Search PubMed⌕ Search

Biomedical subjects

J Valenta

Publications and source records attributed to J Valenta.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Role of pulse spray thrombolysis in acute ischemia of the extremities--comparison of results with the low dose technique of local thrombolysis, embolectomy and thrombectomy].

BACKGROUND: The reported mortality of patients suffering from acute limb ischemia is in the range of 10% to 30%, as is the incidence of amputation in the survivors. MAIN PURPOSE: The evaluation of the pulse spray thrombolysis (PST) role in the treatment of acute extremity ischemia originating from thrombosis or embolism of native artery or bypass graft. The comparison of PST with low dose technique thrombolysis (LD), thrombectomy (TE) and embolectomy (EE). METHODS: Ninety nine consecutive patients were evaluated during a two year interval (1994-1996). PST, resp. LD, TE and EE were the method of choice in 22, resp. 11, 35 and 31 patients of average age 58.3 +/- 13.7; resp. 60.0 +/- 8.9; 74.2 +/- 11.7; 76.9 +/- 9.3 years. The native artery was occluded in 15 (68.2%), resp. 8 (72.7%), 31 (88.6%) and 30 (96.8%) patients with PST, resp. LD, TE and EE treatment. The vascular reconstruction was occluded in the rest of the cases. The lower limb extremity arteries were occluded in 20 (90.9%) of patients indicated for PST, 10 (90.9%) for LD, 33 (94.3%) for TE and 26 (83.9%) for EE. The contraindication for local fibrinolysis was severely ischemic limb in which viability was imminently threatened. RESULTS: PST was successful in 19 (86.4%), LD in seven (63.4%), TE in 13 (37.1) and EE in 27 (87.1%) patients. The failure of procedure required amputation in one patient (4.5%) with PST, one (9.1%) with LD, nine (25.7%) with TE-p < 0.001 and two (6.5%) with EE. The mortality was 4.5% (one patient), resp. 0%, 28.6% (10 patients)-p < 0.001 and 3.2% (one patient) in PST, resp. LD, TE and EE. The long term results were better if the successful local fibrinolysis was combined with percutaneous transluminal angioplasty (PTA), stent implantation or small vascular reconstruction. CONCLUSION: PST is the method of choice in the treatment of thrombotic or embolic occlusion of native artery or bypass graft in condition of good limb viability where there is no danger of time delay. EE is indicated in limb embolism where the viability of extremity is threatened. Thrombectomy alone has no place in the treatment of artery or bypass graft thrombosis.

Embolectomy↗
PubMed1996

[Use of endogenous proteins in the early diagnosis of dysfunction in transplanted kidneys].

The early diagnosis of renal allograft dysfunction in the immediate posttransplantation period is very important. The prospective study was undertaken in 60 patients after kidney transplantation. The significance of blood and urine levels of glomerular and tubular proteins was studied for early diagnosis of allograft dysfunction. The authors evaluate some glomerular (CRP, transferrin, immunoglobulins) and tubular (alfa 1 microglobulin and beta 2 microglobulin) proteins for differential diagnosis of acute tubular necrosis and acute rejection of transplanted kidney.

Adult↗
PubMed1994

Modelling tissue behaviour based on hyperelasticity theory.

The tissues are during their physiological function, e.g., in the course of growth, adolescence, and aging, subjected to a cyclic mechanical loading and to large displacements and rotations as well. A tissue free of all external tractions is in a state that minimizes its internal power. In the course of aging of the tissues, for instance in the wall of the aorta, the vein, and also in the myocardium or heart valves, the decrease of the water content and increase of the collagen content occurs; while in compact and trabecular bone the contents of both mineral substances and collagen, undergo reduction. In accordance with it, the strain energy function and the constitutive equations of living tissue based on the hyperelasticity theory using rotationless strain were studied. On the base of the proposed eigenvalue decomposition of the rotationless strain tensor and hyperelasticity the strain energy function was formulated as depending on biological time of tissue. The quantity of strain energy function per unit of the biological time, which essentially characterizes the velocity of change of mechanical response of tissue in the course of its aging, was also defined. The coefficient of tissue aging is the further diagnostic parameter, which is independent of the rotationless strain tensor and expresses the relative change of mechanical response of tissue during the biological time. The corresponding constitutive equation of tissue depending on the biological time is also determined. On the base of the regression analysis the theoretical stress-strain curves for myocardium and blood vessels were determined. The numerical results reveal that the coefficient of aging progressively increases in hardening tissues (coronary artery, vena cava inferior) whereas at the softening tissues it has a relatively slow increase at the dependence on tissue aging.

