Systemic contact dermatitis from erythromycin.
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Biomedical subjects
Publications and source records attributed to J Toribio.
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We report on a patient in whom prolonged therapy with etretinate was associated with the appearance of disseminated nodules, whose histopathologic study showed a sarcoid-like granuloma. Although the role of etretinate in the occurrence of this granulomatous reaction is not proven, we speculate on possible mechanisms of such a link.
A case of hyperpigmentation distributed in streaks and whorls was recently delineated and separated from a confusing number of pigmentary disorders. A 13-year-old boy had hyperpigmented, reticulate spots on his trunk and neck in a linear and whorled distribution following the lines of Blaschko. Onset was at age 1 year. Histologically, the spots showed increased melanin in the basal layer of the epidermis, but no increase in melanocytes, incontinence of pigment, or melanophages were seen in the dermis. The karyotype was 46,XY and there was no evidence of chromosomal mosaicism or chimerism. This entity represents a disorder separated recently from other pigmentary alterations that follow Blaschko lines, such as Bloch-Sulzberger incontinentia pigmenti, hypomelanosis of Ito, early systematized epidermal nevus, and chimerism.
We report the case of a 47-year-old male with Kartagener's syndrome (KS; situs inversus, bronchitis and sinusitis) who showed three types of cutaneous lesions: recurrent outbreaks of nummular eczema, recurrent deep folliculitis and two episodes of pyoderma gangraenosum. The patient had also IgA gammopathy of undetermined significance. This is the second case of KS associated with cutaneous lesions published so far and suggests that primary ciliary dyskinesia syndromes may have skin symptoms.
A case of a giant solitary trichoepithelioma is reported. The tumor was located on the thigh, extending from the deep dermis to the subcutaneous tissue with no epidermal contact, and showed a large central cystic cavity that measured 9 cm x 4 cm. We review the cases published under this and other names.
The lichen planus follicularis tumidus was described by Belaich et al. in 1977, and we have found 13 cases published so far. We report two cases we have recently seen, one of them with multiple lesions on the head, and the other with a temporo-frontal lesion.
The histopathological aspects of seborrheic keratosis have been studied in order to establish a basis to their classification upon structural morphology and cytology. The 210 seborrheic keratosis studied could be classified in several patterns among which we must point out the three most important ones: hyperkeratotic, adenoid and acanthotic. This last one can offer two very different images: uniform acanthotic (this one including at the same time, a variant of "small basal cells") and reticular acanthotic. Special mention has to be made as well to the activated and pure forms which, though being the result of evolutive accidental phenomena, no doubt they have very particular and distinctive histopathological aspects. Further, other variants are discussed such a clonal and acantholytic seborrheic keratosis, as well as the significance of inverted follicular keratosis and of melanoacanthoma.
We report two cases of Dowling-Degos' disease, one affecting the vulvovaginal semimucose, and one associated to a terminal malignant neoplasia. We remark the importance of this knowledge in order to distinguish it from malignant acanthosis nigricans or other patterns of melanosis or lentiginosis when located within mucose or semimucose, specially at the genitals. All cases associated to malignant neoplasia described are emphasized. However Dowling-Degos' disease is considered to be a nonparaneoplasic genodermatoses, this association should be taken into account.
One hundred cases of chronic idiopathic urticaria (CIU) were studied to determine the incidence of leukocytoclastic vasculitis (LV) and the clinical and laboratory data that might indicate its presence. LV was found in 12 patients, none of whom had either clinical or laboratory data to suggest its presence. These results suggest that a small percentage of patients with CIU. 12% in this series, have LV without either clinical or laboratory signs of its existence.
We have had the opportunity to study an dermatophyte isolated from the face of a woman, as a result of a fall on the ground. We identified the strain as Trichophyton proliferans whose characteristics, together with a review of the works published about this dermatophyte, lead us to believe that we are dealing with an independent species and not a synonym of T. mentagrophytes var. erinacei.
We cared for a patient with woolly-hair nevus (WHN) with hair of reduced diameter seen as oval shaped on transverse section. Scanning electron microscopy revealed a longitudinal canal along the length of the hair shaft. Although the association of WHN and epidermal nevus has been described previously, this report of their localization in the same site is, to our knowledge, the first in the literature.
Four cases of segmental neurofibromatosis (SNF) are reported. It is a rare entity considered to be a localized variant of neurofibromatosis (NF)-Riccardi's type V. Two cases are male and two female. The lesions are located to the head in a patient and the other three cases in the trunk. No family history nor transmission to progeny were manifested. The rest of the organs are undamaged.
We reviewed the clinical and histopathologic findings in 25 Spitz's nevus who were evaluated at our institution from 1980-1988. 18 cases in patients aged 20 years or less and 7 cases in adults. 14 are female and 11 are male. Represent the 3.88% of melanocytic nevi etude in the same time. Eosinophilic globules were find in 64% of the cases. We include a pigmented spindle cell nevi (non-Spitz), we thinks is a variant of Spitz's nevus.
A case of porokeratotic eccrine ostial and dermal duct nevus (PEODDN) affecting all 4 extremities is described. Clinically, palmo-plantar lesions resembled those of nevus comedonicus and the remaining lesions those of linear verrucous epidermal nevus. Histologically, all lesions were identical with cornoid lamellae in the eccrine ostia and epidermal ducts.
A case of perforating pilomatricoma is described. A few published cases have shared the following features: rapid development, reddish exophytic clinical appearance with surface alterations suggestive of perforation, relatively shallow location making contact with the epidermis, and the occurrence of transepithelial elimination phenomena.
The taxonomy of the dermatophyte Trichophyton megninii has been the subject of much discussion since it was first isolated by Sabouraud in 1893. Initially he named it Trichophyton à culture rose and later T. rosaceum. It has been confused with the Microsporum (Epidermophyton) gallinae described by Megnin. Nowadays most mycologists consider T. rosaceum to be a synonym of the T. megninii, although some French authors still use Sabouraud's denomination. It is an exclusively anthropophilic dermatophyte with a broad geographic distribution, but in general a low incidence in most countries, except in Portugal, Corsica and Sardinia where it causes infections of both hairy and glabrous skin zones and nails in humans. T. megninii is an uncommon cause of ringworm in Spain and is mainly restricted to Galicia, and even there the incidence is low; it has been isolated only five times in our clinical practice with two more cases described previously in the literature, and predominantly affects females. Case reports show that it produces slowly evolving lesions with little local symptomatology on the scalp and is recalcitrant to conventional antifungal treatment. Its identification in culture should be based on the macroscopical appearance of the colony and by its absolute requirement for 1-histidine.
We report a case of tubular apocrine adenoma located on the scalp, with characteristics of syringocystadenoma papilliferum in the superior part of the lesion. An interesting feature of the growth is its connective tissue involvement.