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Biomedical subjects

J T Mason

Publications and source records attributed to J T Mason.

52 records · Page 3Linked to original sources
PubMed1978

Segmental resection in the management of bladder carcinoma.

Segmental resection for bladder carcinoma was performed on 144 patients at our medical center between 1945 and 1971. Of these 144 cases 101 had sufficient documentation to provide meaningful data for a retrospective study. The 5-year survival rates for patients with invasive bladder carcinoma, expressed as a function of the stage of disease, were stage A--79 per cent, stage B1--80 per cent, stage B2--45 per cent and stage C--6 per cent. The combined survival rates for patients with stages O, A and B1 tumors and for those with B2 and C disease were 83 and 27 per cent, respectively. A significant observation was that of the patients with stages O, A and B1 disease only 7 per cent had a history of antecedent tumor. In contrast, 59 per cent of the patients with stage B2 and C disease had antecedent tumor.

Adult↗
PubMed1978

The prophylactic use--or misuse--of antibiotics in transurethral prostatectomy.

One hundred non-infected patients undergoing transurethral prostatectomy were randomized prospectively into a controlled study to determine the influence of a prophylactic aminoglycoside (kanamycin) on the clinical course. In the non-risk patient prophylactic kanamycin had no beneficial influence on the incidence of bacteriuria, fever or length of hospitalization. Its use was associated with the development of a resistant Pseudomonas super infection in 1 patient. Prophylactic kanamycin did not protect the patient with carcinoma of the prostate from bacteriuria. There was no identifiable advantage in the use of routine prophylactic kanamycin in the uninfected, non-risk patient who was undergoing elective transurethral prostatectomy.

Aged↗
PubMed1978

Geometric packing constraints in egg phosphatidylcholine vesicles.

This investigation presents a quantitative analysis of the asymmetric transmembrane lipid packing geometry in egg phosphatidylcholine vesicles. The analysis uses hydrodynamic and nuclear magnetic resonance data obtained for homogeneous egg phosphatidylcholine vesicles and demonstrates that the average area per lipid head group and effective length of the lipid are greater on the outer monolayer than on the inner monolayer of the egg phosphatidylcholine vesicle. Results also indicate that the bilayer of the egg phosphatidylcholine vesicles has an asymmetrical interface through its center.

Animals↗
PubMed1977

Random mucosal biopsies in the evaluation of patients with carcinoma of the bladder.

The management of patients with recurrent transitional cell carcinoma of the bladder has posed a constant dilemma to the practicing urologist. Previously, urine cytologies have been used and have been of value only in those instances in which they have been classified as diagnostic. Cytologies that reveal atypia or a high degree of suspicion have offered little help in the management of these patients. The current procedure of doing random mucosal biopsies using the cold cup biopsy forceps provides the pathologist with a sampling of the mucosa of the involved bladder so that a tissue diagnosis of sufficient magnitude, ranging from atypia to carcinoma in situ to frank carcinoma, may be established. This information may become valuable in determining alternate forms of management in these patients and may have a greater predictive value than customary urine cytology.

Aged↗
PubMed1977

Granulomatous prostatitis: confusion clinically with carcinoma of the prostate.

Non-specific granulomatous prostatitis is an inflammatory response of a foreign body type to extravasated prostatic fluid. Its significance is incident to its frequent confusion with carcinoma of the prostate. Noteworthy is the rapidity of onset of irritative and obstructive symptoms in a relatively younger age group than one generally sees in carcinoma of the prostate. Tissue diagnosis in those suspected of carcinoma of the prostate should be established by needle biopsy and conservative measures used for at least 4 weeks in the treatment of obstructive symptoms to allow the inflammatory response to subside before intervening surgically . Most patients frequently have associated benign prostatic hyperplasia with persistent obstructive symptoms and significant residual urine. Transurethral resection of the prostate has been performed in this study without postoperative complications.

Adult↗
PubMed1977

Total prostatectomy for stage B carcinoma of the prostate.

We reviewed 67 cases of total prostatectomy for localized stage B carcinoma of the prostate. There were no operative deaths. Significant morbidity was limited to the well known complications of impotence and incontinence. The over-all survival rates were 92 per cent for 5 years (42 of 46 cases), 79 per cent for 10 years (19 of 24) and 62 per cent for 15 years (8 of 13). Total prostatectomy continues to be the preferred method of therapy for this stage of prostatic cancer.

Adult↗
PubMed1976

Manifestations of renal cell carcinoma.

Patients with renal cell carcinoma often have no specific localizing symptoms or signs, and their presentation will often involve many organ systems. Since 40 per cent of these patients do not have genitourinary symptoms, care must be taken to avoid being misled by normal findings on urinalysis. More than 50 per cent of patients with renal cell carcinoma have vague symptoms suggesting a gastrointestinal origin; thus if primary gastrointestinal studies do not disclose a cause for these symptoms, excretory urography must be included as a screening procedure.

Adenocarcinoma↗
PubMed1976

Surgical management of renal lesions using in situ hypothermia and ischemia.

Many renal lesions that were once treated by nephrectomy now lend themselves to surgical correction. The value of in situ hypothermia and ischemia produced by occlusion of the renal artery is detailed. This technique has proved to be a simple, safe and effective surgical approach to the management of most difficult renal lesions.

Adenocarcinoma↗
PubMed1976

Experience with indwelling ureteral stent catheters.

A new indwelling ureteral stent to provide long-term ureteral drainage is described. This radiopaque stent is manufactured of non-reactive, non-collapsible tubing and is designed to resist downward expulsion and upward migration. Internal stent diversion offers advantages in managing patients whose ureters are obstructed by malignancy. 1) Endoscopic placement of the ureteral stent is associated with less morbidity and mortality than supravesical diversion. 2) Unilateral obstruction can be corrected at the time of diagnosis, thus ensuring that later supravesical diversion will not be necessary. 3) If time proves that the urinary diversion is no longer desirable in terms of quality of life, the stent can be removed.

Adult↗
PubMed1976

Observations on definitive cobalt 60 radiation for cure in bladder carcinoma: 15-year followup.

Radiation therapy will result in tumor disappearance in a select number of patients. However, it does not prevent local recurrence and, therefore, the patient continues at risk. Tumor recurrence was noted in more than half the patients in our series and more than 50 per cent of these patients experienced multiple recurrences. A functional bladder was maintained in nearly 60 per cent of the patients. Survival in 11 patients in category 1 with radiation therapy and subsequent non-ablative extirpative surgical procedures in 8 patients was equivalent to series treated by preoperative irradiation and cystectomy. In contrast the 14 patients in category 2 had a survival rate that was appreciably lower than that obtained with preoperative irradiation followed by cystectomy. There was a significantly increased morbidity associated with an open operation in the treatment of recurrence in the irradiated patient. We would advocate preoperative irradiation followed by cystectomy in the patients with high grade and high stage disease. The value of single versus adjuvant forms of therapy for patients with diffuse, rapidly recurring low grade and low stage disease would be determined best by a randomized prospective study. Evidence from this series suggests that irradiation improved over-all survival in this category.

Adult↗
PubMed1975

Renal pelvic tumors.

A study was made of 35 patients with tumors of the renal pelvis. Tumors were indipendently graded and staged by a newly proposed method. The method of staging correlated well with grading of renal pelvic tumors and bore a direct relationship with prognosis. The high incidence of associated urothelial tumors, especially on the involved side, mandated radical nephroureterectomy including a bladder cuff as the treatment of choice.

Adult↗