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Biomedical subjects

J Vacek

Publications and source records attributed to J Vacek.

At least 37 records · Page 2Linked to original sources
PubMed1983

Tumour rejection in immunized guinea-pigs.

The morphological aspect of the antineoplastic defence mechanism was studied in Sewall-Wright strain 13 guinea pigs using isogeneic line 2 hepatoma cells. When these tumour cells were injected i.p. into isogeneic hosts, they grew rapidly and always killed their hosts within 8 weeks. An intradermal injection of line 2 hepatoma cells in strain 13 guinea-pigs 3 weeks before i.p. challenge with the same tumour cells protected such pre-immunized animals. While the intradermal inoculum failed to grow, it conferred sufficient immunity to enable the host to reject the tumour after a short period of growth. This phenomenon showed immunological specificity since intradermal injection of allogeneic hepatoma cells did not offer this protection. By using sequential histological analysis in these preimmunized animals, we were able to identify 2 sets of cells migrating into and around tumour modules in relation to tumour cell death. Firstly, small numbers of small lymphocytes were observed at the earliest signs of tumour cell damage. They were most likely the effectors of antineoplastic defence mechanisms. Secondly, a variety of numerous inflammatory cells including macrophages were observed later when the tumour was necrotic, and these cells were considered to be present as a response to tumour cell death.

Animals↗
PubMed1982

[Psychopathologic reactions after depot penicillin. Hoigné syndrome].

Intramuscular injections of depot drugs are sometimes followed by a few nonallergic reactions. Usually these are embolic toxic reactions, known as the Hoigné syndrome, following the application of depot procaine penicillin. Psychopathological symptoms predominate in such cases. The Hoigné syndrome that follows application of procaine penicillin is different to that following benzathine penicillin: lung embolism symptoms remain far in the background in the former case but are the dominant symptoms in the latter. The risk of death is slight in the case of the Hoigné syndrome following procaine penicillin application, but it definitely exists. There are probably many slight and misidentified forms of the Hoigné syndrome induced by procaine penicillin. So far, in 7 cases of Hoigné syndrome, we have observed that the syndrome is followed by certain psychopathological symptoms that we wish to call the Styx syndrome.

Delayed-Action Preparations↗