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Biomedical subjects

J T Curnes

Publications and source records attributed to J T Curnes.

22 records · Page 2Linked to original sources
PubMedDate not supplied

MRI of corpus callosal syndromes.

Six patients, 6 to 13 years old, with corpus callosal abnormalities diagnosed by electroencephalography or CT were studied with a 0.15 T MR imager to determine the effectiveness of MRI in evaluating midline anomalies. Spin-echo images in the coronal, axial, and sagittal planes were obtained in two patients with Aicardi's syndrome and partial agenesis of the corpus callosum, in one patient with Dandy-Walker syndrome, and in two patients with septooptic dysplasia. Inversion recovery and spin-echo images were obtained in one patient with lipoma of the corpus callosum. Partial agenesis of the corpus callosum was seen in septooptic dysplasia, an association that has not been reported previously in the radiologic literature. Direct sagittal and coronal MRI provided better anatomic visualization of the brain and ventricles than did reformatted CT. T1-weighted images are sufficient to diagnose and delineate the extent of midline cerebral abnormalities. The unique capability of direct sagittal imaging makes MRI the best procedure for evaluating corpus callosal and other midline abnormalities.

Abnormalities, Multiple↗
PubMedDate not supplied

MR imaging of compact white matter pathways.

A prominent decreased signal intensity can be seen in many of the heavily myelinated, compact fiber pathways of the brain on T2-weighted spin-echo MR images (TR = 2500 msec, TE = 80 msec). These areas include the anterior commissure, internal capsule, optic tract and radiations, fornix, mammillothalamic tract, superior frontooccipital fasciculus, cingulum, corpus callosum, uncinate fasciculus, and superior longitudinal fasciculus. All these pathways could be identified in normal subjects 3 years old and older when 1.5-T axial and coronal images of 50 adults and 17 children were reviewed. Correlation of the in vivo and postmortem MR appearance of two human brains with Perls and Luxol fast blue stains indicates that the short T2 reflects heavy myelination and fiber density, not iron deposition. This is in contrast to the short T2 signal seen in the subcortical U fibers and deep nuclei of the brain that result from iron deposition. These pathways also differ from areas of brain iron accumulation in that (1) they may appear as areas of short T1 on partial-saturation or inversion-recovery pulse sequences and (2) they can be seen with regularity in all patients over 3 years of age. It is important to distinguish between the effect of the myelin sheath and the effect of brain iron on the T2 relaxation values seen in the normal brain since both result in shortened T2 relaxation. The importance of the role of these fiber tracts in disease processes and in modifying the spread of vasogenic edema and tumor needs further investigation.

Adolescent↗