Adolescent↗
PubMed1994

[Continuous ambulatory peritoneal dialysis--an effective method of treatment in chronic renal failure].

The authors evaluate the results of treatment of continuous ambulatory peritoneal dialysis (CAPD) in seven patient with chronic renal failure during a 12-month period. The baseline examination was made one month before CAPD was started, one day before insertion of a Tenckhoff catheter and then after 1, 3, 6 and 12 months of treatment. The highest assessed mean serum urea concentrations during treatment were 19.8 +/- 2.3 mmol/l (arithmetic mean +/- SE of the mean), creatinine 815.1 +/- 43.1 mmol/l. The haematocrit improved significantly due to CAPD. From the mean value of 22.5 +/- 1.7% recorded one month before treatment it increased to 32.8 +/- 2.5% after 12 months of therapy. In five patients CAPD made it possible to discontinue and in two to reduce antihypertensive medication. During the investigation period the authors did not detect a drop of total protein and albumin in serum. Serum cholesterol increased significantly during treatment. Peritonitis was recorded four times during the total period of 70 months of treatment, i.e. on average one episode during 17.5 months of treatment. Based on their results the authors conclude that CAPD is at present one of the very effective methods of treatment of chronic renal failure. The incidence of peritonitis was already during the first year when treatment was initiated comparable with the results in departments where it is commonly used and after further experience it declined to one episode per 38.8 months of treatment. The method deserves wider application than hitherto.

Adult↗
PubMed1992

[Arterial injuries of the upper extremities].

At the Department of Surgery in Pilsen in 1982-1991 a total of 26 patients with upper extremity vascular injuries was treated. Brachial artery was injured most commonly (50%). The direct trauma was responsible for 88.5% injuries, indirect injury was recorded in 11.5% cases only. The incidence of concomitant injuries of the vein, nerve or bone was 73.1%. Approximately one third of arterial injuries was caused by criminal offences. The vascular reconstruction was performed in all 26 patients. The overall patency rate was 84.6%, the amputation rate was 3.8%. One patient with polytrauma died of sepsis (3.8%). The authors give a comprehensive review of the causes, diagnosis and treatment of vascular injuries of the upper extremities.

Adolescent↗
PubMed1992

[Extra-anatomic bypasses in reconstructive vascular surgery in the lower extremities].

Extra-anatomic Bypass was used in 36 patients for limb salvage at the Department of Surgery, University Hospital in Pilsen in a period of almost eleven years (1th January 1981-1th November 1991) constituting 8.2% of all vascular reconstructions. Amputation rate was 22.2% and mortality rate 8.3% (without direct connection with reconstruction). Extra-anatomic reconstruction was used in such cases only where the anatomic bypass was excluded for general or local causes.

Adult↗
PubMed1992

[Drug therapy in vascular occlusions of the lower extremities].

The authors report their three-year experience with application of thrombolytic treatment in 31 patients with vascular occlusions of the lower extremities. They were successful in two thirds of the patients. The authors analyze the advantages and shortcomings of systemic or selective administration of antithrombotic therapy. Concurrent administration of hyperbaric oxygen is a rational therapy.

Adult↗
PubMed1991

[Incidence of aneurysms of the abdominal aorta in the Czechoslovak population and possibilities of its detection].

A significant increase not only in the number of operations for AAA but also in the incidence of autopsy findings of AAA from 1.5 per cent to 4.5 per cent has been observed during the last 20 years. Ultrasound screening of the abdominal aorta in patients examined for other reasons revealed asymptomatic dilatation of the infrarenal aorta to more than 4 cm in 3.8 per cent of men older than 60 years. AAA should be actively searched for at every physical and ultrasound examination of the abdomen in men over 60 years of age.

Aged↗
PubMed1991

[Venomous snake bites].

Although venomous snakebites are not a serious world wide problem from the epidemiological point of view and are rare under our conditions, it is frequently a very serious and life threatening matter. The patient's prognosis depends among others also on early adequate and comprehensive therapeutic measures. The authors give a list of poisonous snakes and types of toxins and their action on man. Next they describe principles of first aid, specific and non-specific therapy of snakebites and complications resulting from intoxication. The article is supplemented by a special chapter on Viper berus and several clinical cases of snakebites by tropical poisonous snakes.

Humans↗
PubMed1990

[Aneurysms of the peripheral arteries].

The authors discuss the problem of the right peripheral arterial aneurysm. In 1985-1989, five patients with peripheral arterial aneurysm were operated on at the surgical department, teaching hospital. Plzen. The paper gives an account of each case pointing to the specific features of this particular part of vascular surgery. Further, the authors describe the etiology, diagnostics and treatment of the disease.

