Search PubMed⌕ Search

Biomedical subjects

J Vogt

Publications and source records attributed to J Vogt.

At least 127 records · Page 7Linked to original sources
PubMed1990

Ventilation parameters and arterial blood gases as a prediction of hypoplasia in congenital diaphragmatic hernia.

Attempts to predict the degree of pulmonary hypoplasia associated with congenital diaphragmatic hernia have been made by evaluating the ventilation parameters and the arterial blood gasses of these patients. A CO2 index as a predictor of outcome, which correlates the PaCO2 with the ventilation index, was recently proposed. However, in this study the postductal PaO2 was a better predictor of survival. And the so-called "honeymoon period" was a better indicator of the efficacy of extracorporeal membrane oxygenation (ECMO) than the CO2 index. Nineteen patients were evaluated; 11 were treated with ECMO, and eight were not considered suitable for ECMO.

Airway Resistance↗
PubMed1990

Fluoride and mineral redeposition in outermost layers of bovine enamel during surface softening.

Mineral and fluoride concentration changes in the outermost layers of bovine enamel (depth less than 1 micron) were measured after demineralization in unbuffered hydroxyethylcellulose gels of pH = 5.4 with an intrinsic fluoride concentration of about 0.02 ppm. A combination of two nuclear analytical techniques, Rutherford backscattering spectrometry (RBS) and proton-induced gamma ray emission spectrometry (PIGE) was applied to determine the Ca/P molar ratios and F depth profiles, respectively. When compared to deeper layers, a reduced loss of mineral content is observed for the depth range of about 0-0.1 micron corresponding well with a F concentration increase from about 500 to about 5,000 ppm in the same range. These findings are interpreted as a fluoride-induced partial remineralization of the superficial surface layer during an overall demineralization process.

Animals↗
PubMed1989

Fixed subaortic stenosis: an acquired secondary obstruction? A twenty-seven year experience with 168 patients.

168 patients with fixed subaortic stenosis (fixed SAS) were studied between 1959 and 1987. For assessment of the long term prognosis, the hemodynamic results of the catheterizations were compared with the angiograms. The obstructive lesions were divided into 4 basic types: 1) thin fibrous ridge subjacent to the valve, 2) funnel shaped, 3) irregular fibromuscular, 4) tunnel shaped. Operative reports were used in all and 2D-echocardiography in so far 67 patients to distinguish between pure fibrous and fibromuscular types. The average age at initial diagnosis was 7.8 years (5 weeks to 23 years). Only 4 of 168 patients had significant obstruction in early infancy. All 4 had Shone's complex. Progression of the disease was documented in 30 of 34 patients (80%) by serial catheterization; regrowth was noted in only 4. In 10 patients fixed SAS was not detected by the 1st catheterization but was present subsequently. 22 patients had additional dynamic obstruction, proved in 19 during the second decade of life. Among 132 operated patients, there were 11 early (8%) and 3 late (2%) deaths. Twenty underwent reoperation for residual obstruction. The mean postoperative gradient across the left ventricular (LV) outflow tract of 89 patients recatheterized after conventional operation was as follows: Type (1) 16 +/- 17, (2) 19 +/- 16, (3) 51 +/- 41, and type (4) 79 +/- 24 mmHg. Complete assessment confirmed that only 33% of the operations led to satisfactory hemodynamic results. Our data show that the pure fibrous forms have a better prognosis than the fibromuscular forms and are better differentiated by 2D-echocardiography than by angiography.(ABSTRACT TRUNCATED AT 250 WORDS)

Abnormalities, Multiple↗
PubMed1989

Transmission and control of methicillin-resistant Staphylococcus aureus in a skilled nursing facility.

Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly frequent in both acute care facilities (ACFs) and skilled nursing facilities (SNFs). Admissions to SNFs from ACFs with endemic MRSA are one likely source of infection in SNFs. The occurrence of MRSA in SNFs and the relative roles of ACFs and SNFs in MRSA transmission have not been well characterized. We conducted an epidemiologic investigation in an SNF reporting a high incidence of MRSA cases and found that the prevalence of MRSA exceeded that reported in acute care settings. Fifteen (9.1%) of the 164 residents were colonized or infected with MRSA. Risk factors for MRSA identified through a prevalence case-control study were nasogastric intubation (odds ratio = 5.5; 95% confidence interval = 1.2, 26.4), antibiotic therapy (OR = 3.9; CI = 1.2, 13.0), and hospitalization in an acute care facility within the previous six months (OR = 2.9; CI = 0.9, 9.7). During a three-month period, 6 of 100 new admissions were MRSA-positive; all positive patients were from ACFs. Five new cases also emerged from previously MRSA-negative residents. SNF residents are often discharged to ACFs. Transmission of MRSA within the SNF and the transfer of patients to ACFs increases the reservoir of potentially infective patients and the potential for MRSA infections in ACFs. Modest control measures, including targeted surveillance culturing and cohorting of colonized residents, may minimize MRSA transmission in the SNF and decrease the reservoir of MRSA in the community.

