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J Tayot

Publications and source records attributed to J Tayot.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Sarcoidosis simulating a pulmonary veno-occlusive disease].

We report the case of a man of 43 years old presenting with sarcoidosis which produced pulmonary hypertension and respiratory failure without radiological evidence of interstitial fibrosis. In spite of treatment with steroids and corticosteroids (1 mg/kg) there was progression over 2 1/2 years to respiratory failure and irreversible right heart failure and the death of the patient. At autopsy the pulmonary veins were obliterated by non caseating granulomas and there were minimal fibrotic parenchymal lesions. To our knowledge this is only the second case of sarcoidosis resulting in a veno occlusive pulmonary disorder.

Adult↗
PubMed1990

Cytomegalovirus encephalopathy in an infant with congenital acquired immuno-deficiency syndrome.

A female infant born pre-term to a HIV seropositive mother presented at birth with seropositivity for HIV and CMV viruria. At five months of age she developed an AIDS-related complex. Six months later she died from rapidly progressive diffuse encephalopathy. Post mortem examination revealed generalized CMV infection. Neuropathological examination showed a nodular encephalitis with occasional cytomegalic cells containing characteristic CMV inclusion bodies. There was no evidence of HIV encephalitis; immunostaining for HIV antigen (gp 41) was negative. Opportunistic infections in infants with congenital AIDS are the exception. To our knowledge, only one case of CMV encephalitis in an infant with congenital AIDS has been reported previously. In that case, as in the present one, a reactivation of a congenital CMV infection is likely.

AIDS-Related Complex↗
PubMed1990

[A case of primary osteosarcoma of the liver].

The authors report a case of primary osteosarcoma of the liver in a 75 year-old man with post hepatitic B cirrhosis. The hepatic tumor was discovered on ultrasound and computed tomography. Angiography showed a hypervascularized tumor. The patient died rapidly. Diagnosis of primary osteosarcoma of the liver was established through histopathological examination of post mortem specimens and was confirmed by immunohistochemical study. From this and two other previously reported cases the authors describe the different primary hepatic tumors mimicking osteosarcoma.

Aged↗
PubMed1989

[Endophthalmitis caused by Aspergillus (anatomo-clinical study of a case)].

The authors report a case of endogenous aspergillosis endophthalmitis. Ocular involvement was very important and not controlled by several vitrectomy and intra-vitreous Amphotericin B. Pathological examination revealed abscesses in the vitreous, choroid and retina. Diagnosis and treatment are discussed.

Aspergillosis↗
PubMed1987

Catecholamine synthesizing enzyme activity in brainstem areas from victims of sudden infant death syndrome.

In order to investigate whether central catecholaminergic neurons are altered in sudden infant death syndrome (SIDS), the activities of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were determined in nine brainstem areas from 19 victims of totally unexplained SIDS (tSIDS), 9 victims of partially unexplained SIDS (pSIDS) and 8 control infants. The distinction between tSIDS and pSIDS was made according to the results of the autopsy. They were totally negative for the tSIDS victims, while minor pathological alterations were found in pSIDS victims. In both tSIDS and pSIDS victims, the PNMT activity was significantly decreased in the medullary C2m and C21 areas and in the nucleus medullae oblongatae centralis. In the C21 area only DBH activity was decreased. Further, in the nucleus ambiguus PNMT activity was decreased in tSIDS, while DBH was lowered in pSIDS victims. No significant modifications were found in the areas from the dorso-lateral pons (locus coeruleus, Kolliker Fuse and parabrachialis nuclei). Thus, in the two groups of SIDS victims the capacity to synthesize adrenaline was decreased in some medullary areas. It is considered that these biochemical alterations are related to the abnormal central respiratory and arousal control, which is thought to be present in SIDS.

Brain Stem↗
PubMed1987

Evonymus europaeus agglutinin as a marker of endothelial cells in the human.

Vascular endothelial cells were marked with Evonymus europaeus agglutinin (EEA) in the major organs of 6 subjects to reveal the anatomical distribution of positive elements in the human after fixation in paraformaldehyde-lysine-periodate and embedding in paraffin. EEA may be used as a marker of human adult vascular endothelium in the same way as Ulex europaeus Agglutinin 1, revealing the same positive endothelial and epithelial territories. The intensity of labeling was constant in a given subject of the B blood group. In A or 0 individuals the cerebral endothelium showed a much lower reactivity than the cardiac endothelium. This lectin, equally active in higher mammals, offers the unique advantage of direct comparison between species.

Adult↗
PubMed1987

[Retrospective study of 25 sudden death in 25 infants hospitalized during the neonatal period].

During a 6 years period, 25 newborns admitted to a neonatal intensive care unit died suddenly in the first year of life. The risk of sudden death in this specific population is 5% and reaches 7.4% in the low birth weight population (less than or equal to 2,500 g). In 12 infants, the sudden death was partially explained; in 7 infants, the sudden death remained unexplained on the basis of clinical and necropsic findings; in 6 infants, the clinical data did not justify the sudden death but necropsies were not performed. A comparison with matched living control infants showed that there was a significant increase of minor malformations of the branchial arch system and that in the sudden infant death group, threatening premature labour was more frequent during the mothers' pregnancies.

