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Biomedical subjects

J Thompson

Publications and source records attributed to J Thompson.

At least 865 records · Page 48Linked to original sources

Continuous quality improvement efforts decrease postoperative ileus rates.

This article describes a continuous quality improvement team's efforts to reduce the number of patients at risk for developing a postoperative ileus. This study was limited to patients who underwent a surgical procedure that did not involve the bowel. Patients who developed an ileus after the surgical procedure (study group) were compared with patients who did not develop an ileus after the same procedure (control group). Principal factors associated with a postoperative ileus included a low serum albumin level, excessive use of narcotics, and a history of a previous gastrointestinal condition. Practice changes were made as a result of these findings. A follow-up chart review revealed a decrease in the postoperative ileus rate.

Analgesics, Opioid↗

Effects of interleukin-4 or stem cell factor on mast cell mediator release and cytokine gene expression.

We have investigated the capacity of interleukin (IL)-4 or stem cell factor (SCF) to induce direct mediator release from rodent peritoneal mast cells, and also to induce or regulate cytokine gene expression in the human HMC-1 mast cell line. SCF, but not IL-4, induced low levels of serotonin release from mouse or rat peritoneal mast cells; rat mast cells acquired enhanced responsiveness to SCF during culture. IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several genes, including the cytokines IL-3, IL-4, granulocyte/macrophage-colony-stimulating factor, IL-8 and the receptor for IL-6 in the human HMC-1 mast cell line.

Animals↗

Telephone-guided placement and removal of nicotine monitors for the assessment of passive exposure to environmental tobacco smoke.

The aim of this study was to determine the feasibility of telephone-guided placement of nicotine air sampling monitors in homes of women with infants. A monitor was mailed to homes in which the mother, her partner, or both were smokers, and a research assistant telephoned the woman and guided her through proper placement of the monitor according to a standard protocol. To assess the success of the guided placement, research assistants visited the homes of 50 women at the end of the two-week air-sampling period. The placement was determined to be correct if the monitor was positioned at least 1 ft from windows, more than 1 ft from the nearest corner of the room, and more than 2 ft from ashtrays. We had a 94% success rate for monitor placement in our study population, and our cost assessment showed that guided placement and removal cost approximately one-tenth the amount of methods requiring research assistants to conduct placements onsite. These results suggest that telephone-guided placement of monitors is an acceptable, inexpensive alternative to onsite placement by research assistants.

Costs and Cost Analysis↗

Annual report on access to and utilization of health care for children and youth in the United States--2000.

OBJECTIVE: This report provides an update on insurance coverage, use of health care services, and health expenditures for children and youth in the United States. In addition, the report provides information on variation in hospitalizations for children from a new 22-state hospital discharge data source. METHODS: The data on insurance coverage, utilization, and expenditures come from the Medical Expenditure Panel Survey. The data on hospitalizations come from the Database for Pediatric Studies, which is part of the Healthcare Cost and Utilization Project. Both data sets have been prepared by the Agency for Healthcare Research and Quality. RESULTS: Few changes in insurance coverage occurred between 1996 and 1998. About two thirds of American children are covered by private insurance and 19% by public sources; the remaining 15% are uninsured. Of the 71.5% of children who have at least 1 doctor's office visit, the average number of visits was 3.9, but this ranged from 2.7 among the uninsured to 4.2 for those with private insurance. Slightly more than half of children had a prescription, and these averaged 5.4 prescriptions. The majority of children (85%) incur medical expenditures, averaging $1019 for children with any expenditure. Private health insurance was by far the largest payer of medical care expenses for children, even more so than among the general population. However, nearly 21% of expenditures for children's health care were paid out of pocket by children's families. The data also show substantial differences in average length of hospitalization across states, ranging from 2.7 to 4.0 days, and rates of hospital admission through the emergency department, which vary across states from 9% to 23%. Injuries are a major reason for hospitalization, accounting for 1 in 6 hospital stays among 10- to 14-year-olds. In the 10-17 age group, 1 in 7 hospital stays are due to mental disorders. Among 15- to 17-year-olds, more than one third of all hospital stays are related to childbirth and pregnancy. CONCLUSION: Children's use of health care services varies considerably by what type of health insurance coverage they have. Expenditures for children entail a substantial out-of-pocket component, which may be quite large for children with major health problems and which may represent a significant burden on lower-income families. Substantial variation in hospitalization exits across states.

Adolescent↗

Central nervous system monoamine neurotransmitter turnover in primary and obesity-related human hypertension.