Aged↗
PubMed1989

Electrophysiologic, haemodynamic and antiarrhythmic effects of the new class Ic agent 1-(2'-biphenyloxy)-2-tert.-butylamino-propanol-2-hydrochloride.

The electrophysiological, antiarrhythmic and haemodynamic profile of the new compound GK 23-G (1-(2'-biphenyloxy)-2-tert.-butylamino-propanol-2-hydrochloride, proposed INN: bipranol) was examined using dogs models relevant to conditions in humans. In the first part of the study, dose-related effects of cumulatively increasing doses of GK 23-G (0.2-12.8 mg/kg) on intracardiac conduction, ventricular refractoriness and on haemodynamic parameters of the non-ischemic heart were determined in six anesthetized mongrel dogs. In the second part of the study, antiarrhythmic actions of bipranol on "delayed reperfusion ventricular arrhythmias" following release of coronary artery occlusion after 2 h of obstruction were investigated in another six dogs. The results show: GK 23-G causes a significant prolongation of HV-time, QRS-duration and ventricular refractory period at mid-range and high doses (greater than or equal to 3.2 mg/kg). QT-time does not change. Atrial refractory period is significantly lengthened at the maximum dose of 12.8 mg/kg. There are no significant changes in heart rate, systolic and diastolic aortic pressure and cardiac output. Up to 12.8 mg/kg, GK 23-G does not influence left ventricular contractility (dp/dtmax). In acute myocardial necrosis "delayed reperfusion arrhythmias" are almost completely abolished at a dose of 1.6 mg/kg + 50 micrograms/kg x min. Thus, because of its antiarrhythmic potency, further experimental and clinical testing of the new compound seems promising.

Animals↗
PubMed1989

Transposition of the great arteries with straddling tricuspid valve. Report of two rare cases with acquired subaortic stenosis after main pulmonary artery banding.

The clinical, hemodynamic, angiocardiographic, and postmortem findings of a previously unreported type of subaortic stenosis are presented in two patients who also had straddling tricuspid valve and transposition of the great arteries. The subaortic stenosis became apparent after banding of the main pulmonary artery and was due to hypertrophy of a probably abnormally positioned moderator band resulting in a double-chambered right ventricle. Fibrous tissue accumulation at the stenotic os infundibuli also contributed to the subaortic obstruction. Both patients had situs solitus of the atria. Patient 1 had ventricular inversion (L-loop ventricles) and atresia of the right-sided mitral valve. Patient 2 had normally positioned ventricles (D-loop) and two atrioventricular valves. The presence of a large left ventricle and a small right ventricle in the angiocardiogram led to the erroneous diagnosis of a single left ventricle with an infundibular outlet chamber in both patients. Consequently, the subaortic obstruction was thought preoperatively to be at the site of a restrictive bulboventricular foramen. Patient 1 died 36 hours after placement of a valved conduit from the left ventricle to the descending aorta. Patient 2 was operated on successfully and the surgical procedures performed are described.

Aortic Valve Stenosis↗
PubMed1988

Clinical use of extracorporeal membrane oxygenation in the treatment of persistent pulmonary hypertension following surgical repair of congenital diaphragmatic hernia.

The clinical use of extracorporeal membrane oxygenation (ECMO) in the treatment of persistent pulmonary hypertension following surgical repair of congenital diaphragmatic hernia is reported on 11 patients. The patients had a total of 13 treatments; two patients had two treatments. During the same period of clinical use, 122 patients were placed on ECMO for all causes. The indications, results, and complications of the use of ECMO for treatment following surgical repair of congenital diaphragmatic hernia are presented. The reversal of persistent pulmonary hypertension is demonstrated. All patients treated by ECMO for congenital diaphragmatic hernia have survived.

Extracorporeal Membrane Oxygenation↗
PubMed1988

[Lung sequestration as a cause of acute cardiac decompensation in a 3-week-old newborn infant].

