hand in two thirds of patients with arterial or venous complications neurological signs are missed and therefore do no help for diagnosis.

Adult↗