Xenograft adaptation is dependent on the presence of antispecies antibody, not prolonged residence in the recipient.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
J Van den Bogaerde
Publications and source records attributed to J Van den Bogaerde.
Prolonged survival of skin grafts following treatment with an antibody to a putative cell triggering molecule, QCA-1.
The QCA-1 molecule (quiescent cell antigen-1) appears to be involved in the differentiation events undergone by T cell following occupancy of the antigen receptor. Here we show that modulation of the QCA-1 antigen from the surface of the cell normally follows activation, and that treatment of animals with the antibodies against the QCA-1 molecule inhibits the normal response to an allograft without appearing to alter the number of peripheral T cells or the expression by these cells of the alpha/beta T cell antigen receptor.
Animals↗
Renal function in burns.
The present study evaluates the evolution of renal function parameters and serum electrolytes in 34 severely burned patients. The population was arbitrarily subdivided in a group with normal renal function (n = 24) and a group with acute renal failure (n = 10), defined by the fact that serum creatinine rose above 2.5 mg/dl at least once. The patient group with normal renal function was characterized by a normal to high creatinine clearance, reaching a consistent peak at day 2 of follow-up. Serum sodium and fractional sodium excretion were low. Further disturbances were a low serum protein, an early hypocalcemia and hypophosphatemia, and a discrete metabolic alkalosis. The patients developing acute renal failure maintained a low fractional sodium excretion. They were in general of older age and had more severe burns than the patients with normal renal function. The survival rate in the patients with acute renal failure was 30%, compared to 75% in the patients, who maintained normal renal function.
Acute Kidney Injury↗