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Biomedical subjects

J Trachtenberg

Publications and source records attributed to J Trachtenberg.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Male genital trauma: diagnosis and management.

Trauma to the male external genitalia represents a serious injury that must be managed promptly and completely. To avoid long-term loss of function, disability, and psychologic effects, wounds should be carefully assessed, protected from further injury, and referred for surgical and social follow-up.

Emergency Medical Services↗
PubMedDate not supplied

Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase fish analysis.

The way in which cytogenetic aberrations develop in prostate cancer (CaP) is poorly understood. Spectral karyotype (SKY) analysis of CaP cell lines has shown that they have unstable karyotypes and also have features associated with chromosomal instability (CIN). To accurately determine the incidence of de novo structural and numerical aberrations in vitro in CaP, we performed SKY analysis of three independent clones derived from one representative cell line, DU145. The frequent generation of new chromosomal rearrangements and a wide variation in the number of structural aberrations within two to five passages suggested that this cell line exhibited some of the features associated with a CIN phenotype. To study numerical cell-to-cell variation, chromosome 8 aneusomy was assessed in the LNCaP, DU145, and PC-3 cell lines and a patient cohort of 15 CaP primary tumors by interphase fluorescence in situ hybridization (FISH). This analysis showed that a high frequency of numerical alteration affecting chromosome 8 was present in both in vitro and in CaP tissues. In comparison to normal controls, the patient cohort had a statistically significant (P<.05), greater frequency of cells with one and three centromere 8 copies. These data suggest that a CIN-like process may be contributing towards the generation of de novo numerical and structural chromosome abnormalities in CaP.

Chromosome Aberrations↗
PubMedDate not supplied

Issues for patient and family.

This article explores managed care in the 1990s from the perspective of patient and family. This perspective is a complicated one because there is no one managed care program and there is even more diversity among patients and families. Four major issues are singled out for discussion: choice, access, cost, and quality of care. Also discussed are the skills needed by patients and families, as well as health care professionals, that are taking on growing importance in the managed care environment: communication, negotiation, and advocacy.

Costs and Cost Analysis↗