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Biomedical subjects

J T Stringfield

Publications and source records attributed to J T Stringfield.

4 recordsLinked to original sources

Effect of CO2 induced pH changes on the response of isolated guinea pig tracheas to theophylline.

The effect of CO2 induced pH changes on the response of airway smooth muscle to theophylline was studied. Our data show that simulated respiratory acid-base disturbances (pH range 7.0 to 7.8) have no significant effect on the response of isolated guinea pig tracheal cylinders at basal tone to theophylline. On the other hand, tracheal cylinders precontracted with histamine showed a diminished sensitivity to theophylline at pH values above 7.40, and an enhanced sensitivity at pH values below 7.40.

Animals↗

The effect of tumor size and location on diagnosis by fiberoptic bronchoscopy.

Evaluation of data from fiberoptic bronchoscopic procedures revealed that for peripheral bronchogenic carcinomas, the diagnostic yield was influenced by the size of the lesion and its distance from the hilum. Failure to diagnose visible carcinomas was related to inability to obtain deep specimens for biopsy. Biopsy, brushing, and washing were complementary procedures in diagnosing bronchogenic carcinomas.

Biopsy↗

Pneumoperitoneum. A complication of mechanical ventilation.

Pneumoperitoneum occurred in three adults receiving mechanical ventilatory support. Since the presence of a perforated viscus could not be confirmed by combinations of clinical, surgical, or autopsy findings in any of these patients, it appears that the free abdominal air in these patients was a complication of the ventilatory therapy. It is possible that such a complication may be more common than is currently recognized and thus should be added to the differential diagnosis of pneumoperitoneum.

Adolescent↗