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Biomedical subjects

J T Robertson

Publications and source records attributed to J T Robertson.

At least 163 records · Page 9Linked to original sources
PubMed1979

The surgical management of extracranial and intracranial occlusive disease.

The role of surgery in preventing transient ischemic attacks and stroke in certain occlusive vascular lesions is well-established. This is well-established when carotid endarterectomy for carotid stenosis with transient ischemic attacks is used. The overall surgical results are best achieved by the frequent performance of the procedure and meticulous attention to technical as well as medical features of this group of patients at risk. Continuing medical care of these patients is essential. The long-term mortality rate is augmented by the high incidence of myocardial infarctions. Complete cardiac evaluation and good medical care, at the time the patient is initially treated, should subsequently minimize this event. Although the microvascular bypass procedures are technically feasible and associated with a low mortality rate, their exact role in the medical management of patients with intracranial occlusive lesions is unproven. However, the procedure offers great promise and an exciting future for neurosurgery in stroke therapy.

Arterial Occlusive Diseases↗
PubMed1979

Effect of nonsteroid anti-inflammatory drugs on subarachnoid hemorrhage in dogs.

The effects of two long-acting anti-inflammatory agents on behavioral changes and cerebral vasospasm were evaluated in a canine model of chronic subarachnoid hemorrhage (SAH). The agent with the longest half-life, sudoxicam, clearly reduced both the incidence and the magnitude of the vasopasm, and prevented the usual behavior changes caused by the stimulated SAH. The results obtained with the other agent, naproxen, suggested that it was better than the administration of saline. These agents were studied because of reports indicating that prostaglandins and thromboxane may play a role in the pathogenesis of the effects of SAH and because of nonsteroid anti-inflammatory agents exert pharmacological effects by reducing an excessive synthesis of these lipids. The findings suggest that some of these agents may afford an alternative treatment for the deterious consequences of SAH.

Animals↗
PubMed1979

Acoustic neuroma removal: a comparative study of translabyrinthine and suboccipital approaches.

A comparative study of the suboccipital and translabyrinthine approaches for acoustic neuroma removal in 91 cases using a otologic-neurosurgical team is presented. Fifty of these cases involved the suboccipital route using microsurgical techniques; the remaining cases involved the standard otologic routes. The same neurosurgeon participated in all 91 cases. Two otologists participated in the study. The results of our series of cases indicate that the suboccipital route is the procedure of choice for acoustic neuroma removal.

Ear, Inner↗
PubMed1978

The relationship between suture number and quality of anastomoses in microvascular procedures.

Microvascular end-to-side arterial anastomoses of vessels 1 to 2 mm in diameter were performed in 30 Sprague-Dawley rats. The animals studied differed in only one aspect, variance of suture number to complete the anastomosis. Angiographic and gross pathological evaluation of each animal demonstrated a direct correlation between quality of patency and number of sutures used to complete the anastomoses. A significant observation was made regarding unrecognized pathology in angiographically patent anastomosis.

Animals↗
PubMed1977

Combined approach surgery for removal of glomus jugulare tumors.

The ideal surgical treatment for glomus jugulare tumors is total removal. Efforts have been made periodically to accomplish this since shortly after this tumor was first identified in the early 1940's. This paper describes a method of removal using a combined approach through the neck and temporal bone, preceded by a course of preoperative irradiation therapy. The early results that have been obtained using this procedure in 10 patients are reported.

Adult↗
PubMed1977

Embolism to the central nervous system from cardiac myxoma. Report of two cases.

Two cases of left atrial myxoma are reviewed, both presenting as embolic phenomena. Neither patient gave a history compatible with pre-existent cardiac dysfunction. Sudden collapse and subsequent right hemiplegia resulted in one patient when an embolus lodged in the left middle cerebral artery. The second patient presented with headache and transient visual obscuration in the left eye. She showed evidence of embolism to the central retinal artery, and particulate matter could be seen within the retinal arterioles. Attention is drown to the fact that echocardiography now constitutes a simple, noninvasive, and highly reliable method of making this diagnosis. The propensity for embolic tumor fragments to grow and invade cerebral arterial walls is discussed along with its possible neurosurgical significance.

Adolescent↗
PubMed1976

Experimental evaluation of the spasmogenicity of dopamine on the basilar artery.

Arteriograms of the basilar artery reveal that dopamine given intracisternally to dogs can generate cerebral vasospasm. This finding supports a recent hypothesis of others that dopamine may play a role in the pathogenesis of vasospasm, especially since many substances are known which fail to produce such spasm. Compared to blood or prostaglandin E2, however, the spasm induced by dopamine was delayed in onset, less in incidence, and usually less intense. Possible explanations for such experimental differences are discussed.

Animals↗
PubMed1976

Spasmogenic qualities of prostaglandin F2alpha in the cat.

Available data indicate that the concentration of prostaglandin F2alpha required to produce arterial spasm in an experimental model is approximately a thousand-fold higher than the concentration that occurs under physiological conditions. The spasmogenic platelet factor which has been previously described is shown to be a substance other than prostaglandin F2alpha because of differences in susceptibility of the two substances to enzymatic digestion.

Animals↗