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Biomedical subjects

J Tenczer

Publications and source records attributed to J Tenczer.

At least 73 records · Page 4Linked to original sources
PubMed1985

Metabolism of benzydamine.

After an oral dose of 50 mg benzydamine to three volunteers, urinary metabolites were identified by mass spectrometric techniques. 50-65% of the dose was excreted unchanged with the urine. The main metabolic pathways were elimination of the dimethylaminopropyl group, elimination of the benzyl group, desmethylation, N-oxidation, and hydroxylation of the benzene ring. Didesmethylbenzydamine and hydroxybenzydamine were excreted in form of their corresponding glucuronides.

Benzydamine↗
PubMed1985

Metabolism of propallylonal.

Urinary metabolism of 5-beta-bromoallyl-5-isopropylbarbituric acid (propallylonal, Noctal), was studied in humans after an oral dose of 400 mg. About 25% of the dose was eliminated via kidneys within 48 h. Besides the unchanged drug, six metabolites could be detected. The main metabolic pathway is the hydrolysis of the beta-bromoallyl side chain to an acetonyl function (approximately 15%). The acetonyl function is subsequently reduced to the corresponding alcohol. Loss of water leads to aprobarbital which is partially oxidized to aprobarbital epoxide. Two further metabolites are formed by partial and complete oxidative degradation of the beta-bromoallyl side chain. In contrast to previously published results, no N-methylpropyllalonal could be detected. The plasma protein binding was determined by ultrafiltration (63%). Analysis of propallylonal in plasma and whole blood gave evidence for equal distribution between plasma and erythrocytes.

Barbiturates↗
PubMed1984

Demonstration of reentry within the right bundle branch in man.

Reentry within the right bundle branch which, to our knowledge is a hitherto undescribed mechanism of His-Purkinje reentry in man, was elicited during programmed right ventricular stimulation. Electrophysiologic analysis excluded atrioventricular nodal reentry. His bundle reentry, reentry involving both bundle branches, and intraventricular micro-reentry.

Bundle of His↗
PubMed1984

Tiaprofenic acid overdose.

After ingestion of 2000 mg tiaprofenic acid (Surgam), a 14-year-old girl was admitted to the clinic. The ingested dose was tolerated without signs of systemic intoxication. Tiaprofenic acid, its metabolites, and products of chemical decomposition were identified by gas chromatography/mass spectrometry in the urine sample of the patient. Additionally, a previously unknown decomposition product of a metabolite was detected. For quantitation of the drug in plasma, a rapid and sensitive high-performance liquid chromatography assay was established.

Adolescent↗
PubMed1982

Concealed re-entry in the human heart.

The mechanism and electrophysiologic manifestations of concealed re-entry were studied in human electrocardiograms and intracardiac recordings. Previously described patterns of concealed re-entry were documented in 49 patients. In seven cases concealed re-entry was involved in the genesis of Wenckebach periodicity and alternating Wenckebach periodicity in the AV node, and "reversed" Wenckebach periods in the His-Purkinje system. These manifestations of concealed re-entry were not described so far. In five cases re-entry was apparently concealed. Complete (but hidden) circus movement of the supraventricular impulses in these patients were detected by intracardiac recordings and by analysing the effects of echo beats on timing of the subsequent sinus beats. Concealed re-entry of the cardiac impulse is a well-documented electrophysiologic event which explains many common and peculiar manifestations of impulse formation and impulse conduction in the human heart.

Arrhythmias, Cardiac↗
PubMed1981

Acute poisoning with pine oil - metabolism of monoterpenes.

A patient attempting suicide ingested 400-500 ml pine oil and was admitted to the clinic. Since more than the lethal dose had been ingested hemoperfusions with activated charcoal and amberlite and a hemodialysis were performed. The composition of the ingested pine oil was determined by gaschromatography/mass spectrometry. Four monoterpenes were identified: 57% alpha-pinene, 8% beta-pinene, 26% carene, 6% limonene and 3% other hydrocarbons. The blood and urine monoterpene concentrations were continuously monitored. The data suggest that monoterpenes are poorly resorbed in the gastrointestinal tract. The resorbed portion of the hydrocarbons cumulates in the lipophilic body compartments and is slowly metabolized and then excreted by the kidneys. The main metabolic pathways are hydratation, hydroxylation, rearrangement, and acetylation. Five metabolites were identified.

Bicyclic Monoterpenes↗
PubMed1980

Atrial reentry in chronic repetitive supraventricular tachycardia.

Atrial reentrance as a mechanism of the tachycardia was demonstrated in a 28-year-old patient suffering from chronic repetitive supraventricular tachycardia. Criteria for diagnosis included the following: (1) Repetitive supraventricular tachycardia was induced and terminated by properly timed atrial extrastimuli. (2) Return cycles of all atrial extrastimuli not abolishing the tachycardia were fully compensatory. (3) A-H prolongation was not a prerequisite to induce the tachycardia. (4) The contours of P and A waves during tachycardia differed from those in sinus rhythm, but atrial activation remained antegrade. (5) A concealed anomalous pathway could not be proved.

Adult↗