Search PubMed⌕ Search

Biomedical subjects

J Tostain

Publications and source records attributed to J Tostain.

68 records · Page 4Linked to original sources

[Management of the upper urinary tract in boys with posterior urethral valves (65 cases) (author's transl)].

The authors study the management of the upper tract in 65 boys with posterior urethral valves from 1965 through 1978. Their behaviour has changed with time. At the beginning of their experience they used systematically urinary cutaneous diversion (18 cases : 9 good results -- 4 deaths -- 5 poor results). In a second period they used extensive surgical reconstruction at the same time as with destruction of the valves according to H.W. Hendren. Results were very bad : 5 cases: 1 good result, 3 poor results -- 1 death. During the later years of this study (1973 to 1978) 42 boys were managed by primary destruction of the valves. 22 required only valve ablation and recovered with a good upper tract. 6 severely ill infants who did not respond to valve ablation alone were nephrostomy (2) or ureterostomy (4) diverted (4 good results). In 14 additional patients a ureteral reimplantation was required : 8 successes -- 6 failures. Our experience supports the thesis that after primary resection alone the severely dilated and tortuous ureters usually improve strikingly with time. A period of watchful waiting before undertaking ureteral reimplantation is recommended. Measurements of ureteral pressure also are beneficial in determining the need for surgical intervention (Whitaker). Temporary ureteral diversion has a place in the severely ill patient who has not responded to valve resection.

Child↗

[Progression and severity of arterial hypertension in aged subjects (12 cases].

We analyzed retrospectively 12 patients, aged from 63 to 73 years, with renovascular hypertension due to unilateral or bilateral atheromatous lesions (4 out of 12). Malignant or accelerated hypertension with multiple visceral involvement was frequent (8 out of 12). The proximal lesions (stenosis) of the renal arteries were rapidly progressive, leading to complete thrombosis in 8 cases. Five patients received medical treatment only, but 2 worsened their GFR and 2 had a poor blood pressure control. Of the 5 patients who underwent renal surgery 2 had nephrectomy, 2 had an aorto-renal bypass and 1 a bypass plus nephrectomy; 2 of them recovered a normal GFR, but 2 died in the post-operative period. Three patients had selective embolization of a renal artery, but only one was definitely improved. So far, the treatment of such cases still is very difficult.

Aged↗

[Migration of cement into the bladder after total hip replacement (author's transl)].

The authors report a case of total hip replacement followed by early infection. The prosthesis was removed after several months but despite this a fistula persisted. Four years later, signs of bladder infection appeared. The patient was operated on and a piece of cement was found inside the bladder and removed. The relationship between the infection and the migration of cement into the bladder is discussed. It was recalled that nay intrapelvic protrusion of cement should be avoided in the course of a total hip replacement.

Aged↗

[Injuries of the pancreas in children. Apropos of 4 cases].

The authors report 4 cases of pancreatic injury in children : 1 distal transection, 2 simple contusions and 1 pseudocyst of the head. They review the diagnostic approach to and treatment which is centered on the state of the pancreatic duct: external drainage when the pancreatic duct is safe, simple contusion or even pseudocyst, distal pancreatectomy, with or without splenectomy when the pancreatic duct has been transected in a complete pancreatic transection complicated or not with a pseudocyst.

Adolescent↗

[Renovascular hypertension in a child, originating in a lower pole aberrant renal vessel dysplastic stenosis (author's transl)].

Renovascular hypertension in a 15-years-old girl, originating in a lower pole aberrant renal artery stenosis by fibromuscular hyperplasia. Microsurgical management by polar artery reimplantation in the renal artery. Unknown evolutivity and diffusion of arterial dysplasias explain the more and more distal repairs reported in literature concerned with renovascular hypertension in infancy and childhood. Nephrectomy and segmental resection are now only done when revascularization is not possible.

Adolescent↗

[Congenital recto-urethral fistulas in adults. Two cases (author's transl)].

