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J Vermeulen

Publications and source records attributed to J Vermeulen.

49 records · Page 3Linked to original sources
PubMed1989

Spontaneous speech in aphasia: a correlational study.

Seventeen spontaneous speech measures and scores on a naming test, employed to characterize the expressive performance of 121 aphasics, were subjected to a factor analysis. Five factors were obtained: (1) Syntactic ability, (2) Phonological paraphasia, (3) Neologistic paraphasia, (4) Articulatory impairment, and (5) Vocabulary. Relationships of the factors to naming error types were examined in order to elucidate the nature of some of the factors. Also, the relationships of the expressive factors to auditory comprehension tests were explored, such an exploration being relevant to the issue of the overlap between expressive and receptive functions.

Anomia↗
PubMed1988

[Fatty cerebral embolism after lymphography].

A 25 year-old man with Hodgkin's disease, presented a confusional state with choreatic movements, 1 hour after a lymphography. CT showed high density in the heads of both caudate nuclei, and in the cortex. The patient's state improved and he entirely recovered within 2 weeks, while CT returned to normal. No right-to-left shunt was demonstrated. The mechanisms of this infrequent complication of lymphography are discussed: exceeding filtration capacity of lung because of a too rapid administration of contrast or severe lung embolism? intracardiac right-to-left shunts? microscopic arteriovenous shunts in the lung? bad venous cerebral drainage consecutive to a vena cava superior syndrome?

Adult↗
PubMed1986

Progesterone in saliva: pitfalls and consequent implications for accuracy of the determination.

The concentration of steroid hormones in saliva is believed to reflect the concentration of free hormone in blood. Because the assay for progesterone in saliva has not been rigorously validated, we investigated some of the analytical variables involved. Saliva samples were divided into two portions. One was centrifuged and the supernate used for extraction; the other was homogenized by sonication and used as such for extraction. Progesterone concentrations in homogenized whole saliva were double or triple those in supernates. By equilibrium dialysis we established that 85% of progesterone was in the free form in supernates but only 60 to 70% in homogenized whole saliva, depending upon the phase of the cycle of the subjects. Salivary flow was stimulated by crystals of citric acid; unstimulated and stimulated saliva samples were obtained from the same person. Progesterone concentrations were significantly (p less than 0.02) higher in stimulated samples than in unstimulated ones, particularly in samples collected during the luteal phase.

Body Fluids↗
PubMed1982

Auditory language comprehension in aphasia: a factor-analytic study.

A battery of nine auditory comprehension test, taken by seventy aphasics, was subjected to a factor analysis. Two factors, interpretable respectively as a lexical semantic and a syntactic comprehension factor, were obtained. Comprehension described in terms of these factors was found to be related to criterion variables of importance, namely the Token Test and a rating of comprehension in daily life. Broca's aphasics were found to be more impaired in syntactic than in lexical semantic comprehension; Wernicke patients tended to have low scores on both factors. The results of this study support the view of independent lexically based and syntactic processing in auditory comprehension which can be differentially disrupted by brain damage.

Adult↗
PubMedDate not supplied

Language activation distributions revealed by fMRI in post-operative epilepsy patients: differences between left- and right-sided resections.

OBJECTIVE: To reveal differences of cerebral activation related to language functions in post-operative temporal lobe epilepsy (TLE) patients. METHODS: Right (RTL) and left temporal lobe (LTL) resected patients, and healthy controls were studied using functional magnetic resonance imaging (fMRI). Only patients with complete left-hemispheric language dominance according to the intracarotid amytal procedure (IAP) were included. Language-related activations were evoked by performing word generation and text reading language tasks. Activation lateralization and temporo-frontal distribution effects were analysed. RESULTS: For word generation, only LTL patients showed reduced left lateralized activation compared to controls, due to a decrease in activation in the left prefrontal cortex and an increase in the right prefrontal cortex. For reading, the left-hemispheric lateralization in RTL patients increased because of enhanced activity in the left prefrontal cortex, whereas for LTL patients the activation became bilaterally distributed over the temporal lobes. Lateralization results between pre-operative IAP and post-operative fMRI were highly discordant. Significant temporo-frontal distribution changes manifested from the reading but not from the word generation task. CONCLUSION: The cerebral language representation in post-operative LTL epilepsy patients is more bi-hemispherically lateralized than in controls and RTL patients. Post-operative temporo-frontal and interhemispheric redistribution effects, involving contralateral homologous brain areas, are suggested to contribute to the cerebral reorganisation of language function.

Adult↗
PubMedDate not supplied

Gamma-vinyl GABA (vigabatrin) and mood disturbances.

We explored factors that may predispose patients to adverse mood effects during treatment with vigabatrin (gamma-vinyl GABA; VGB): mood disorders before VGB treatment, type of epilepsy, seizure type and seizure frequency, type and number of comedication, and VGB dose. The clinical relevance of such a study is that it may help identify circumstances in which VGB should be administered with caution. Seventy-three patients (40 males, 33 females), all with refractory epilepsies, who received VGB as add-on therapy, were assessed by the Amsterdamse Stemmingslyst (ASL), a mood-rating scale, before the start of treatment, and demographic and clinical data were recorded. The patients were followed for 6 months after the start of VGB treatment. Treatment with VGB had to be discontinued in 38 patients (52% of the total sample). Mood problems were the main reason for discontinuation in 9 (12.3% of the total sample). In 6 other patients, mood problems were mentioned as the reason for discontinuing treatment, in combination with lack of drug efficacy. Development of adverse mood effects could not be predicted by a specific mood profile on the ASL. Before treatment, the "mood problems discontinuation group" did not show extreme scores for any assessed areas of mood and no significant differences from other patients were noted on the mood scales. Neither did clinical or demographic data show statistically confirmed specific characteristics for the mood problems discontinuation group, though the patients tended to use more antiepileptic drugs (AEDs) as cotherapy, to have a slightly lower daily dose of VGB, to be slightly older, and were mostly female.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Effects of antiepileptics drugs on cognition].

The cognitive effects of the most commonly used antiepileptic drugs (AEDs) are reviewed, discussing both the absolute effects (the effects compared to no treatment) and the relative effects (the comparison of one AED with an other). The cognitive profile per AED is given, based on a literature database, consisting of 1,357 articles in peer review journals. Available information on the newer AEDs is discussed as an addendum.

Anticonvulsants↗