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Biomedical subjects

J Vilkki

Publications and source records attributed to J Vilkki.

66 records · Page 4Linked to original sources

Is chronic brain damage in boxing a hazard of the past?

Of fourteen boxers with a mean age of 31 years who had been Finnish, Scandinavian, or European champions, only one showed deficits in neurological status and he and one other had had episodes of inappropriate behaviour which were attributed to boxing. However, computed tomography revealed pathological findings attributable to brain injury in four of six professional and one of eight amateur boxers. Two of the professionals and four of the amateurs had electroencephalographic abnormalities which may have been caused by brain injury. Twelve of the boxers had psychological test results which suggested brain injury, although only two professionals had definite deviation from normal. The results indicate that modern medical control of boxing cannot prevent chronic brain injuries but may create a dangerous illusion of safety. The only way to prevent brain injuries is to disqualify blows to the head.

Adolescent↗

Intracranial arterial aneurysms in children and adolescents.

This is a report on 32 patients with subarachnoid haemorrhage caused by rupture of an intracranial arterial aneurysm in the 0-19 age group. Sixteen of the aneurysms were situated in the bifurcation of the internal carotid artery, 8 in the anterior communicating artery, 4 in the posterior communicating artery, two in PICA, one in the middle cerebral artery, and one in the pericallosal artery. Direct intracranial clipping of the neck of the aneurysm was carried out in 26 cases, proximal clipping in three, wrapping in two, and common carotid ligation in one case. There was one death from surgery. The surgical mortality was thus 3.1%. In 80% of cases the result was good, i.e., the patient had no neurological deficit and was able to work or continue at normal school. The psychological tests indicated some cognitive deficits in aneurysm patients as compared to the control patients. The common feature of these deficits seemed to be an impairment of active retrieval and searching of memory, while common cognitive skills were usually preserved. Four of the five patients who were disabled had obvious deficits in their performances. In the other patients these deficits did not affect their capacity for work or studies, and they were usually unaware of them. Children seem to tolerate surgery better than adults. Comatose or drowsy patients should not be operated on. The operative method of choice is direct intracranial clipping of the neck of the aneurysm.

Adolescent↗

Observations on physiological and psychological functions of the ventral oral internal nucleus of the human thalamus.

Eight patients underwent VOI thalamotomy for spasmodic torticollis or choreoathetosis. The clinical results were disappointing: at follow-up examination 8 months postoperatively, on average, none of the seven patients with torticollis regarded the effect as good. In two there was some long-lasting improvement, but in five the results was nil. One patient with choreoathetosis did not benefit from surgery. Side-effects were frequent but not serious; they included excessive sleepiness, drowsiness, weight increase, deterioration of memory and loss of general activity. Electrical stimulation of the VOI nucleus caused subjective sensations in the neck and shoulder muscles without movements of the head, and autonomic or emotional reactions. An evoked scalp response was recorded in contralateral frontal area 8. As shown by psychological tests, in visuospatial performances there is a preoperative defect, which seems to be specific to spasmodic torticollis. After left VOI thalamotomy both receptive and expressive verbal efficiency were impaired. Visual perception and memory were almost unaffected by VOI thalamotomy.

Adult↗

Neuropsychology of mental programming: an approach for the evaluation of frontal lobe dysfunction.

Patients with frontal lobe lesions tend to have poor psychosocial recovery, yet they may perform well on common cognitive tests. Their habitual cognitive skills seem to be preserved, whereas the purposeful utilization of skills in novel situations is impaired. This paper reviews neuropsychological disorders and models of mental programming. An approach for the evaluation of programming deficits is presented and some implications of the conception are considered. Programming is defined as the subjective optimization of subgoals for the achievement of the overall goal with available skills. It is posited that programming is critically dependent on prefrontal functions. Measures of programming were found to be sensitive to the effects of frontal lesions and closed-head injuries, as well as, to predict subsequent social recovery. Programming can be seen as an intermediate process between performance and motivation, the subjective optimization of subgoals integrates motivation and skills (operational resources) to purposeful activity.

Journal Article↗

Genetic diversity and population structure of 20 North European cattle breeds.

Blood samples were collected from 743 animals from 15 indigenous, 2 old imported, and 3 commercial North European cattle breeds. The samples were analyzed for 11 erythrocyte antigen systems, 8 proteins, and 10 microsatellites, and used to assess inter- and intrabreed genetic variation and genetic population structures. The microsatellites BoLA-DRBP1 and CSSM66 were nonneutral markers according to the Ewens-Watterson test, suggesting some kind of selection imposed on these loci. North European cattle breeds displayed generally similar levels of multilocus heterozygosity and allelic diversity. However, allelic diversity has been reduced in several breeds, which was explained by limited effective population sizes over the course of man-directed breed development and demographic bottlenecks of indigenous breeds. A tree showing genetic relationships between breeds was constructed from a matrix of random drift-based genetic distance estimates. The breeds were classified on the basis of the tree topology into four major breed groups, defined as Northern indigenous breeds, Southern breeds, Ayrshire and Friesian breeds, and Jersey. Grouping of Nordic breeds was supported by documented breed history and geographical divisions of native breeding regions of indigenous cattle. Divergence estimates between Icelandic cattle and indigenous breeds suggested a separation time of more than 1,000 years between Icelandic cattle and Norwegian native breeds, a finding consistent with historical evidence.

Alleles↗