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Biomedical subjects

J Tingleff

Publications and source records attributed to J Tingleff.

25 records · Page 2Linked to original sources
PubMed1994

Casual blood pressure in a general Danish population. Relation to age, sex, weight, height, diabetes, serum lipids and consumption of coffee, tobacco and alcohol.

A population survey was conducted on 3608 randomly selected Danes aged 30, 40, 50 and 60 years respectively. Of these, 3400 were not in medical treatment for arterial hypertension. The following parameters were investigated: sex, age, serum lipid levels (total cholesterol, HDL cholesterol, triglycerides), presence of diabetes mellitus, height, body mass index (BMI), and average daily consumption of coffee, tobacco and alcohol. Analysis with multiple linear regression showed that all variables with the exception of triglycerides, HDL cholesterol and height were significantly associated with systolic blood pressure. Likewise all factors except diabetes, triglycerides and height were significantly associated with diastolic blood pressure. Further analysis in which the effect of each parameter was corrected for by the effects of the remaining variables, demonstrated that apart from age and sex only BMI and high alcohol consumption were positively associated with differences in blood pressure greater than a few mmHg. However, the variation in both systolic and diastolic blood pressures was only partly accounted for by the parameters studied--in the covariates analysis R2 for systolic blood pressure was 0.28 and R2 for diastolic blood pressure was 0.30. In conclusion, this investigation demonstrated that blood pressure is relatively independent of other factors important in the development of cardiovascular disease. Of the above-mentioned factors with some influence on blood pressure only age, BMI and high alcohol consumption have potential clinical importance.

Adult↗
PubMed1994

The Ross operation in the treatment of native and prosthetic aortic valve endocarditis.

Bacterial endocarditis of the native or prosthetic aortic valve is associated with significant morbidity and mortality despite aggressive medical and surgical treatment, especially when invasion of perivalvular tissue occurs. The currently recommended treatment for these advanced infections, in addition to thorough debridement, is aortic valve or root replacement with a homograft, although it appears that equally good results can be achieved with prosthetic valved conduits. Enthusiasm for the use of the pulmonary autograft as described by Ross for the treatment of non-infective aortic valve disease is increasing, but use of the pulmonary autograft in the treatment of aortic valve endocarditis is uncommon. This paper describes successful use of the Ross operation as total root replacement in six young patients between 10 and 32 years of age with aortic valve endocarditis. Three of the patients had active endocarditis and five patients had advanced disease, i.e. endocarditis with perivalvular tissue invasion and destruction. Follow up extending to 18 months continues to show excellent results with no mortality and no re-infection. We conclude that the Ross operation as total root replacement may be the best procedure for young patients with aortic valve endocarditis. The pulmonary autograft appears to be technically particularly well-suited, has growth potential, excellent hemodynamics, and a low risk of re-infection, thrombosis, and embolic complications without anticoagulation. Based on the long term results of the Ross operation in non-infected patients, excellent long term results are expected in this group as well.

Adolescent↗
PubMed1993

[Transesophageal echocardiography and endocarditis].

In 49 patients (34 men and 15 women with an average age of 51 years, range 21-81 years) with a total of 51 episodes of suspected or already demonstrated endocarditis, the diagnostic and therapeutic value of transthoracic echocardiography (TTE) was compared with transoesophageal echocardiography (TEE). It was demonstrated by operation, autopsy, or the course of the condition, that endocarditis was present in 34 cases, while 17 patients did not have endocarditis. The correct diagnosis was established in 19 out 51 cases (37%) by TTE and in 44 (85%) cases by TEE (p < 0.05). The number of ambiguous investigation results fell significantly from 30 (58%) with TTE to seven with TEE. A total of 14 cases of cavity formation related to endocarditis, rupture of fistulae, or perivalvular leakage from prostheses occurred. Three (21%) of these complications were demonstrated by TTE while TEE demonstrated all 14. After examination with TEE, treatment of the patients was changed in 20 cases (39%). It is concluded that: 1) TEE can confirm or exclude the diagnosis of endocarditis with much greater certainty than TTE, 2) TEE more than halves the number of ambiguous results of investigation and 3) TEE multiplies recognition of complications of endocarditis. Even although the results from the cardiological/thoracic surgical centre cannot be transferred to the primary hospital just like that, the results of these and other investigations suggest that TEE should be carried out when TTE cannot confirm or exclude clinically suspected endocarditis with certainty.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

Surgical repair of a postendocarditis abscess cavity in the heart guided by intraoperative transoesophageal echocardiography.

A case of aortic prosthetic endocarditis is presented that was complicated by the formation of a cavity in the spatium between the aorta and the roof of the left atrium. At the primary operation this cavity had not been detected. During reoperation the surgeon localized the cavity in the cardioplegic heart, guided by transoesophageal echocardiography.

Aortic Valve↗
PubMed1991

[Transesophageal echocardiography. A new cardiologic examination method].

Transoesophageal echocardiography is a new diagnostic method which uses the oesophagus as an ultrasonic window to the heart and central vessels. The images obtained are often of supreme quality compared to those obtained by conventional transthoracic echocardiography, because the distance between the transducer and the heart is reduced. The equipment, the examination technique, and preliminary experience after 80 examinations are described. It is concluded that the technique is particularly informative in patients with endocarditis or mitral valve disease and that the transoesophageal approach has become essential for the diagnosis of prosthetic valve dysfunction. Furthermore, the technique allows visualization of the descending aorta, which is often impossible to image from the precordial window, and the technique has proved useful in the emergency diagnostic elucidation of aneurysm of the thoracic aorta. So far a limited number of formal investigations comparing the results of transoesophageal echocardiography with the results of reference methods have been performed, however, practical clinical experience is already sufficiently extensive to state that transoesophageal echocardiography has come to stay. Disregarding coronary angiography it seems probable that combined transthoracic and transoesophageal echocardiography with time will eliminate the need for cardiac catheterization and angiography.

Contraindications↗
PubMed1989

[Unnoticed loss of renal function during treatment with angiotensin I converting enzyme inhibitor. A new risk in patients with unrecognized unilateral stenosis of the renal artery].

When patients with functional unilateral renal artery stenosis are treated with an angiotensin I converting enzyme inhibitor (ACE-inhibitor) a risk is present for loss of the function of the affected kidney without clinical symptoms. Renal function should therefore be controlled in these patients before and after initiation of the treatment. Even a slight increase in serum creatinine must be followed by reassessment of the treatment and investigation for renocascular hypertension must be considered.

Acute Kidney Injury↗