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Biomedical subjects

J Urbach

Publications and source records attributed to J Urbach.

33 records · Page 2Linked to original sources

Graduate medical education faces housestaff stress: institutional dynamics and group process.

The authors describe their efforts and experiences in presenting information on housestaff stress, dysfunction, and psychiatric morbidity to a committee of residency educators in their medical center. A complex group process emerged, which is discussed in the context of institutional background and "dynamics," the physician-psychiatrist relationship, and faculty role conflicts. Logistical problems in studying and intervening with such housestaff difficulties are presented, and formalized as a set of alternative approaches. A working plan is given in the form of ten initial goals. The authors' current approach, which is compared to "therapy for an institution," takes careful cognizance of resistances in the group process.

Academic Medical Centers↗

Congenital isolated folic acid malabsorption.

We report a case of congenital isolated malabsorption of folic acid, the first in a boy. Only seven previous cases have been reported, and we discuss two aspects--namely, the tendency to infection, with evidence of impairment of both cellular and humoral immunity, and the absence of neurological disturbances.

Anemia, Megaloblastic↗

Transient hyperphosphatasemia of infancy.

Very high serum levels of alkaline phosphatase were found in four children aged 13 to 24 months. No other abnormalities nor explanation for the raised enzyme levels were found. The origins of the elevated enzyme levels were shown by isoenzyme studies to be the liver in one case, the bone in two cases, and undetermined in one case. Serum alkaline phosphatase levels returned to normal after periods of 5 to 20 weeks. Awareness of these benign forms of hyperphosphatasemia will aid the physician in the differential diagnosis of elevated alkaline phosphatase levels.

Alkaline Phosphatase↗

Familial membranous subaortic stenosis.

Familial occurrence of membranous subaortic stenosis (MSS) is described in three families. The defect was found in 2 siblings in two of these families, and in 3 siblings of the third family. The importance of early diagnosis and treatment of MSS is emphasized. We suggest early evaluation of first-degree relatives of patients with MSS for the possibility of this defect.

Adolescent↗

Unusual presentation of Bruton's agammaglobulinemia--Pseudomonas sepsis.

A case of Pseudomonas sepsis and meningitis is described in a family in which the first child died in the first year of life after a fulminant Pseudomonas sepsis. In our patient, the second son, treatment was begun immediately after admission with clinical and bacteriological signs of Pseudomonas sepsis and continued for a 4-week period. Subsequent cessation of the treatment resulted in a relapse, with meningeal involvement. After specific therapy was added for his immunologic incompetence, as well as subsequent antibiotic treatment, the patient was cured of his prolonged illness.

Agammaglobulinemia↗

Hypertrophic cardiomyopathy in children with end-stage renal disease and hypertension.

Cardiac function was evaluated by echocardiography (echo) in ten paediatric patients, 2.5 to 15 years of age, maintained on chronic dialysis. All had moderate to severe hypertension despite intensive antihypertensive medication. Four of ten patients showed, on echo, asymmetric septal hypertrophy (ASH) typical of hypertrophic cardiomyopathy (HCM). Two also had signs suggestive of outflow obstruction. Primary cardiomyopathy was excluded by a family survey of first-degree relatives. The incidence of HCM in our series is impressive (40%). The pathogenesis of this cardiac lesion in uraemia is unknown; long-standing severe hypertension may play a role. Early recognition of this form of cardiomyopathy has important clinical considerations. Echo should become a routine examination in the diagnosis, follow-up, and treatment of children with end-stage renal disease.

Adolescent↗

The effect of a short-term course of antibiotic prophylaxis on patients undergoing total abdominal hysterectomy.

A prospective double-blind study of antibiotic prophylaxis in 69 patients undergoing total abdominal hysterectomy was conducted. A short, 1-day course of cefazolin prophylaxis effectively decreased febrile morbidity, serious postoperative infections and hospital stay. Resistant infections or delayed infections were not encountered in this series of prophylactically treated patients. There was no difference between the active drug group and the placebo group in the frequency with which aerobic Gram-negative rods and the incidence of cephalosporin-resistant organisms cultured postoperatively.

Adult↗

Ovarian hematoma and hemoperitoneum complicating anticoagulant therapy.

The diagnosis and management of ovarian hemorrhage complicating anticoagulant therapy is discussed and a case presented. The patient, who had undergone mitral valve replacement and was receiving chronic anticoagulation treatment, was admitted with signs of intraperitoneal bleeding from a ruptured ovarian hematoma. This complication must be considered in the menstruating female who is receiving anticoagulant therapy. Long-term anovulatory therapy could possibly avoid this potential ovarian hemorrhage.

Adult↗