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Biomedical subjects

J Traserra

Publications and source records attributed to J Traserra.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Hearing and diabetes.

The results of the audiological evaluation of 47 diabetics are presented. The patients were divided into two groups: A (17/47), type I early diabetics, and B (30/47), type I chronic diabetics. The evaluation included puretone audiometry, high-frequency audiometry and auditory brainstem response. There was a control group consisting of 30 healthy subjects. In group 1 the audiological assessment was normal in all cases. In group 2 hearing loss was found in 30% of cases (9/30). Hearing loss was significantly correlated with age (p = 0.0019) and duration of diabetes (p = 0.0143), but not with diabetic microangiopathy (p = 0.1506). The authors conclude that hearing loss is not a usual feature in diabetic patients. When present, hearing loss should be attributed to the effect of diabetes on the age-related physiological impairment of the inner ear. The pathogenic mechanisms remain obscure.

Adolescent↗
PubMedDate not supplied

Radiotherapy in the maxillary hemangioma.

We present the case of a large maxillary hemangioma treated by radiotherapy. Only 4 cases managed by radiotherapy have been reported in the literature, and most authors negate the radiosensitivity of the tumor. In our patient, the outcome was excellent; by 6 months tumor reduction was more than 50%. This is the first case referred to in the literature whose radiotherapy response was evaluated by magnetic resonance imaging. We describe the clinical and imaging findings of this very rare tumor and its evolution. We also comment on the literature reviewed.

Adult↗
PubMedDate not supplied

[Ethmoidal metastasis of renal adenocarcinoma].

The sinonasal tract and, more specifically, the ethmoid sinus, are uncommon sites for metastatic tumors. Fewer than 100 cases have been reported in the world literature. We report the case of a 65-year-ol woman who underwent nephrectomy and adrenalectomy for renal cell carcinoma (hypernephroma) with adrenal metastasis. Four months later the patient was seen for repeated epistaxis and nasal obstruction, which was diagnosed as ethmoidal metastasis of renal adenocarcinoma in a second biopsy. The second metastasis was removed by lateral rhinotomy but recurred six months later. Palliative surgery was performed and the patient died eight months later from brain metastases. Therapeutic strategies for metastatic nasal tumors are reviewed.

Adenocarcinoma↗
PubMedDate not supplied

[Single fibrous tumor of the parapharyngeal space].

A solitary fibrous tumor (SFT) of the parapharyngeal space presented with local symptoms (hearing loss, nasal obstruction, and paralysis of the soft palate and tongue). SFT, originally described as a mesothelial tumor of the pleura, now is recognized as a mesenchymal tumor that occurs in different locations. In the head and neck region, about 50 cases have been reported. This is the fifth published report of an SFT of the parapharyngeal space. The diagnosis was confirmed by immunohistochemical (positivity for vimentin, CD34, and CD99) and ultrastructural markers (fibroblastic characteristics).

Aged↗
PubMedDate not supplied

[Metastasis of systemic origin in otorhinolaryngology].

INTRODUCTION: In the upper respiratory-digestive tract cancer is always primary. Such cancer is very common, but other extremely rare secondary cancers may be found. DEVELOPMENT: We studied our own patients and some published in the literature: cancer of the kidney with metastases in the paranasal sinuses and cancer of the breast metastasizing to the temporal bone. We review the bibliography on these rare metastases. CONCLUSIONS: In all cases of otorhinolaryngological cancer a detailed history should be taken, with special reference to previous neoplasms. It is particularly important to study and review any history of renal, breast or prostate tumors with regard to the primary tumor and the receptor organs of metastases, the paranasal sinuses and temporal bones. The most difficult problem occurs when the primary tumor is present but undiagnosed. Therefore, in all cases of cancer of the paranasal sinuses and temporal bones, before treatment is started the kidney, prostate, breast and other organs above and below the diaphragm where tumor may be present should be examined. The prognosis of these metastases, which are almost always fatal, is very poor so that often treatment is only palliative rather than aggressive.

Adenocarcinoma↗
PubMedDate not supplied

[Naso-sinusal aspergillosis. Review of the literature and description of 2 cases].

The number of cases of NSA is increasing owing to a better knowledge of the disease and the high number of patients with impaired immunologic defense mechanism. Two cases are presented. A valoration of the different diagnostic and therapeutic procedures and also the different etiologic and clinical possibilities is done.

Amphotericin B↗
PubMedDate not supplied

[Tinnitus in the diagnosis and prognosis of ototoxicity].

