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Biomedical subjects

J Vardi

Publications and source records attributed to J Vardi.

44 records · Page 3Linked to original sources
PubMed1975

On the synchronizing effect of amantadine-1-hydrochlorid (Symmetrel) on pathological EEG-activity.

The pathological EEG of a 60 years old lady who suffered from an organic mental syndrome with parkinsonian features, showed diffuse, slow asynchroneous activity. Administration of Symmetrel repeatedly and consistently caused a normalization of the EEG, while its discontinuation immediately led to the reappearance of the original desynchronized pattern. These EEG changes were not accompanied by any modifications in the patients' clinical condition. This discrepancy between the antiparkinsonian and the synchronizing effect of Symmetrel upon the EEG can be explained by a specific activity on the reticulo-thalamo-cortical pathways in addition to that upon the nigro-striatal tracts.

Amantadine↗
PubMedDate not supplied

R.H.I.S.A. -- cysternography study in sporadic choreo-athetotic syndrome accompanied with dementia (sporadic Huntington disease).

Seven patients who suffered from choreo-athetotic movements, accompanied by slowly progressive mental and affective decline over several years, without hereditary background, were admitted for clinical and psychodiagnostic tests. Laboratory examinations and anamnestic data were negative, and therefore a presumed diagnosis of sporadic Huntington disease was made. In order to verify the diagnosis, we had done P.E.G. -- Contrast study, and R.H.I.S.A. -- Cysternography. The P.E.G. -- Contrast demonstrated an enlargement of the sub-arachnoidal space and a symmetrical enlargement of the ventricular System, that may represent cortical and sub-cortical atrophy. The R.H.I.S.A. -- Cysternography Study showed in our patients the characteristics of the Mixed type Pattern: combined ventricular penetration with delayed para-sagittal absorption. Considering the results of the R.H.I.S.A. Studies, that correspond to the P.E.G. -- Contrast Studies, and its invulnerability towards patients, we presume that R.H.I.S.A. may be preferred as a diagnostic tool in Sporadic Huntington Disease.

Aged↗
PubMedDate not supplied

[Effect of bromocriptine on secretion of the enzyme dopamine-B-hydroxylase (DBH) in patients with Parkinson's disease].

The activity of DBH enzyme was measured in plasma of 7 non treated patients suffering from Parkinson's disease; a 10 mg dose of Bromocryptine was administered per os to these patients. Attained results were compared to the enzyme activity in a group of control of 7 healthy individuals. It was pointed out that in patients suffering from Parkinson's disease the decrease of DBH level in plasma after the administration of Bromocryptine was of 32.6% +/- SE 4.4% while in the group of control the decrease was only of 15% +/- SE 4.9%. This decrease in the plasmatic level of the enzyme after the administration of Bromocryptine should be due to the marked antagonistic activity of Bromocryptine on pre-synaptic dopaminergic receptors. This should mean that peripheric pre-synaptic dopaminergic receptors are involved in the physiopathology of Parkinson's disease.

Bromocriptine↗