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Biomedical subjects

J Tisnado

Publications and source records attributed to J Tisnado.

At least 55 records · Page 3Linked to original sources

Radiographic findings in the chest of patients following cardiac transplantation.

The postoperative chest radiographic findings in 38 patients undergoing orthotopic (37 patients) and heterotopic (1 patient) cardiac transplantation were evaluated. Findings were correlated with those of echocardiograms, sputum and blood cultures, and lung and heart biopsies. The radiographic manifestations in the chest of these patients are classified in the following three main categories: (1) Newly formed cardiac silhouette findings due to the transplanted heart itself, i.e., changes in size and shape of the new heart and pericardial effusion resulting from the placement of a smaller heart in a larger pericardial sac. (2) Infectious complications due to bacteria, fungal, and other opportunistic agents secondary to immunosuppressive therapy, and (3) Usual postoperative complications following thoracotomy and open-heart surgery.

Adolescent↗

Percutaneous unknotting of intravascular catheters and retrieval of catheter fragments.

During a 5-year period, percutaneous unknotting of knotted catheters or retrieval of intravascular catheter fragments was performed in 21 patients by various interventional radiologic techniques. Eight of nine knotted Swan-Ganz catheters were successfully released, whereas one required the assistance of a surgical cutdown under local anesthesia; 10 of 11 embolized catheter fragments in various locations were retrieved successfully. One failure occurred with complication of peripheral embolization in the lung. Four case reports are presented. The overall success rate was 95%.

Adolescent↗

Fibrodysplasia of the popliteal arteries.

Fibrodysplasia is a generalized arterial dysplasia of unknown etiology. We report a case involving both popliteal arteries. The patient presented with microemboli of the toes of both feet originating in the dysplastic popliteal arteries. The clinical significance of popliteal artery fibrodysplasia is briefly discussed.

Aged↗

Use of isosulfan blue for identification of lymphatic vessels: experimental and clinical evaluation.

Use of vital dyes for identification of lymphatic vessels before cannulation has heretofore not been approved by the Food and Drug Administration (FDA). The suitability of isosulfan blue, the 2,5 disulfonic acid isomer of Patent Blue, for this purpose was evaluated experimentally in the rat and clinically in 11 volunteers and 543 patients under an investigational new drug application. FDA approval for this drug has been obtained. Volunteers and patients received up to 15 mg of a 1% sterile, pyrogen-free solution per extremity (total dose of 0.4 mg/kg in the average patient). Excellent identification of lymphatic vessels was achieved in 100% of volunteers and in 97.4% of patients. In the other 2.6%, lymphatic vessels were not identified mainly due to congenital lymphatic vascular (Milroy) disease. Baseline blood chemistry in volunteers was not altered after administration of the dye. No adverse reactions were found in volunteers and minimal allergic reactions occurred in less than 1% of patients. Acute toxicity studies demonstrated an LD50 greater than 150 mg/kg in the rat. Isosulfan blue was excreted unchanged in the urine (7%) and feces. Comparable excretion was found in volunteers. Isosulfan blue is a safe and efficacious vital dye for lymphangiography.

Adult↗

Perforation and hemorrhage of a non-Meckelian ileal diverticulum: preoperative angiographic diagnosis.

A 54-year-old male with infective bacterial endocarditis experienced right lower quadrant pain and gastrointestinal hemorrhage. The clinical impression of hemorrhagic diverticulitis was supported by the preoperative angiographic findings of a collection of extravasated contrast material in the right lower quadrant of the abdomen originating from a branch of the ileocolic artery. Exploratory laparotomy and pathologic examination of the resected specimen confirmed an ileal diverticulum which had perforated and was the source of hemorrhage.

Angiography↗

Body computed tomography in the evaluation of pediatric malignancy.

Fifty-eight body CT scans were obtained in 33 children with malignant disease over a 2-year period at the Medical College of Virginia Hospitals. When compared with conventional radiography, excretory urography, nuclear medicine, and ultrasound, CT provided additional information in 26 patients (78%). In 17 patients CT was useful for monitoring response to surgery, radiation therapy, and/or chemotherapy.

Abdominal Neoplasms↗

Renal ablation with the Gianturco stainless steel coil for control of massive proteinuria.

