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Biomedical subjects

J Szejtli

Publications and source records attributed to J Szejtli.

43 records · Page 3Linked to original sources
PubMed1980

Intestinal absorption of 14C-labelled beta-cyclodextrin in rats.

beta-Cyclodextrin and glucose labelled universally by 14C was administered orally to rats and blood radioactivity level was followed. In the case of glucose about 20% of the administered radioactivity, related to 10 ml blood was to be found and this appeared in the blood within 10 min following the oral administration. In the case of beta-cyclodextrin maximum 5% of the administered activity could be found in blood, and even this only 4 to 10 h following administration. Presumably, beta-cyclodextrin cannot be absorbed either from the stomach or from the small intestine, only the labelled open-chain dextrins and glucose formed from cyclodextrins on amylase action. Therefore it is very likely that the orally administered beta-cyclodextrin cannot provoke toxic symptoms.

Animals↗
PubMed1977

The effect of glypondin on glycogen and protein accumulation in rat organs.

Rats were treated for 21 days with 20, 30 and 40 mg/kg Glypondin dissolved in the drinking water. The weight-increasing effect of Glypondin was studied in rat organs. In the liver a significant rise in the concentration of TCA-soluble glycogen was demonstrated. In the myocardium and m. gastrocnemius the concentration of both the labile and glycogen was unchanged. In the m. gastrocnemius of rats treated with Glypondin a significant rise in the concentration of noncollagenous protein was demonstrated.

Animals↗
PubMed1977

[Organoleptic study of a new dihydrochalcone artificial sweetener].

The compound CH-401-Na (1-[2-hydroxy-4-(3-sulphopropyloxy)phenyl]-3-[3-hydroxy-4-methoxyphenyl]-propanone-1-Na) was studied. Its sweeting power in aqueous solution is 1000 (as compared to that of a 1% sucrose solution); the values for salts formed with 10 other cations range from 750 to 1150. In contrast to the sweet taste of sucrose, that of CH-401-Na is perceived not at the tip of the tongue but at the root of the tongue and at both sides of the oral cavity. It persists for a longer period than that of sucrose. This effect depends to some extent on the cation. The addition of inorganic salts accelerates the extinction of sweet taste. In lemonades, almost 90% of sucrose may be replaced by CH-401-salts. The taste of CH-401-Na is unpleasant in foods having a bitter taste (coffee, cola) and in low-moisture products.

Beverages↗