[The contribution of Gilbert Breschet to the study of rabies and glanders].
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Biomedical subjects
Publications and source records attributed to J Theodorides.
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Born in 1820 Joseph-Desire Tholozan joined in 1841 as "chirurgien sous-aide auxiliaire" the French military Health Service, being still a medical student in Marseille where the School of Medicine was directed by his uncle F. Cauviere. He was later appointed at the hospital of Bastia, obtained his M.D. (Paris 1843), went back to Marseille and later to Metz (1845) and Paris, at the Val-de-Grace (1846-47). He returned there as assistant physician (1851) and later as professor "agrege" of Medicine (1852), his agregation thesis devoted to hematology being presided by Andral. Tholozan later participated to the Crimean war (1854-55) during which he performed important observations on infectious diseases (cholera, dysentery, typhus, typhoid fever) or deficiency ones (scurvy, acrodynia). An unpublished report given here deals with a probable epidemic of murine typhus occurring in soldiers returning from Crimea on an American ship which had been used to transport horses. Promoted first class major physician (1857) Tholozan was chosen in 1858 by the French ministry of Foreign Affairs to become the physician of the Shah of Persia, Nasreddin Shah. In this country where he remained until his death (1897) he will have a threefold activity as organizer of the medical teaching, epidemiologist (of plague and cholera) and as a surgeon. Principal first class physician (the equivalent of Physician-Colonel) in 1868, he was definitely dismissed from the Army in 1880.
Tholozan arrived in Persia in 1858 and remained there until his death in 1897. Personal physician of Nasreddin Shah with the title of hakim bachi, he was also appointed director of the Medical School of Teheran founded in 1850. He trained many Persian physicians and wrote medical treatises printed in persian. In 1866 he married in Teheran a widow of greco-italian origin from whom he had a daughter, Elise, who will have many descendants. Besides his important monographs on epidemic diseases (plague, cholera, etc.) Tholozan wrote in 1869 a "Rapport a S.M. le Shah sur l'etat de l'hygiene en Perse". He accompanied the Shah during his three voyages in Europe (1873, 1878, 1889) and stayed for his health three years in France after the last one, being replaced by Dr. Feuvrier as physician of the Shah. The friendly relations between Tholozan and the French archeologists Marcel and Jane Dieulafoy for whom he obtained from the Shah the permission to undertake diggings at Susa are recalled with the help of unpublished documents.
Malta fever (brucellosis) is an infectious disease of cattle (chiefly goats) which can infect man. Although the disease is not limited to Malta, occurring also in other mediterranean countries as well as in Asia and America, it was originally described in 1863 in Malta where the responsible bacteria (Brucella melitensis) was discovered in 1887 by D. Bruce. Ten years later Wright & Smith (1897) showed that the agglutination test originally established for typhoidic patients could be used for the diagnosis of Malta fever. Finally the conclusions of the Commission for the investigation of Mediterranean fever (1905-1907) are briefly recalled.
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In a flock of 20 ewes naturally infected with those parasites of sheep most common in Greece, and kept indoors during the whole trial, oxfendazole at the dose rate of approximately 2.9 and 2.8 mg/kg body-weight was tested as a 4 g bolus containing 112 mg active ingredient and a 2.265% suspension. The evaluation of its efficacy was based on the necropsy findings which were also supported by faecal egg counts. No differences in efficacy were noticed between the two formulations of the drug. Both bolus and suspension proved to be 100% effective against Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, T. colubriformis and Chabertia ovina. The efficacy against Cooperia oncophora, Nematodirus spathiger, Bunostomum trigonocephalum, Oesophagostomum columbianum and Moniezia expansa could not be evaluated, because these species, though not found in any of the treated animals, were found in fewer than three controls.
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Malaria rarely mentioned in literary works has been dealt with by the two writers, both physicians, studied here. Louis-Ferdinand Destouches (1894-1961) alias Celine, studied medicine in Rennes and Paris from 1921 to 1924. He had been previously engaged by the Rockefeller Foundation to lecture on tuberculosis in Brittany. He later worked for the Commission of Hygiene of the League of Nations in Geneva and took part in 1925 to a long voyage in America (Cuba, United States) and Italy where malaria was still occurring. In 1926 he published a book: La quinine en therapeutique and participated to another voyage in West Africa where he contracted malaria. Numerous hints to this disease inspired to Celine by his first trip to Africa (Cameroun) in 1916-17 are found in Voyage au bout de la nuit (1932). Carlo Levi (1902-1975) studied medicine in Torino from 1919 to 1924. Painter and writer he wrote there his masterpiece: Christ has stopped in Eboli (1945). Malaria which then decimated a very poor population of peasants abandoned to themselves represents the background of the book and it is as a competent and human physician that C. Levi gained the friendship of the inhabitants of this remote and inhospitable province.