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Biomedical subjects

J Treasure

Publications and source records attributed to J Treasure.

93 records · Page 6Linked to original sources
PubMedDate not supplied

Set shifting in anorexia nervosa: an examination before and after weight gain, in full recovery and relationship to childhood and adult OCPD traits.

Deficits in set shifting tasks are present in anorexia nervosa (AN), but it is not known whether these deficits are traits independent of current disease or nutritional status or merely a temporary consequence of starvation or psychopathology. The aims of the present study were to determine if set-shifting sub-optimal performance are state or trait-related by examining set shifting in patients with current or past AN, and the extent of association of these deficits with obsessive compulsive traits and behaviours. To achieve this we examined set shifting abilities in three groups of subjects: (a) AN patients with current illness, prior to receiving treatment (AN); (b) people with past AN currently in long term recovery (ANRec) and a healthy comparison group (HC). We also longitudinally followed up a subset for the AN group who showed weight recovery in response to in patient treatment (ANWR). We administered a group of set shifting tests, which included cognitive, perceptual and motor shifting tasks. A semi-structured interview was obtained to ascertain obsessive compulsive personality disorder (OCPD) traits as a child and adult. Set-shifting difficulties were observed in the AN group, but to a lesser extent in the ANRec group. In the AN group these difficulties did not show any improvement follow re-testing after weight recovery. Performance on set shifting tasks was associated with childhood rigidity and inflexibility. Some aspects of set shifting sub-optimal performance in AN appear to be a trait rather than a state marker.

Adult↗
PubMedDate not supplied

Role of dietary potassium in the treatment of hypertension.

This review summarizes the historical development and recent resurgence of interest in dietary potassium as a factor in hypertension. Some epidemiologic evidence has suggested that potassium intake by humans may be inversely related to the level of arterial blood pressure. Other studies have suggested that a marked reduction in the Na+/K+ ratio of the human diet reduces the blood pressure of normotensives. Further, the administration of high potassium diets has resulted in a lowering of blood pressure in some animal models of hypertension. Several possible mechanisms for this putative antihypertensive effect are evident. Some observations suggest that potassium could act as a diuretic agent and thereby reduce extracellular fluid volume, which in turn could result in decreased blood pressure. An alternative mechanism of action is that potassium may alter the activity of the renin-angiotensin system and reduce angiotensin influences on vascular, adrenal, or renal receptors. Other evidence supports the possibility that potassium modifies central or the peripheral neural mechanisms that regulate blood pressure. In addition, high potassium diets could reduce blood pressure by relaxing vascular smooth muscle and reducing peripheral vascular resistance directly. Although diets high in potassium content do appear to modify arterial blood pressure under some circumstances, particularly in salt-dependent hypertension, a high potassium intake has not always attenuated blood pressure in all models examined. Further, evaluation of these data do not allow definite conclusions regarding a common mechanism through which potassium exerts these effects.

Animals↗