Percutaneous transhepatic portal catheterization was performed in 68 cases of liver diseases in the 2 year period from 1978 to 1980. The Chiba University method was modified. Portal vein catheterization was successful in 61 cases (90%). Selective splenic vein catheterization was successful in 55 of the 61 cases (90%) and selective superior mesenteric vein catheterization in 59 cases (97%). The liver was punctured an average of 4.6 times in order to successfully insert the catheter into the main portal vein, and the number of punctures was less than 10 in 57 of the 61 cases (93%). The portal vein pressure was 310+/-67 mm H2O in idiopathic portal hypertension (8 cases), 290+/-83 in liver cirrhosis (33 cases), 193+/-71 in chronic hepatitis (7 cases) and 166+/-50 in fatty liver (4 cases). Portal vein pressure rose from 205+/-75 to 380+/-55 mm H2O in 11 cases after forced Valsalva maneuver. No major complications were encountered.

Catheterization↗

PubMed1980

Studies on acid protease fractions and gastric mucosal atrophy. 3. Special reference to peptic ulcers.

In combination with routine gastric secretion test and endoscopic congo red test, alkali labile pepsin (ALP) and alkali stable pepsin (ASP) were separately determined in total of 41 patients with peptic ulcer including 20 gastric (GU), 12 duodenal (DU) and 9 gastroduodenal ulcers (GDU), and in 10 normal controls. In both of basal and tetragastrin stimulated states, percent of ASP in total acid protease (%ASP) was increased in order of GU, GDU, normal control and DU with a close relation to the dimension of acid secreting area determined by endoscopic congo red test. Percent ASP was decreased after tetragastrin provocation in all disease groups. GU had high % ASP and low maximal acid output (MAO), GDU had high %ASP and high MAO, and DU showed low %ASP and high MAO.

Adult↗

PubMed1977

Role of hydrophobic interaction in hapten-antibody binding.

The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more than -5.8 Kcal/mol to the free energy of binding. This value was consistent with the free energy change expected from the transfer of n-butane from an aqueous environment to liquid n-butane. The observed contribution was explained, in terms of the hydrophobic interaction of the isobutyl group with the antigen binding site of the antibody molecule. These results were also compared with other hapten-antibody systems.

Animals↗

PubMed1965

Fractionation of ribonucleic acids with phenol. IV. Chromatographic analysis of a rapidly labelled RNA fraction of the normal rat liver.

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Animals↗