Biomedical subjects
Publications and source records attributed to J U Felding.
In a number of Danish ENT departments, X-ray examination of the paranasal sinuses has been a routine procedure in cases of severe epistaxis of uncertain genesis, two to four weeks after its treatment has been completed. The object has been to rule out cancer of the nose and/or paranasal sinuses. In the present study, the value of this procedure was assessed.
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A prospectively planned, epidemiologic and longitudinal study of 329 children born in 1972 and living in a Danish provincial municipality was undertaken. All had tympanometric screening by the age of 3, 6 and 9 years. The screenings took place in January 1976, January 1979, and January 1982. The aims of the study were to compare the point prevalences of abnormal tympanometry in a normal population and to evaluate the prognosis of the different curve-types at 6 years of follow-up. Accordingly there is major improvement in middle ear status during the first three years in school. Type A tympanograms have a better prognosis than all other types. Tympanograms with light (type C1) and severe (type C2) negative middle ear pressure have similar prospects. Patients with the poorest prognosis have type B tympanograms, 70% of type B tympanograms at age 9 years were also type B at age 3 years.
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Two series of consecutive, nonrelated patients with middle ear cholesteatoma verified by operation were tissue typed for human leukocyte antigens (HLAs) in order to demonstrate any associations. The first series (102 patients) showed only a possible increase of HLA-B8 and HLA-A2. Because HLA-B8 is one of the antigens most often involved in associations with organ-specific autoimmune diseases, and because of the close relationship between HLA-B8 and HLA-DR3, the second series (48 patients) was tissue typed for these two antigens. This second series showed a similar increase of HLA-B8/DR3, but the difference was not statistically significant.