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Biomedical subjects

J T Done

Publications and source records attributed to J T Done.

At least 19 recordsLinked to original sources
PubMed1994

Rabies policy.

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Animals↗
PubMed1990

Liver warning.

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Food Contamination↗
PubMed1988

Porcine cytomegalovirus (PCMV) in early gestation.

Following intranasal exposure to PCMV at or within 48 h of coitus transplacental infection occurred in two groups of gilts. Five out of 22 embryos were infected in the first group but only 2 out of 63 in the second. A more rapid immune response as measured by circulating antibody was probably instrumental in abrogating infection in the second group. In the infected embryos the virus localized in leptomeningeal cells, hepatic sinusoidal cells, peritoneal macrophages, periosteal cells and occasional alveolar cells, but the placenta did not appear to be a primary site of viral replication.

Administration, Intranasal↗
PubMed1988

Superinfection with porcine cytomegalovirus initiating transplacental infection.

Four sows with circulating antibody were exposed to porcine cytomegalovirus. Virus was detected in 8 of 24 foetuses by immunofluorescence and/or virus isolation from 2 sows with low levels of antibody. In 6 of the infected foetuses, the virus was in capillary endothelium and macrophages of the lung, and was associated with interlobular oedema in 2 of these. Virus was also detected in the nasal mucosa, spleen and brain. The majority of the virus-positive foetuses were grossly normal.

Animals↗
PubMed1985

Border disease of sheep: spinal cord morphometry.

Semi-automated planimetry was used to determine cross-sectional areas of spinal grey and white matter by direct microscopy of paraffin sections of spinal cord from Border disease (BD) and normal lambs at segments C4, C8, T6 and L4. Spinal cord cross-sectional area was significantly reduced in cases of BD produced by either intramuscular or intranasal inoculation of ewes in the first half of pregnancy with Weybridge strains of BD virus. The reduction was apparent at all 4 levels and in both grey and white matter, though the white matter was the more severely affected. Spinal cord areas tended to be smaller in the progeny of ewes exposed earlier in gestation or to larger doses of virus, but these differences were not statistically significant.

Animals↗