[Effect of the combined administration of guar-bezafibrate on lipid, apolipoprotein and lipoprotein in patients with primary hyperlipoproteinemia type II].
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
J Vollmar
Publications and source records attributed to J Vollmar.
[Improvement in diabetes control by treatment with bezafibrate].
380 diabetic patients with hyperlipidaemia and undergoing treatment with sulphonylureas or insulin were given 200 mg bezafibrate t.i.d for 3 months after a control period of 4 weeks. After cessation of treatment a follow-up examination was performed a further 4 weeks later. 194 treatment centres took part in the investigation. Total cholesterol fell by 17%, triglycerides by 36% and HDL-cholesterol rose by 15% during the treatment period. In addition, a glucose-lowering effect was seen which led to a definite improvement in the control of diabetes both with glibenclamide and with insulin. The degree of glucose reduction was most marked in moderately or poorly controlled diabetics. There was no correlation between the triglyceride reduction and the glucose reduction. After cessation of bezafibrate treatment the cholesterol, triglyceride and fasting glucose increased again and the HDL-cholesterol diminished. However, they did not reach pretreatment values. Bezafibrate was well tolerated, hypoglycaemia or hypoglycaemic reactions were not observed.
Aged↗
Fatty acid composition of adipose tissue, blood, lipids, and glucose tolerance in patients with different degrees of angiographically documented coronary arteriosclerosis.
Forty-eight patients with symptoms of angina pectoris were studied for adipose tissue fatty acid composition and cardiovascular risk factors while hospitalized for selective coronary angiography. Patients with manifest diabetes mellitus and deviations form the "normal" customary diet were excluded. Pairwise comparison between the groups with absent, slight, moderate, and severe coronary arteriosclerosis showed reasonable comparability for age, relative body weight, and skinfold measurements. The proportion of smokers, but not of hypertensives, showed a significant positive relationship with the degree of arteriosclerosis. Serum cholesterol was similar in all four groups, while triglycerides were clearly, but not significantly (P greater than 0.05) higher in patients with coronary arteriosclerosis. The oral glucose tolerance test (OGTT) index was significantly higher in moderate and severe disease. Significantly higher proportions for palmitic acid lower proportions for linoleic acid were also found in these two groups. Multiple linear regression analysis showed a positive association with coronary arteriosclerosis for: OGTT index greater than palmitic acid greater than arachidonic acid greater than triglycerides. The close negative association between the proportion of stearic acid in adipose tissue and coronary heart disease observed in two previous studies could not be confirmed. On the basis of the present study, stearic acid correlates with age rather than with arteriosclerotic disease.
Adipose Tissue↗
Bezafibrate: lack of effect on creatinine excretion and muscular proteins.
The effect of bezafibrate (200 mg t.i.d.) on renal and, to some degree, on muscular function was studied in nine patients with primary hyperlipoproteinemia. No signs of a reduction in creatinine excretion or an increase in muscular proteins could be found serving as a possible explanation for the slight increase in serum creatinine observed in a bezafibrate long-term study in more than 1,000 patients. Further studies are necessary for clarification.
Bezafibrate↗
[Chronic intestinal circulatory insufficiency].
Explore the source record for details and available documents.
Age Factors↗
[The effect of bezafibrate on biliary lipids (author's transl)].
The effect of bezafibrate (3 x 200 mg/day) on biliary lipids was studied in 12 healthy male subjects and in 13 patients with hyperlipidemias. In normal subjects, the lithogenic index, with bezafibrate and placebo administered in a double blind cross-over design, was 1.1 and 0.77 respectively. The difference was not significant. In patients, who have been treated with bezafibrate for 6 months to 3 years the index was 0.76, and 0.64 six weeks after discontinuation of the drug. This difference, too, was not significant. It appears, therefore, that contrary to findings with clofibrate, bezafibrate may not be associated with an increased risk of cholelithiasis. This question, however, can ultimately be answered with certainty only on the basis of long-time epidemiologic evidence.
Adult↗
[The transverse crossover bypass of the pelvic veins (the "high Palma")].
Explore the source record for details and available documents.
Adult↗
[Reinterventions for recurrent occlusions (pelvic and leg arteries)].
Explore the source record for details and available documents.
Amputation, Surgical↗
[Effect of antihypertensive drug combination therapy on the metabolism in diabetics].
Explore the source record for details and available documents.
Aged↗
[Aneurysm of the infrarenal abdominal aorta].
The experience with 125 consecutive patients who underwent operations for infrarenal aortic aneurysm is presented. Two intervals of four years each were reviewed and compared: period A (1970-1974) and period B (1975-1978). With a simpler and shorter technique (dissection method), and more frequent operations (+72%), the operative mortality in cases of nonruptured aneurysms decreased from 14.3% (A) to 2,1% (B); in cases of ruptured aneurysms, from 61,1% (A) to 48,4% (B). In cases of elective operation there was no significant correlation of mortality to age, concomitant coronary disease (52,5%), and occlusive disease of peripheral vessels. The improved results are due to simplification and standardization of operative procedures and to use of efficient intensive care possibilities.