Aged↗
PubMed1990

[Fibrinolytic therapy of acute arterial occlusions in the lower extremities].

The authors submit their initial experience with fibrinolytic treatment of acute arterial occlusions. In a group of 14 patients streptokinase and urokinase was administered 12 times as general treatment and twice locally. Treatment was successful in seven patients, no change in the local finding was recorded in two patients, in another two patients despite treatment progression of the ischaemia occurred. Two patients died in causal relation with treatment, one patient died for other reasons. Based on their own experience and that of authors abroad the authors emphasize the necessity of strict indication for fibrinolytic treatment, they prefer local to general administration, with regard to the number of complications. In the authors' opinion fibrinolysis holds a justified position in the treatment of acute arterial occlusions as a supplementary method of surgical treatment.

Acute Disease↗
PubMed1990

[Surgical and infectious complications after kidney transplantation].

Analysis of 100 consecutive cadaverous renal transplants revealed significantly better long-term graft function and patient survival rates and lower incidence of surgical postoperative complications in the second 50 transplants in comparison with the first 50 transplants. The incidence of infectious complications declined with the decrease in the corticosteroids dosage. Severe mycotic infections were prevented by prophylactic administration of antimycotic drugs and by shortening the period of prophylactic antibiotic treatment to 24 hours.

Adolescent↗
PubMed1989

[Malignant hyperthermia associated with epidural conduction anesthesia].

In a case-history the authors describe the development of malignant hyperthermia in conjunction with epidural anaesthesia. The development of this syndrome was arrested by early therapy with dantrolene and comprehensive treatment. A brief account of the character of this syndrome and its treatment is given.

Anesthesia, Epidural↗
PubMed1989

[Initial experience with autologous thrombocytes labeled with 111indium-oxine].

The authors elaborated their own modification of the separation and labelling of autologous thrombocytes by means of 111indium-oxine which can be implemented in Czechoslovak departments of nuclear medicine with standard equipment. A total of 123 separations and labellings were made and 85 administrations to patients. The effectiveness of labelling by the described method was 79.5 +/- 6.9%, the separation yield of thrombocytes with regard to complete blood 44.3 +/- 13.8%. The aggregating capacity of the labelled platelets assessed in vitro after ADP stimulation (adenosine diphosphate) was 39.5 +/- 10.1% difference in optic density of platelet rich and platelet poor plasma which is evidence of the preserved viability of thrombocytes. "Recovery" during the 120th minute after administration of normal suspensions was 62.2 +/- 17.9%, the survival time of labelled thrombocytes 8.2 +/- 0.74 days. In patients with idiopathic thrombocytopenic purpura the "recovery" was 49.4 +/- 18%, the survival period 2.9 +/- 1.8 days. In patients after transplantation of the kidney complicated by acute rejection there was an increased accumulation of labelled platelets in the area of the kidney (count rate index 2.32 +/- 0.45). In normally functioning transplanted kidneys the count rate index was 1.42 +/- 0.06. On their own material the authors demonstrate other possibilities of clinical application of scintigraphy by means of labelled autologous platelets (a method hitherto not described in the Ccezhoslovak literature) for the detection of intracardial and arterial thrombosis.

Blood Platelets↗
PubMed1989

[Inflammatory acute abdomen as an early postoperative complication].

The authors give an account of twelve cases of inflammatory acute abdominal attacks which complicated the course after abdominal operations. Although rare complications are involved, they are very serious and to a certain extent instructive. In the conclusion the authors summarize some diagnostic, therapeutic and assessment rules for these uncommon situations.

Abdomen↗
PubMed1989

[Secondary access routes for hemodialysis].

During the period of 1970-1985 375 arteriovenous fistulae were constructed in 248 dialyzed patients. The number of fistulae needed for long-term dialysis was significantly higher in women. Five-year cumulative patency rates were significantly better in the first fistulae than in the second, third or following fistulae. The best long-term patency rates were achieved in radiocephalic fistulae. Of all secondary vascular access procedures saphenous vein grafts proved to be the most reliable.

Adolescent↗
PubMed1989

[Symptomatic aneurysms of the abdominal aorta].

In the years 1981-1985 21 patients were operated upon for symptomatic abdominal aortic aneurysms. Atypical symptoms such as acute pancreatitis, weight loss, blood in the stool or urine, incorrect interpretation of abdominal pain and physical examination findings caused erroneous initial diagnosis and delay in referring the patient to surgical treatment in nine cases. Long history prior to admission was noted even in patients with ruptured aneurysms; mortality in these patients was high, 66%. Best results were achieved with aneurysm resection; indirect aneurysm occlusion in combination with axillofemoral bypass attempted in two patients was not successful.

Aged↗