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Biomedical subjects

J Vives

Publications and source records attributed to J Vives.

At least 109 records · Page 6Linked to original sources
PubMed1981

[Studies of complement, nephritic factor, and circulating immune complexes in chronic mesangiocapillary glomerulonephritis types I and II (author's transl)].

The complement components CH50, C3, C4, and C1q, factor B, nephritic factor (NF), and circulating immune complexes (CIC) have been studied in 22 patients with chronic mesangiocapillary glomerulonephritis (CMCGN). Of the 22 patients studied, eight had normal complement levels and 14 had hypocomplementemia with marked reductions of C3 and CH50. Of the latter 14 patients, nine disclosed an activation pattern that followed the alternate pathway, while in the other five the classical pathway was followed. The patients with hypocomplementemia following the alternate pathway and with positive NF activity (five cases) had a histologic pattern of type II CMCGN with dense deposits within the basal membrane, while those with hypocomplementemia following the classical pathway and negative NF activity disclosed a histologic pattern of type I CMCGN. The etiopathogenesis of these two types of glomerulonephritis remains to be elucidated. Although the presence of CIC is discussed and they are only rarely detected with the usual techniques, immune complexes have been implicated as possible responsible factors in these diseases. It has been demonstrated that the NF is an IgG with the characteristics of an autoantibody specific against the C3bB and C3bBb convertases of the alternate pathway, thus forming the trimolecular complex C3bBbNF. Because serum NF is frequently associated to type II CMCGN, it could be speculated that this trimolecular complex behaves as an immune complex, the convertase C3b beeing the antigen and the NF, the antibody, and that, under certain circumstances and because of its low molecular weight, it could cause nephritis by its deposit in the glomerular basal membrane.

Antigen-Antibody Complex↗
PubMed1981

Abortion may sensitize the mother to HLA antigens.

The incidence of cytotoxic antibodies in relation to histories of abortions was analyzed in sera from 474 nulliparous pregnant women. In patients with previous spontaneous abortions, there is a higher incidence of positive sera than in primigravidae. Furthermore, patients with two or more prior abortions show a greater incidence of cytotoxic activity in their sera than women who have had only one abortion.

Abortion, Spontaneous↗
PubMed1981

Further evidence against preeclampsia as an immune complex disease.

Sera from 25 preeclamptic women were examined for the presence of circulating immune complexes (CICs) by the radioisotopic C1q binding assay (C1q-BA), the polyethylene glycol precipitation-complement consumption (PEG-CC) test, and the microcomplement consumption test (MCT). Five abnormal values were found by the MCT; 4 became normal after delivery, as did the preeclamptic clinical signs. Normal values were obtained by the C1q-BA and the PEG-CC test in all preeclamptic patients. In addition, maternal HLA antibodies and complement levels were investigated. There was no correlation between lymphocytotoxic activity and CICs in sera from patients with preeclampsia. Complement levels were in the normal range in all cases. It is concluded that CICs do not play a significant role in the pathogenesis of preeclampsia.

Antigen-Antibody Complex↗
PubMed1981

Effects of HLA antibodies on pregnancy.

To investigate the effect of maternal HLA antibodies on the evolution of pregnancy, we tested sera from 187 pregnant women for the presence of lymphocytotoxic antibodies (anti-HLA-A, -B, and -C and anti-B lymphocytes or anti-HLA-DR). Patients were studied before 20 weeks, between 21 and 30 weeks, and between 31 and 40 weeks' gestation. No correlation was found between the presence of such antibodies and obstetric complications, fetal wastage, placental weight, or infant birth weight. Patients with anti-DR antibodies delivered more female than male infants by a 3:1 ratio.

Abortion, Spontaneous↗
PubMed1980

Histocompatibility-2 system in wild mice. X. Frequencies of H-2 and Ia antigens in wild mice from Europe and Africa.