A 3 week old neonate developed congestive heart failure after the operation of an omphalocele. The clinical aspect first suggested to us a persistent ductus arteriosus. Cardiac catheterisation then revealed a bronchopulmonary sequestration, a rare congenital malformation. Children usually become symptomatic with chronic respiratory tract infections, although there are also asymptomatic courses. Only a few cases are reported with congestive heart failure being the initial symptom. Many patients show additional malformations--so did our baby with an omphalocele and a mild peripheral pulmonary stenosis. Once the diagnosis is made, resection or lobectomy is the therapy of choice. In the preoperative diagnosis angiography is mandatory to demonstrate the abnormal vascular supply.

Angiocardiography↗
PubMed1988

[Late results following Rastelli corrective operations in transposition of great vessels].

From 1974 to 1985, 19 patients with transposition of the great arteries, ventricular septal defect and pulmonary valve stenosis or atresia underwent Rastelli correction. The mean age of the patients at operation was 9.7 years. Four patients died on the day of operation (early mortality: 21%). One patient died 7 years later due to dysrhythmias (overall mortality: 26%). Cardiac catheterization was performed on average 1.8 and 6.7 years after the operation. Gradients above 40 mm Hg were registered in 70% of the conduits, 6 years after the operation. Five patients underwent six reoperations for conduit stenosis. The actuarial survival rate was 75%; the event-free survival rate was only 20% after 12 years.

Adolescent↗
PubMed1988

[Unusually early onset of Kawasaki syndrome with coronary artery aneurysms].

Kawasaki disease is a multisystem illness that has been described throughout the world. It affects children with a peak frequency in the 6-month to 5-year group. Besides the typical clinical findings and specific laboratory changes during the initial phase of acute illness there are obligatory cardiovascular manifestations due to a generalized microvasculitis. Above all the coronary arteritis resulting in the formation of aneurysm may complicate a primarily good prognosis (causing death in 1-2% of the cases). The present case report describes a coronary artery involvement in a young 1 1/2-month-old infant with Kawasaki disease.

Cardiac Catheterization↗
PubMed1987

Memory enhancement in elderly humans: effects of glucose ingestion.

Recent findings demonstrate that, in rats, posttraining injections of glucose can enhance subsequent memory performance. The purpose of this study was to extend these findings to an elderly human population by testing the hypothesis that acute increases in peripheral blood glucose levels would enhance performance on memory tasks. Eleven subjects ranging in age from 58 to 76 years participated in the study. A within-subject, repeated-measures design was used in which each subject was tested under two different glycemic conditions: with fasting blood glucose levels and with increased blood glucose levels. Blood glucose was manipulated via consumption of beverages sweetened with either saccharin or glucose powder. After beverage consumption, subjects took four tests from the Wechsler Memory Scale. Comparisons of performance under the two glycemic conditions showed that scores were higher after the glucose beverage on narrative memory tests and the total Wechsler Scale. Nine of the eleven subjects had higher total Wechsler Scale scores. These results contribute to the growing evidence that glucose metabolism should be considered in the study of memory processes. The implications of such relationships for age-related memory deficits are discussed.

Aged↗
PubMed1987

[Anatomically corrected levo-malposition of the great arteries].

The term anatomically corrected malposition of the great arteries describes a very rare form of congenital heart disease. In contrast to corrected transposition of the great arteries (atrioventricular and ventriculo-arterial discordance) there is an atrioventricular and ventriculoarterial concordance. The abnormally located arteries arise above the anatomically correct ventricles, the pulmonary trunk originates above the morphologically right ventricle, the aorta arises above the morphologically left ventricle. The abnormal relation (malposition) between the great arteries results from interposition of bilateral abnormal conal myocardium with absence of aortic valve-mitral valve fibrous continuity. In this case report an anatomically corrected laevomalposition of the great arteries associated with dextrocardia and situs solitus, ventricular septal defect and bilateral abnormal conal myocardium with subpulmonary obstruction in a young infant is presented.

Aorta, Thoracic↗
PubMed1987

[Mucolipidosis type II (I-cell disease) with unusually severe heart involvement].

Mucolipidosis II (I-cell disease), an autosomal recessive inborn error of mucolipid metabolism with defective transport of lysosomal enzymes is described in a young infant. Besides the typical findings as a result of the "lysosomopathy", this case presented an unusual and distinct cardiac involvement: a cardiomyopathy with dilatation of the left ventricle and signs of an endocardfibroelastosis.

Cardiomyopathy, Dilated↗