Recent experiments in laboratory animals have challenged the conventional view that the dominant effect of CNS noradrenergic neurons in cardiovascular control is sympathetic nervous inhibition and blood pressure reduction, describing instead sympathetic activation. We have tested whether such a stimulant effect on sympathetic outflow is also evident in human hypertension. CNS norepinephrine turnover was estimated from the combined overflow of norepinephrine, MHPG and DHPG into the internal jugular veins. Cerebral blood flow scans allowed differentiation between cortical and subcortical jugular venous drainage. In patients with pure autonomic failure, jugular overflow of norepinephrine and metabolites was not reduced, indicating brain neurons and not cerebrovascular sympathetics was the source. In healthy men, CNS norepinephrine turnover and muscle sympathetic nerve activity were directly related (p < 0.02). Administration of the ganglion blocker, trimethaphan, caused a compensatory five-fold increase in jugular overflow of MHPG. Conversely, intravenous clonidine reduced CNS norepinephrine turnover by approximately 50%, this possibly representing a mechanism of drug action. In cardiac failure patients, sympathetic nervous activation was associated with a trebling of CNS norepinephrine turnover (p < 0.01). In untreated patients with essential hypertension, the sympathetic activation present was associated with 250% higher CNS norepinephrine turnover (p < 0.01), but in subcortical brain regions only. A close and direct relation exists between brain norepinephrine turnover and human sympathetic nervous activity. CNS release of norepinephrine, presumably in the forebrain where noradrenergic neurons are sympathoexcitatory and pressor, mediates increased sympathetic nerve firing in patients with essential hypertension.

Animals↗

The significance of urine testing.

The examination of urine to discover the nature, causes and prognoses of diseases was one of the earliest procedures to be adopted by physicians. Today, urine testing remains an important aid in diagnosing and monitoring disease and treatment, and in helping to provide clues to a patient's health and wellbeing. June Thompson discusses the value of this nursing procedure.

Humans↗

Irritable bowel syndrome.

June Thompson looks at causes, incidence and symptoms of irritable bowel syndrome, the most common disorder of the intestines, which affects one in seven of the population.

Colonic Diseases, Functional↗

Effects of paired and unpaired eye-blink conditioning on Purkinje cell morphology.

This experiment addressed (1) the importance of conjunctive stimulus presentation for morphological plasticity of cerebellar Purkinje cells and inhibitory interneurons and (2) whether plasticity is restricted to the spiny branches of Purkinje cells, which receive parallel fiber input. These issues were investigated in naive rabbits and in rabbits that received paired or unpaired presentations of the conditioned stimulus (CS) and unconditioned stimulus (US). To direct CS input to the cerebellar cortex, pontine stimulation served as the CS. Air puffs to the cornea served as the US. Paired condition rabbits received pontine stimulation for 350 msec paired with a coterminating 100-msec air puff. Unpaired condition rabbits received the same stimuli in a pseudorandom order at 1- to 32-sec intervals. Rabbits were trained for a mean of 12 days. Naive rabbits received no treatment. In Golgi-stained Purkinje neurons in lobule HVI, total dendritic length, main branch length, total spiny branch length, and number of spiny branch arbors were all greater in the naive group than in the paired and unpaired groups, which did not differ. No differences were found between the hemispheres ipsilateral and contralateral to the trained eye. The dendritic length and number of branches for inhibitory interneurons did not differ across groups. The Purkinje cell morphological changes detected with these methods do not appear to be uniquely related to the conjunctive activation of the CS and US in the paired condition.

Animals↗

Nurses' use of patient notes to chart bowel care management for the palliative care patient.

Little is known about nurses' knowledge base and practice in the provision of Bowel Care Management (BCM). Recently, a study designed to investigate both factors was conducted in two hospices, one in New South Wales and the other in South Australia. Twenty-four nurses and 100 palliative care patients participated in the study. The audit of patients' medical records, one of several research methods used in the study, will be discussed here. The research identified that in all but two cases, patients' information about their BCM practices used in the home environment was not documented on their admission to the hospice. Further, the considerable number of charts used in each hospice to record BCM generally asked for information related to bowel function and the use of pharmaceutical preparations, to the exclusion of other methods of management.

Colonic Diseases, Functional↗

Air movement visualization in the workplace: current methods and new approaches.

Airflow visualization in the workplace to assess containment, ventilation, or general air movements is often carried out using smoke tracers. The most prevalent method uses a disposable smoke tube that generates a plume of concentrated sulfuric acid fume. However, use of the smoke tube exposes occupational hygienists to the risk of sulfuric acid exposure through inhalation or dermal contact, as well as injury from sharps. Following concern over the potential health hazard associated with smoke tube usage, alternative flow visualization methods and technologies have been reviewed. Methods of generating smoke or bubbles other than using smoke tubes suitable for visualizing air movements include heated element smoke generators, combustion generators, generation of metallic chlorides and ammonium chloride, generation of neutral density bubbles, and water fog generation. Some of these methods are applicable in specific workplace situations. However, there is no commercially available smoke or bubble generator currently available that matches the smoke tube for cost effectiveness, ease of use, and wide applicability, while also reducing the potential health risks associated with smoke tube usage. Despite this, certain technologies, in particular water/glycerol smoke generation using heated element generators, have the potential to be developed into viable alternatives to the smoke tube. Thus, with further development, an air movement visualization method that poses a significantly lower health hazard than the smoke tube is feasible.

Aerosols↗

Quality product.

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Beds↗

Mixed blessings.

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Community Health Nursing↗

School for health.

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Health Priorities↗

Covering baby.

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Cystic Fibrosis↗