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J Vanden Berghe

Publications and source records attributed to J Vanden Berghe.

5 recordsLinked to original sources
PubMed2001

Speech recognition in noise for cochlear implantees with a two-microphone monaural adaptive noise reduction system.

OBJECTIVE: In this study the performance of a noise reduction strategy applied to cochlear implants is evaluated. The noise reduction strategy is based on a 2-channel adaptive filtering strategy using two microphones in a single behind-the-ear hearing aid. DESIGN: Four adult LAURA cochlear implant users (Peeters et al., 1993) took part in the experiments. The tests included identification of monosyllabic CVC (consonant-vowel-consonant) words and measurements of the speech reception threshold (SRT) of lists of numbers, in background noise presented at 90 degrees relative to the 0 degrees frontal direction of the speech. Percent correct phoneme scores for the CVC words at signal to noise ratios (SNRs) of -5, 0, and +5 dB in steady speech-weighted noise at 60 dB SPL and SRTs for numbers in speech-weighted steady and nonsteady ICRA noise were both obtained in conditions with and without the noise reduction pre-processing. Physical SNR improvements of the noise reduction system are evaluated as well, as a function of the direction of the noise source. RESULTS: Highly significant improvements in speech understanding, corresponding on average to an SNR improvement of about 10 dB, were observed with this 2-channel adaptive filtering noise reduction strategy using both types of speech-noise test materials. These perceptual evaluations agree with physical evaluations and simulations of this noise reduction strategy. Taken together, these data demonstrate that cochlear implantees may increase their speech intelligibility in noisy environments with the use of multimicrophone noise reduction systems.

Adult↗
PubMed2000

Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH.

Tumor necrosis factor (TNF) induces hepatitis when injected in human beings or in rodents. The molecular mechanism by which TNF induces hepatic distress remains largely unknown, although induction of apoptosis of hepatocytes appears to be an essential step. In order to increase the therapeutic value of TNF, we have studied the protective activity of several molecules and found that four chemically totally different substances confer significant protection in the model of TNF-induced lethal hepatitis in mice sensitized with D-(+)-galactosamine (GalN), but not in mice sensitized with actinomycin-D (ActD) or against anti-Fas-induced lethal hepatitis. Verapamil, a calcium-channel blocker, tannic acid, picotamide, a thromboxane A(2) receptor antagonist, and K76COOH, an inhibitor, amongst others, of complement, protected significantly against induction of lethality, release of the liver-specific enzyme alanine aminotransferase (ALT) and induction of apoptosis in the liver after TNF/GalN, except for K76COOH, which paradoxically increased ALT values after challenge, and which also protected against TNF/GalN in complement-deficient mice. The data suggest that activation of platelets and neutrophils, as well as induction of inflammation occur in the TNF/GalN model, but not in the TNF/ActD or anti-Fas models, in which direct induction of apoptosis of hepatocytes may be more relevant. The protective activity of the drugs may lead to an increase in therapeutic value of TNF.

Alanine Transaminase↗
PubMed1998

An adaptive noise canceller for hearing aids using two nearby microphones.

An adaptive noise cancellation scheme based on two-stage adaptive filtering as proposed by Van Compernolle [Proceedings of the IEEE International Conference on Acoustics, Speech and Signal Processing (IEEE, New York, 1990)] was tested for two identical directional microphones mounted in an endfire configuration within a single behind-the-ear (BTE) hearing aid. Speech intelligibility tests were carried out with two normal hearing subjects and three hearing aid users with moderate hearing losses, in a realistic test environment using open set words and sentences. A significant improvement, on average more than 5 dB, of speech reception threshold (SRT) in background noise was obtained.

Amplifiers, Electronic↗