Presentation of two cases of imperforate anus managed in infancy. In first case, at age of 19, surgical closure of recto-urethral fistula associated to excision of a rectal pouch complicated with infected lithiasis and renal damage provides definitive therapy. In second case, recto-urethral fistula was well tolerated for more than 50 years without renal damage. Simple removal of a prostatic lithiasis partially obstructing fistula, provided fair good result. Etiology of these fistulae, well known in pediatric patients, is then discussed. Management must be adapted to complaints and risks.

Adult↗

[Contribution of 99mTc MAG3 in hypertension in an elderly subject with renal artery thrombosis].

To ascertain the responsibility of renal artery thrombosis for the genesis of arterial hypertension, the methods available are not sufficiently sensitive and reproducible, and the residual revascularization maintained by a vicarious arterial network is not easy to demonstrate. Renal scintigraphy with technetium 99m-labelled mercaptoacetyltriglycine (MAG3) was performed in 4 old and severely hypertensive male patients with chronic thrombosis of one renal artery. With this tracer the thrombotic kidney was detected lately and weakly at the vascular and nephrographic stages. When the functions of both kidneys were compared, that of the affected kidney was always estimated at less than 5%. At the excretory stage a residual activity could be detected in the kidney with renal artery thrombosis. Owing to the specific biophysical behaviour of the tracer, MAG3 scintigraphy coupled with arteriography and assays of plasma renin activity in the veins contribute to the decision concerning nephrectomy.

Aged↗

Flow cytometric analysis of antigen expression in malignant and normal renal cells.

UNLABELLED: Flow cytometry allows quantitative analysis of cancer cells. The aim of this study was to make a quantitative study of antigen expression in malignant and normal renal cells in order to find the efficient monoclonal antibodies (mAbs) for labelling renal cancer cells. MATERIAL AND METHODS: 15 malignant and adjacent normal renal tissues and three renal carcinoma cell lines (ACHN, A704 and CAKI-2) were analyzed. The malignant and normal renal tissues were dissociated mechanically into cell suspension. The mAbs and isotype controls were used for immunochemical labelling. The stained cells were analyzed by flow cytometry. RESULTS: Renal tumor associated antigen G 250 was frequently detected in malignant renal cells but not in normal renal cells. Renal tumor associated antigen gp200 recognized by 66.4.C2 and PN-15 was frequently detected in malignant cells, normal renal cells and also in all three carcinoma cell lines. Epithelial antigens were strongly positive in normal renal cells. Compared with MOC 31, Ber-EP4 and E 29, W-lD9 was mostly reactive to malignant renal cells. VU-1D9 was strongly positive on ACHN and A704. The carbohydrate carcinoma antigens CA 125, DF3 and Sialyl Lewis(a) were detectable in some of the malignant and normal renal cells. Sialyl Lewis(a) could be weakly detected on ACHN and A 704. Pan-cytokeratins and cytokeratin (CK) 8 were strongly expressed in malignant and normal renal cells and in all three cell lines. CONCLUSION: Our results indicated that G 250, 66.4.Ca, PN-15, VU-1D9, MNF116 and anti-ckg were efficient mAbs for labelling renal cancer cells. Their potential clinical application by flow cytometry should be explored.

Adult↗

[Surgically curable hypertension (author's transl)].

A case of hypertension was cured by simultaneous surgical treatment of an obstructive urolithiasis associated with a pheochromocytoma. Primary devascularization of the adrenal tumor, reducing blood pressure and cardiac rhythm variations was allowed by preoperative arteriography.

Adrenal Gland Neoplasms↗

[Urinary infections in pregnant women].

Urinary tract infection is frequent during pregnancy with a high potential risk for mother and child. Based on a review of the literature and a retrospective survey conducted in 20 representative French university hospitals during 1993, the authors propose a practical review designed to standardize the therapeutic approach to this disease. They define a high-risk group which requires systematic screening and close surveillance during pregnancy. They evaluate the need for complementary investigations in relation to the 3 clinical presentations encountered (asymptomatic bacteriuria, cystitis and acute pyelonephritis) taking into account their respective adverse effects. The therapeutic modalities of the three clinical forms are then described, including drainage of the urinary tract.

Acute Disease↗