We describe a patient with membranoproliferative glomerulonephritis, renal failure, hypoalbuminemia and massive proteinuria. Attempts to reduce the protein loss with corticosteroids, indomethacin and mercurial diuretics were unsuccessful. Renal artery occlusion via Gianturco stainless steel coils was accomplished with the sole major complication of an ileus, probably caused by narcotics given for analgesia. The coils provide a convenient means of terminating renal function without resort to nephrectomy.

Embolization, Therapeutic↗

Computed tomography in the evaluation of carcinoma of the ovary.

Over a 26 month period, 34 patients with histologically proven ovarian malignancy were studied by computed tomography (CT). In nine patients, CT was obtained for evaluation of a pelvic or abdominal mass. Computed tomography was diagnostic of ovarian malignancy in seven and indeterminate regarding the origin of the tumor in two patients. Ten patients were evaluated by CT in order to rule out recurrent ovarian neoplasm. Disease free intervals prior to CT ranged from 6 to 36 months with an average of 18 months. In eight surgically proven cases, CT was true positive for recurrent tumor in six patients, true negative in one, and false positive in one. In 20 patients, serial CT examinations were valuable in the objective assessment of measurable tumor response following chemotherapy and radiation therapy. A major limitation of CT was its inability to detect peritoneal and liver surface implants smaller than 2 cm in size.

Cystadenocarcinoma↗

Pulmonary arteriography in patients with hilar or mediastinal masses and lung scans suggesting pulmonary embolism.

Three patients with clinical features of pulmonary embolism were evaluated by chest roentgenograms, perfusion lung scanning, and pulmonary arteriography. All of them had hilar and/or mediastinal masses which were obvious in one patient, subtle in another, and not discernible in the third. The three patients had abnormalities on lung scans, including unilateral absence of perfusion in two and lobar absence of perfusion in one. The extent of the perfusion defects correlated poorly with the roentgenographically visible masses. Pulmonary arteriograms were abnormal but none showed evidence of pulmonary embolism. Lung scanning is often unreliable in establishing the diagnosis of pulmonary embolism in patients with hilar or mediastinal masses. Pulmonary arteriography may demonstrate the mass if it is vascular, or may show extrinsic compression upon the pulmonary vasculature. Lung scanning may be of value in localizing a mass not visible on chest roentgenogram in a patient suspected of harboring a bronchogenic carcinoma.

Adult↗

Recurrent carcinoma of the cervix: CT diagnosis.

Thirty-three patients with previously treated carcinoma of the cervix were evaluated with computed tomography (CT) for recurrent tumor. Recurrent carcinoma was confirmed in 29 patients and radiation sequelae were documented in four patients. CT diagnosis was true positive for recurrence in 82%, false negative in 6%, false positive in 6%, and equivocal in 6%. False-negative examinations were due to small, superficial, clinically detectable tumor foci in the vagina or perineum. False-positive and equivocal examinations were due to radiation changes in the true pelvis. CT was valuable in assessing central pelvic tumor recurrence, parametrial and sidewall tumor extension, pelvic and paraaortic lymphadenopathy, and the obstruction site of hydronephrosis. Since CT detected recurrent tumor in 27 of 29 patients (sensitivity 93%), it is a valuable noninvasive technique to screen patients with suspected recurrent tumor and to evaluate those with known recurrence for disease extent and subsequent therapy.

Adult↗

Computed tomography of the perineum.

The value of computed tomography (CT) in the assessment of pelvic malignancy is well established. However, the importance of scanning caudad to the symphysis pubis to include the perineum has not been emphasized. The CT anatomy of the perineum in the transverse, coronal, and sagittal planes planes in normal subjects and in cadaver specimens is reviewed, and experience in 22 patients with pelviperineal pathology is reported. Malignancies in 16 patients were of the cervix (seven), vulva (six), vagina (two), and a recurrent mesenchymoma (one). Six patients had abscesses; one of these had cellulitis and skin ulcers. CT clearly depicts the perineal anatomy and is the imaging method of choice for the evaluation of malignancies and abscesses originating from or extending into this anatomic space. failure to include the perineum in the CT scanning of the pelvis will result in underestimation of disease extent. Multiplanar CT display of pelviperineal anatomy has great potential application in clinical work when high resolution coronal and sagittal reconstruction of transverse scans becomes available.

Adult↗