Biomedical subjects

J Vaage

Publications and source records attributed to J Vaage.

203 records · Page 12Linked to original sources

PubMedDate not supplied

Loss of spontaneous metastasizing potential in mouse mammary tumors.

Among 25 C3H/He and C3Hf/He spontaneous mammary tumors that all had produced pulmonary metastases in the autochthonous mice, and also produced pulmonary metastases during subsequent sequential syngeneic intramammary passages, three were observed to stop producing metastases. The specific investigation of the observed changes in behavior is described. When the tumors were re-started in serial intramammary passage from early, cryopreserved transplant generations, the loss of metastasizing potential reoccurred in the same, or in nearly the same, transplant generations. In one tumor from which three transplant lines had been established, the metastasizing potential was lost in all transplant lines during closely related transplant generations. It seems that a spontaneous reduction of malignant behavior in mouse mammary tumors may be an occasional neoplastic characteristic, and that the observed losses of metastasizing potential may have been determined by a programmed genetic change.

Animals↗

PubMedDate not supplied

Normal inhibition of mammary tumor metastasis in C3H/He mice.

The blood of normal C3H mice contains molecular factors that can rapidly lyse mammary carcinoma cells that enter the circulation. The cytotoxic effect of blood on tumor cells during incubation was most clearly demonstrated if fibrin formation was prevented. The conversion of the mammary carcinoma cells to ascites growth increased both the resistance to lysis in plasma and the ability to form lung colonies after intravenous injection. Mice that were surgically cured of numerous 9 mm tumors and survived for an average 10 months had a lower incidence (36%) of spontaneous metastases than mice that experienced one 30 mm tumor and survived for an average 8 weeks (65%). This is interpreted to mean that mice that retained their vitality by early surgical cures, could suppress the development of metastases by the action of normal serum factors that can destroy neoplastic cells that enter the circulation.

Animals↗

PubMedDate not supplied

Congenital abdominal aortic aneurysm in a young adult. Case report.

A 30-year-old man presented with threatened rupture of an infrarenal aortic aneurysm. Clinical and laboratory investigations revealed no traumatic, atherosclerotic, infectious or inflammatory cause. Histologic examination of the aortic wall showed cystic degeneration of the media. Consequently the case could be classified as congenital abdominal aortic aneurysm in an adult.

Adult↗

PubMedDate not supplied

A modified surgical technique for treatment of thoraco-abdominal aortic aneurysms.

Four patients aged 48-69 were operated upon for thoraco-abdominal aneurysms using a modified DeBakey technique reducing visceral ischemia to a minimum. The technique also pays attention to the preservation of the arterial supply to the spinal cord. All patients recovered and were discharged to their homes.

Adult↗

PubMedDate not supplied

Protective serum effects in tumor immunity.

Administration of serum presumed to contain tumor-specific antibodies supported the rejection in immunized mice of syngeneic fibrosarcoma implants which receded after an initial period of s.c. growth. Passive transfer of immune serum to unsensitized mice, sublethally radiated and injected with normal lymph node cells, protected the recipients against i.v. but not against s.c. implantation of syngeneic mammary carcinoma cells. Injection of immune serum assisted the recovery of mice in a state of tumor-induced specific immune depression induced by a large. s.c. mammary carcinoma implant and maintained after surgical cure by injections of serum presumed to contain soluble tumor antigen.

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