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Biomedical subjects

J Szulc-Kuberska

Publications and source records attributed to J Szulc-Kuberska.

At least 19 recordsLinked to original sources
PubMed1988

Effect of bromocriptine and metoclopramide on serum prolactin levels in patients with amyotrophic lateral sclerosis.

Secretion of prolactin in nine patients with amyotrophic lateral sclerosis and in seven healthy men was investigated with the use of metoclopramide stimulation and bromocriptine inhibition tests. Blood serum prolactin concentration was determined in the basal state and 30, 60 and 120 minutes after oral administration of 10 mg metoclopramide or 2.5 mg bromocriptine. A period of 3 days intervened between testing each drug in the same individual. It was shown that basal prolactin levels in amyotrophic lateral sclerosis patients and the controls did not differ significantly, whereas in the metoclopramide stimulation test seven amyotrophic lateral sclerosis patients showed a very exaggerated response. The mean value of maximal prolactin increment was 1609.90% (SD 456) in comparison with the control group 638.3% (SD 89.7) (p less than 0.01). In the bromocriptine inhibition test the mean value of maximal prolactin percentage decrement was 50.4% (SD 6.1) in amyotrophic lateral sclerosis and 66.5% (SD 5.3) in the controls and this difference was statistically insignificant. These data suggest that exaggerated prolactin response to metoclopramide in amyotrophic lateral sclerosis may be a result of a decreased activity of central dopaminergic neurons.

Aged↗
PubMed1986

Epidermal growth factor in human cerebrospinal fluid: reduced levels in amyotrophic lateral sclerosis.

Epidermal growth factor (EGF), a mitogenic peptide, is widely distributed within the brain and endocrine cells of the gastro-intestinal tract. Using EGF radioreceptor assay, the EGF level was measured in lumbar cerebrospinal fluid from five patients with amyotrophic lateral sclerosis (ALS) and seven patients with intervertebral disc disease as a control group. The patients with ALS showed reduced EGF levels to 662.4 +/- 207 pg/ml as compared with controls 1013 +/- 182.8 pg/ml (P less than 0.02). These results indicate a possible EGF involvement in the pathogenesis of ALS.

Aged↗
PubMed1986

Reduced lumbar cerebrospinal fluid corticotropin releasing factor (CRF) levels in amyotrophic lateral sclerosis.

Corticotropin-releasing factor (CRF) is widely distributed within the brain and spinal cord and may have direct extrahypophysiotrophic effects, independent of its pituitary action. The CRF level was measured using, the RIA method in cerebrospinal fluid (CSF) from 5 patients with amyotrophic lateral sclerosis (ALS), and in CSF from 10 patients with discopathy, treated as a controlled group. The median values of CRF level in the patients with ALS was 27.5 pg/ml, and this value was significantly lower than in controls, 53.5 pg/ml (P less than 0.05). These results suggests that CRF may be related in the pathophysiology of ALS.

Aged↗
PubMed1980

[Transient blindness as a complication of vertebral angiography].

The authors report two cases of cortical blindness developing immediately after vertebral angiography. Visual disturbances were not associated with other symptoms art from nuchal rigidity in one patients. In both cases, cortical blindness regressed completely.

Adult↗
PubMed1979

Lithium therapy in cluster headache.

The authors used lithium carbonate in the treatment of 15 patients with cluster headache (chronic and episodice form). Disappearance of attacks was achieved in 5 patients (1 chronic and 4 episodic), significant improvement in 5 (4 chronic and 1 episodic) and in 4 cases (2 chronic and 2 episodic) treatment was ineffective.

Administration, Oral↗
PubMed1979

[Use of azathioprine in the treatment of chronic form of Guillain-Barré syndrome].

After discussing the clinical problems of the chronic form of Guillain-Barré syndrome the authors describe 8 own cases, treated with azathioprine 100 mg daily. In 3 cases drug tolerance was poor and the treatment had to be stopped. Considerable improvement was achieved in 3 cases, slight in 1, and no improvement in one patient.

Adult↗