In this study, data are presented on serologic H-2 typing of 320 wild mice collected in several parts of Europe and Egypt. The sample was typed for 39 class I (K, D) and 16 class II (Ia) antigens. The phenotype frequencies of class I and class II antigens showed high variability in their distribution among different areas, ranging from absence or presence in low frequency in one area to presence in about one-half of the mice in another area. The average phenotypic frequency of class I private antigens was 6.3%; at least 60% of class I alleles (blanks) could not be identified with the available reagents. The data suggest that there might be more than 100 alleles for each class I locus, H-2K and H-2D. The average phenotypic frequencies of Ia-1 private antigens was 10.8%. About 75% of Ia-1 alleles (blanks) could not be identified. The number of Ia-1 alleles was estimated to be in the range of 20 to 50.

Alleles↗
PubMed1980

Immunologic unresponsiveness after gastric administration of human gamma-globulin: antigen requirements and cellular parameters.

Gastric administration of human gamma-globulin (HGG) into adult A/J mice leads to the establishment of an antigen-specific unresponsive state to subsequent parenteral challenge with HGG. An unresponsive state is induced in both helper T and B lymphocyte populations. Unresponsiveness in helper T cells is of longer duration than in B cells, lasting at least 9 wk after intragastric intubation. Adoptive cell transfer of spleen cells from gastrically inoculated mice into healthy irradiated, syngeneic recipients revealed that the unresponsive state is stable upon cell transfer and that suppressor cells are present in the spleens of gastrically tolerized mice. The establishment of HGG-specific unresponsiveness is dependent upon both the dose and the form of the antigen adminstered. Soluble and deaggregated HGG are both more efficient than is heat-aggregated HGG in inducing unresponsiveness gastrically. The administered HGG is rapidly eliminated from the animal and only a small fraction reaches the circulation as immunoreactive protein. Although the cellular parameters of the systemic unresponsiveness induced by intragastric intubation with HGG appear similar to the parameters of parenterally induced unresponsiveness, the precise mechanisms by which gastric unresponsive states are established remain to be resolved.

Animals↗
PubMed1980

Kinetics of IgM and IgG responses in neonatally thymectomized Swiss mice under persistent immunization with sheep red blood cells.

The kinetics of IgM and IgG responses (direct and indirect PCF) in the Swiss mice, neonatally thymectomized, injected three times a week with 5 X 10(8) sheep erythrocytes at the age of two months, were exactly the same as the controls from the same litters. The thymectomized animals showed a statistically significant decrease in both responses (18.6 and 30.2%, respectively). The kinetics of the switch from IgM to IgG and of the latter response inhibition, is the same in both the control and the thymectomized animals.

Animals↗
PubMed1979

Primary biliary cirrhosis associated with HLA-DRw3.

Twenty-one unrelated Caucasian patients with Primary Biliary Cirrhosis were typed for HLA-A, B, C and HLA-DRw antigens. The antigens HLA-Al, HLA-B8 and HLA-DRw3 were found in increased frequency in relation to the control group. When the P values were corrected for the number of antigens tested only the increase of HLA-DRw3 remained significantly different from the control group (P crr. < 0.004). The antigen HLA-DRw3 was carried by 12 out of 21 patients (57.1%) in comparison to 11 out of 74 (14.8%) normal unrelated Caucasian subjects.

Autoimmune Diseases↗
PubMed1978

Prolymphocytic leukaemia of T-cell type: immunological, enzymatic and ultrastructural morphometric characteristics.

A case of prolymphocytic leukaemia with immunological characteristics of T-cell type is reported. Three noteworthy findings can be emphasized: the presence of C3 receptors on the T-prolymphocytes, the study of the acid-phosphatase isoenzymatic pattern, which showed an increased band 3 with absence of band 3b, and the morphometric ultrastructural investigation. Cytochemistry and ultrastructural morphometry may be useful for a more precise characterization of prolymphocytic leukaemia and help to distinguish it from other lymphoproliferative disorders.

Acid Phosphatase↗