The prognostic value of tinnitus about the occurrence of hypoacusia in a patient undergoing an ototoxic treatment is not know. Ninety-five patients treated with cisplatinum, a cocleotoxic drug, have been studied to evaluate the percentage of patients with tinnitus, to assess the characteristics of these tinnitus and to know if there is a relationship between its occurrence and the degree of hearing loss that appears after treatment. Thirty-six patients (37.9%) had tinnitus, and there was not a statistically significant relationship between this symptom and the hearing loss. Therefore, tinnitus cannot be used as a prognostic factor for hypoacusia in patients undergoing treatment with cisplatinum.

Cisplatin↗
PubMedDate not supplied

[Ototoxicity of desferrioxamine in hemodialyzed patients].

A prospective study performed on 37 patients with end-stage renal disease who required treatment with deferoxamine is presented. Three patients presented a sudden sensorineural hearing loss, with tinnitus in one case, which was demonstrated to be of cochlear origin. All patients recovered auditory function completely after treatment was discontinued.

Adult↗
PubMedDate not supplied

[Adaptable and portable cephalometric devices: a new method in obtaining cephalometrics].

Cephalometric radiographic explorations are widely recommended in the diagnosis of the obstructive sleep apnea syndrome (OSAS). In order to improve their diagnostic value, its practice in the upright and supine position has been proposed. A rigorous practice of cephalometric requires the employment of cephalometric devices in order to assure a correct positioning of the head and provide reliable X-ray pictures, comparable within reasonable accuracy over a period of time. The commercialized cephalostats are often expensive due to the structural conditions needed for their development and usually they not allow the simultaneous practice of upright and supine cephalometric. In this paper we describe a cephalometric adaptable device, developed by our research group, that may solve such problems.

Cephalometry↗
PubMedDate not supplied

[Carotid paraganglioma: a case report].

Carotid paraganglioma are tumors arising from chemoreceptor paraganglioma cells. These cells have proved to have an embryologic origin from the neural crests. Due to their low incidence these tumors are not an habitually found in daily practices. We present a case of carotid body paraganglioma diagnosed by clinical exploration, CT scan, magnetic resonance imaging and magnetic resonance angiography which was successfully treated by surgery. The diagnostic and therapeutic difficulties present in these tumors are discussed.

Angiography↗
PubMedDate not supplied

[Neurosensory hearing loss associated with ischemic heart disease. Features and prognostic values].

The aim of this study was to verify the supposed pathological hearing loss in those patients with ischemic heart disease, as well as to determine its features and possible clinical usefulness. Two groups were made: group A (n = 65), patients admitted for acute episode of ischemic heart disease, group B (n = 60), patients without cardiac or auditive disorders. Auditive assessment included standard PTA and Bera. Cardiologic evaluation was made through cardiac catheterism with coronariography. Results confirm the existence of a clinical association between "perceptive hearing loss" and "ischemic heart disease", independently of the age, with a characteristic pattern of hearing loss, and also show the existence of a high risk subgroup within the population with coronary risk.

Acute Disease↗
PubMedDate not supplied

Prognostic value of TPS in patients with head and neck malignancies: comparison with SCC.

TPS and SCC serum levels were evaluated in 113 patients with primary tumors, 19 with relapse and 59 with no evidence of disease after radical treatment. Abnormal serum levels were found in 37% and 33% of patients with primary untreated tumors and in 53% and 59% of patients with relapse, respectively, using 100 U/L and 2.5 ng/ml as the upper limit of normality for TPS and SCC, respectively. Either tumor marker was abnormal in 57.5% of primary tumors and in 74% of patients with relapse. TPS and SCC serum levels were related to nodal involvement, with significantly higher levels in patients with nodal invasion (p < 0.02 and p 0.001, respectively). No relationship was found between tumor size, age or histological grade and SCC or TPS values. Pretreatment TPS and SCC serum levels had prognostic interest in patients with locoregional tumors, with a significantly shorter disease-free interval (DFI) in patients with abnormal values (p < 0.01 and p < 0.02, respectively). When tumor marker levels and nodes were simultaneously evaluated, a trend toward shorter DFI in patients with abnormal serum concentrations was found, with no statistical significance. By contrast, TPS and SCC were useful in prognosis in node-negative patients (p < 0.02 and p < 0.001, respectively). Likewise, using both TAAs simultaneously, it is possible to increase prognostic information. Patients with TPS and/or SCC abnormal levels had a significantly lower DFI than those patients with normal values, in both node positive and negative patients (P < 0.01). In summary, TPS and SCC are useful TAAs in patients with head and neck malignancies. Likewise, with the simultaneous use of SCC and TPS, the TAA utility in this malignancy increases in the prognosis as well as disease follow-up.

