[De novo colonic cancer].
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Biomedical subjects
Publications and source records attributed to J Vilotte.
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Candida infection of mild gastric ulcers was detected by gastric biopsy in 6 patients aged from 67 to 82 years. Filaments and spores were located in the connective tissue or submucosa in 3 cases and in the false membrane in the other 3. No predisposing cause was found in 5 patients. Chemical study of the gastric secretion was performed in all patients under maximal pentagastrin stimulation and showed normal acidity. The addition of amphotericin B to the anti-ulcerous treatment seems to have helped the ulcer to heal.
Systematic investigations testing for the presence of polyps and cancers of the large bowel were conducted in a population of 1,369 inpatients and outpatients, aged 45-70 years, in eight university departments of gastroenterology or abdominal surgery (Toulouse, Dijon, Paris, Marseille, and Strasbourg). Double-contrast barium enema and proctosigmoidoscopy examinations were carried out in all cases, whereas total coloscopy was performed only in the case of detected tumors. A questionnaire including 233 parameters (age, sex, family, and personal history and symptoms) was completed for each patient. A total of 414 lesions were detected in 252 patients, including 245 adenomatous or villous polyps, 8 transformed polyps, and 30 carcinomas; 3 of 4 lesions were located in the rectum or sigmoid. Cancer or adenomatous or villous polyps were found in 13% of the patients. The prevalence of these lesions in the population studied was increased in patients with rectorrhagia (19%) or with a personal history of surgery for colorectal cancer or polyp (23%). In the patients without rectorrhagia or a history of intestinal tumor, the incidence was 9.7%. It was significantly increased in males and patients more than 50 year old. The efficacy of proctosigmoidoscopy and double-contrast barium enema was compared in 909 patients. Sensitivity and specificity were, respectively, 35% and 99% for endoscopy, 96% and 94% for radiology.
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