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Biomedical subjects

J Timmermans

Publications and source records attributed to J Timmermans.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Comparative evaluation of the gastric transit of floating and non-floating matrix dosage forms].

The gastric transit of floating and non-floating matrix dosage forms has been studied by means of a gamma scintigraphic imaging technique. Results indicate that, on the one hand, buoyancy and non-buoyancy of the forms lead to distinct intragastric behaviours and that, on the other hand, a selective gastric retention is operated in function of the diametral size of the matrix. Depending on the subject posture, standing or supine, the gastric residence period of the form is hence determined either by its buoyancy or by its size. As sustained drug delivery systems, the floating dosage forms globally offer several advantages which might be worth taking into account.

Administration, Oral↗
PubMed1983

Dysplasia epiphysealis capitis femoris? A longitudinal observation.

From the age of 22 months, a boy with bilateral dysplasia of the femoral heads has been followed clinically and radiologically for over seven years. Initial ascertainment came through his mild but persistent waddling gait. The patient is of small stature with normal linear growth parallel to the third percentile. Hypothyroidism was ruled out. Fixed traction applied at 5 6/12 years for almost 3 months promptly relieved the one episode of hip pain but did not alter the favorable natural course. The hip dysplasia in this proband may differ from the type of dysplasia epiphysealis capitis femoris originally defined by Meyer. As has been recognized by others, the latter probably represents several related disorders instead of only a single nosological entity. Considerations on differential diagnosis, prognosis, and management are offered.

Bone Diseases, Developmental↗
PubMed1983

Familial infantile cortical hyperostosis.

Infantile cortical hyperostosis occurred in three generations of a family affecting eight different members. As confirmed in this family, Caffey disease is an autosomal dominant disorder of unknown etiology, with incomplete penetrance and variable expression.

Female↗
PubMed1979

Ring chromosome 15 syndrome.

Two new cases of ring chromosome 15 are reported. A review of the nine cases described in the literature shows that ring chromosomes 15 are associated with a rather uniform phenotype characterized by slight to moderate mental retardation, marked pre- and postnatal growth failure, triangular face, and short hands and feet.

Abnormalities, Multiple↗
PubMed1978

Defective neutrophil chemotaxis and raised serum ige levels in a child with recurrent bacterial infections and eczema. Influence of levamisole.

A 5 1/2-year-old girl, with a life-long history of recurrent staphylococcal infections and eczematous dermatitis had a defect in polymorphonuclear leucocyte chemotaxis and phagocytosis in autologous serum, a high serum IgE level, and a disturbed T cell function. Levamisole improved all the immunological abnormalities and there was a dramatic clinical improvement. Discontinuation of therapy with levamisole resulted in gradual deterioration.

Chemotaxis, Leukocyte↗
PubMed1975

Dominant mesomelic dwarfism of the hypoplastic tibia, radius type.

A new type of mesomelic dwarfism in two male siblings and their father is presented. The responsible mutant gene manifests itself phenotypically as a severe dysostosis of the tibia with shortening, bowing and pseudarthrosis and as a mild dysostosis of the radius. The fibulae and ulnae are secondarily affected, but the rest of the skeleton is normal. The disorder has an autosomal dominant mode of inheritance. It can be differentiated rather easily from the already known forms of mesomelic dwarfism.

Chromosome Aberrations↗
PubMedDate not supplied

[Mediastinoscopy].

Explore the source record for details and available documents.

Endoscopy↗