Age Factors↗
Principles of operation for combined aortoiliac and femoropopliteal occlusive lesions.
In combined chronic occlusive lesions at the aortoiliac and femoropopliteal level, partial repair of the central vessels in combination with profundaplasty and lumbar sympathectomy represents a more simple and shorter procedure than does the previously preferred total correction of both segments. In a retrospective study of 403 limbs, Stages II, III and IV, the triad procedure results in a cumulative patency rate of 77 versus 39 percent for total repair. In limb salvage operations, Stages III and IV, the corresponding figures for the amputation rate were 8 versus 36 per cent and for reoperation, 7 versus 23 per cent. Prerequisites for this type of repair are an improved technical approach and a critical selection of patients with a receiving segment of the popliteal artery and a sufficient runoff below the knee.
Aorta↗
[Vascular replacement with plastics (author's transl)].
The plastic substitution of the aorta and its large branches may be considered largely solved today. For this purpose preference is given to highly porous, thin-walled double velour prostheses. The search for a biocompatible plastic substitute for small caliber arteries and the large veins of the body (portal vein, vena cava, iliac veins) is proceeding in two directions at the present time: on the one hand towards optimized bioprostheses and on the other hand towards plastics which apply the principle of microporosity or impermeability with the creation of antithrombogenic inner surfaces. In this respect expanded polytetrafluoroethylene and coating with carbon are very promising.
Biocompatible Materials↗
[The effect of metipranolol on the carbohydrate metabolism in diabetics treated with glibenclamide (author's transl)].
Previous investigations on the effect of beta-receptor blockers on the carbohydrate metabolism of diabetics have reported varying effects, the most frequent being hypoglycaemic symptoms which were interpreted as potentiating effects caused by interference with the antidiabetic agents. For this reason, the effect of the beta-receptor blocker metipranolol on the carbohydrate metabolism of diabetics treated with glibenclamide was investigated in a double blind cross-over study comparing metipranolol with placebo. The results do not show any significant difference between the placebo and the metipranolol with respect to the blood or urinary sugar values or the plasma insulin levels. Whether or not this is a substance-specific property needs to be clarified by further comparative investigations using other beta-receptor blockers. There were similarly no significant differences in the most important parameters of hepatic and renal function.
Adult↗
[Reconstructive surgery of the internal carotid artery (author's transl)].
Between 1970 and 1978 we performed 403 endarterectomies of the internal carotid artery on 330 patients. Operative morbidity (and mortality) depended on the severity of the ischemic cerebral damage at the time of the operation: stage I (137 operations):1.5% (0.7%); stage II (134 operations): 2.2% (3.7%); stage III (29 operations): 3.4% (10.3%); stage IV (103 operations): 3.9% (7.8%). According to the life-table analysis (average follow-up: 40 months) the rate of cured or improved patients amounts to 94% (operated at stage I), 85% (stage II), 84% (stage III) and 70% (stage IV).
Arterial Occlusive Diseases↗
[Surgical treatment of cerebrovascular insufficiency].
Explore the source record for details and available documents.
Anticoagulants↗
[Expanded PTFE (polytetrafluoroethylene) vascular prostheses--a new path of arterial and venous replacement].
Based on existing experimental and clinical observations the expanded PTFE graft shows convincing advantages in some indication fields (e.g., vascular access for hemodialysis, venous reconstruction) compared with conventional porous prostheses and biografts. On the other hand, we have to realize that expanded PTFE is not yet qualified to be the optimal substitute for small arteries. In spite of encouraging preliminary results, the use of this new type of vascular prosthesis still requires critical evaluation to avoid unpredictable failure due to uncritical surgical optimism (caution: Sparks disaster!). Further improvements may be expected from a better anchorage in the surrounding tissue (e.g., external velour), and from an increase of antithrombogenity of the inner surface.
Arteries↗
[Surgery in combined aorto-iliac and femoro-popliteal occlusive lesions (author's transl)].
In combined chronic occlusive lesions at the aorto-iliac and femoro-popliteal level the partial repair of the central vessel in combination with profundaplasty and lumbar sympathectomy ("triad procedure") represents a simpler and shorter procedure than the previously preferred total correction of both segments. In a retrospective study of 403 limbs (stage II-IV) the triad procedure shows a cumulative patency (life table analysis) of 77% vs. 39% in total repair. The amputation rate in triad procedure--for stage III/IV--was 8% vs. 36% and the frequency of reoperation 7% vs. 23% in total repair. Prerequisites for this type of repair are an optimal technique and a correct selection of patients presenting patient "receiving segment" of the popliteal artery and a sufficient run-off below the knee.
Aortic Diseases↗