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Biomedical subjects

J Tignol

Publications and source records attributed to J Tignol.

At least 19 recordsLinked to original sources
PubMed1992

Long-term use of tianeptine in 380 depressed patients.

Tianeptine is a new tricyclic compound whose principal action is to increase the reuptake of serotonin. In a multicentre trial in which 380 depressed patients were treated for one year, tianeptine produced a significant reduction in the MADRS scores from day 14, with a sustained reduction maintained for up to 12 months; other measures of efficacy (HRSA, HSCL, and CGI) also reflected the improvement. Only 11% of patients withdrew because of recurrence of depression and 2% because of side-effects, which were mainly drowsiness, irritability, and gastrointestinal disturbance. Apart from a minor reduction in heart rate, unaccompanied by any conduction changes, no clinically relevant changes in vital signs or laboratory tests were seen. Seven subjects who attempted suicide by tianeptine overdose had favourable outcomes, in spite of also taking other psychotropic drugs or alcohol. No evidence of tolerance or withdrawal symptoms was seen after treatment was stopped. These results suggest that tianeptine has the potential to provide safe antidepressant activity in both the acute and chronic phases of treatment.

Adolescent↗
PubMed1992

Paroxetine in the treatment of melancholia and severe depression.

Meta-analyses of the worldwide paroxetine database assessed the efficacy of this compound in the treatment of both DSM-III defined melancholia and hospitalised patients with severe depression (HAMD > or = 25). The analysis for melancholia included 178 paroxetine treated patients and 66 patients treated with placebo. Paroxetine was significantly superior to placebo in the treatment of melancholia and a clear dose-response relationship was established. The meta-analysis for severely depressed hospitalised patients included 109 paroxetine treated patients and 107 patients treated with a tricyclic/tetracyclic control. Paroxetine and active controls showed comparable efficacy in the treatment of severely depressed hospitalised patients.

Adult↗
PubMed1990

Transcutaneous electrical stimulation with Limoge current potentiates morphine analgesia and attenuates opiate abstinence syndrome.

Transcutaneous electrostimulation is a somewhat controversial technique used in the management of the opiate withdrawal syndrome. We report an animal study of a particular transcutaneous electrostimulation called transcutaneous cranial electrostimulation, based on a technique used for many years on heroin addicts for the rapid severance of their addiction, which has been validated in a clinical setting by a double-blind trial. This technique involves the application of an intermittent high-frequency current (Limoge's current). Our experimental data show that this transcutaneous cranial electrostimulation increases morphine analgesia by threefold on the tail flick latency measure and produces a 48% attenuation of the abstinence syndrome observed after abrupt cessation of morphine administration. These results were obtained using a double-blind paradigm.

Animals↗
PubMed1989

[Sexual dysfunction in males in long-term hemodialysis].

A quick survey of the literature and the author's own observations in 93 males in dialysis enable them to define the model of sexual dysfunction affecting this kind of patients. Psychological, organic and iatrogenic factors are often linked to create complex troubles, often minimized by the patients themselves. It is still difficult to know whether the important biological - in particular hormonal - disorders necessarily induce impotence. Big efforts in the research and the management of these patients are needed to help them in improving their quality of life.

Adaptation, Physiological↗
PubMed1980

Spontaneous dyskinesias vs. neuroleptic-induced dyskinesias in 270 elderly subjects.

A comparative study of spontaneous dyskinesias and neuroleptic-induced dyskinesias was made in 270 elderly subjects of a retirement home in France. Females were found to have twice the incidence of dyskinesias (27%) than did males (12%) (p = .04). In addition, 18% of the patients who had not received neuroleptics had dyskinesias; however, 42% of those who had received neuroleptics had dyskinesias. This difference is significant at the p = .0001 level. These results are discussed in terms of the general phenomena of central nervous system degeneration in the elderly.

Aged↗
PubMed1980

[Spontaneous dyskinesia in the elderly and tardive dyskinesia of neuroleptics. A survey among 270 patients (author's transl)].

Spontaneous dyskinesia among institutionalized elderly are much more frequent than previously thought. On 270 patients of a retirement home 63 (23.3%) exhibit a buccolinguofacial dyskinesia. Average age is 81.8. Frequency is twice higher among women (26.7%) than in men (15.2%), and twice and half higher if patients were given neuroleptics (42.4% versus 18%).

Aged↗