Abnormalities, Multiple↗
PubMed1984

A critical comparison of the history of sudden-death infants and infants hospitalised for near-miss for SIDS.

To determine whether significant historical differences distinguish the near-miss for Sudden Infant Death from the infants who died of SIDS, we analysed the histories and clinical data from two groups of infants seen in our University Hospital and from collaborative research group. The data were obtained with the use of a standardised questionnaire and consultation of all available medical data. Sixty-five infants were identified as near-miss for SIDS after they had suffered a severe cardiorespiratory incident during sleep for which no cause could be found despite a complete medical examination. After an autopsy had failed to reveal a cause for the unexpected death 95 cases of SIDS were retained in the study. A series of 353 variables were collected from the parents, the gynaecologists, neonatologists and attending physicians. After statistical analysis, only 15 of the 353 items studied significantly differentiated between the two groups. A step-wise discriminant analysis performed on these items led to the identification of six independent variables: the time of the incident; the circumstances leading to the observation of the child; the child's sleep position; previous minor intestinal problems; the size of the family and the mother's coffee consumption. Most variables indicate that the near-miss infants were discovered and rescued earlier than the infants who died. No other historical information appeared significantly to differentiate between the two groups of infants. These data need confirmation from a prospective epidemiological survey.

Family Characteristics↗
PubMed1984

[Chemoinduced early precancerous colonic lesions in rats].

The aim of this study was to investigate the early histological changes during 1.2-dimethylhydrazine-induced carcinogenesis in the rat, and to search for a dose-response relationship. Thirty Wistar female rats received 1.2-methylhydrazine 15 mg/kg sc, weekly in a single injection, and were sacrificed after 1 to 9 weeks. The left portion of the colon was cut serially (300-350 sections per animal) and was then submitted to a routine histochemical study with 18 stains. Loss of mucous secretion and apical basophilia lesions were observed as early as the 2nd week. The rate of apical basophilia lesions, expressed in percentage of the total number of lesions, was significantly correlated with the total dose of carcinogen administered (p less than 0.001). The severity of the lesions (expressed as the logarithm of the total number of sections showing altered tubes) increased with the dose, first quickly, then more slowly afterwards. A significant correlation was observed between the site, as defined by the distance from the anal verge and the severity of the injuries (p less than 0.001) as they were located more proximally as the doses increased. The comparison of the results obtained from this series of animals sacrificed early and those from a former series with spontaneous survival, suggests that only 2 p. 100 of the apical basophilia lesions should develop macroscopic lesions (polyps or cancers). Hence, it is advisable to consider the chronology and the site of the sampling in order to interpret apparently divergent series.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1981

[Nervous system tumour proteins. G.F.A. and hyaluronectin (author's transl)].

G.F.A. (gliofibrillary acid protein) and hyaluronectin studied here are two antigens defined by the heteroantibodies which appear in the serum of the immunised animal. G.F.A. is associated with gliofilaments and is considered as an astrocyte marker, either normal or tumoral. Hyaluronectin, is found in the Ranvier nodes and at the periphery of neurones. It is not specific to the nervous system. It is found in all tissues and tumors, and in particular marks the intercellular spaces of gliomas, where it is associated with hyaluronic acid for which it has a great affinity. Serum estimation of these Proteins is being undertaken with the view to a clinical application.

Animals↗
PubMed1981

Preneoplastic changes in epithelium and mesenchyme in colon of rats treated with 1,2-dimethylhydrazine.

Twenty-eight rats were given weekly injections of 1,2-dimethylhydrazine (DMH) for periods of 1-10 weeks. The preneoplastic changes occurring in the descending colon were monitored by transmission electron microscopy. Marked uniformity was observed in the time period of lesion development in the colon induced by the carcinogen especially at the epithelialstromal junction in preneoplastic lesions. Little changes were observed after 3 weeks treatment with the DMH. The greatest changes occurred after 6 weeks treatment, resulting in epithelium and mesenchyme. It has been confirmed that 3 weeks treatment with DMH is subcarcinogenic, whereas 10 weeks treatment results in a high incidence of tumors. These findings are compatible with the hypothesis that a carcinogen may act by inducing alterations in a small number of enterocytes and that colonic tumors arise through stepwise evolutional changes in these cells.

1,2-Dimethylhydrazine↗
PubMed1980

Brain glycoprotein in tumours of the nervous system.

We studied various tumours of the nervous system by the immunofluorescence technique using an anti-brain specific alpha 2 glycoprotein antiserum (anti-NSA3 antiserum). We found the antigen in 24/27 astrocytomas and 4/4 oligodendrogliomas but in none of the 8 meningiomas tested. There was an identity between the astrocytoma/oligodendroglioma antigen and that of normal brain as shown by the immunoprecipitation technique. By the immunofluorescence technique using inhibition of the antiserum we demonstrated that the tumour antigen is devoid of some specific nervous system determinants present in normal brain.

Antigens, Neoplasm↗