Antigens, Neoplasm↗
PubMedDate not supplied

[Amoxycillin-clavulanic acid and cefuroxime axetil in the treatment of acute sinusitis. A clinical, radiological and bacteriological evaluation].

Cefuroxime axetil (CAE), an orally absorbed product of cefuroxime, and amoxycillin/clavulanate (AAC), were evaluated for their efficacy and safety in the treatment of acute sinusitis. A total of 47 patients were enrolled in a randomized study to compare cefuroxime axetil 500 mg. b.d. for 8 days (25 patients) with amoxycillin/clavulanate 500 mg. t.d.s for 8 days (22 patients). All patients were evaluable for clinical, radiological and bacteriological response. Of 25 clinically assessable patients treated with CAE, 24 were cured, 1 improved and 1 relapsed (96% success rate). Of 22 assessable patients given AAC, 14 were cured and 8 improved (100% success rate). Two out of 25 (8%) patients treated with CAE experienced drug-related adverse events, including 4% with diarrhoea. In the AAC group, 3 out of 22 (13%) patients had a drug-related adverse event, including 13% with diarrhoea. In conclusion, CAE appears to be as safe and effective as AAC in the treatment of acute sinusitis.

Acute Disease↗
PubMedDate not supplied

Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local-regional treatment in pyriform sinus cancer.

AIMS AND BACKGROUND: The purpose of this study was to retrospectively compare different approaches including neoadjuvant chemotherapy. METHODS: Ninety-six consecutive patients with pyriform sinus squamous cell carcinoma with no distant metastases were entered. The first 48 patients were treated with surgery plus postoperative radiation therapy (50-60 Gy) over cervical lymphatics. The next 48 patients were treated by induction chemotherapy with two courses of cisplatin, 120 mg/m2 i.v. day one, plus bleomycin, 20 mg/m2/day for 5 consecutive days in 24-hr i.v. perfusion followed by definitive surgery and postoperative radiation therapy as in the first therapeutic group. RESULTS: Definitive surgery was performed in 38 control vs 39 neoadjuvant patients. Complete response was observed in 9 (18.7%) and partial response in 32 (66.7%) of 48 chemotherapy-treated patients. Partial plus complete response was seen in 41 (85.4%) of the 48 patients. Comparison between controls versus chemotherapy-treated groups showed persistence of the disease in 10 vs 9 patients; local-regional relapses in 21 versus 14 patients; and distant metastases in 4 vs 2 patients. Median survival was 12 vs 40 months. Survival curves were statistically better in neoadjuvants than in controls (P < 0.025). CONCLUSIONS: Multidisciplinary therapy slightly decreases the rate of local-regional relapses and distant metastases and should improve survival in this set of pyriform sinus cancer patients.

Adult↗
PubMedDate not supplied

[Prospective double-blind randomized study of the efficacy and tolerance of topical ciprofloxacin vs topical gentamicin in the treatment of simple chronic otitis media and diffuse external otitis].

A prospective, randomized double-blind study was made of topical ciprofloxacillin (0.5%) compared with topical gentamicin (0.3%) in the treatment of simple chronic otitis media (COM) and diffuse external otitis (DEO). The study included 47 patients with COM and 54 patients with DEO. Success rates in the COM subgroup were 95% for ciprofloxacillin and 96% for gentamicin (p = 0.082), and in the DEO subgroup, 87% for ciprofloxacillin and 79% for gentamicin (p = 0.19). Both drugs were well tolerated and there was no significant change in audiometric measurements with either medication in either group. Therefore, ciprofloxacillin is at least as effective as gentamicin in such ear infections and has no potential ototoxic effect.

Administration, Topical↗
PubMedDate not supplied

[Topographic diagnosis of hearing loss in patients with ischemic heart disease. Use of high-rate brain stem evoked response audiometry].

Hearing loss in patients with ischemic heart disease traditionally has been attributed to atheromatous cerebral vascular disease. In this study, the site of the auditory lesion was sought in patients with ischemic heart disease and perceptive hearing loss. Standard brainstem evoked response audiometry (BSER) with increased stimulation rate (ISR) were performed. Sixty-seven patients admitted for coronary artery disease were examined. Fifty-seven recordings were complete and evaluable. All the cases of hearing loss were endocochlear. In 4 patients. BSER and ISR detected subclinical retrocochlear lesions that were compatible with ischemic disease. The results suggest that selective early cochlear ischemia can occur in young persons with heart disease. The sensitivity of BSER with ISR for detecting ischemic brainstem lesions was confirmed.

Adult↗