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Biomedical subjects

J Sweeting

Publications and source records attributed to J Sweeting.

16 recordsLinked to original sources
PubMed1999

Nurses on board.

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Decision Making, Organizational↗
PubMed1998

Iron-rich foci in chronic viral hepatitis.

Stainable iron in the liver (hemosiderosis) is most commonly seen in individuals with homozygous genetic hemochromatosis, prior transfusion, hemolysis, porphyria cutanea tarda, and chronic alcohol-induced liver disease. In chronic viral hepatitis, however, significant hepatocellular hemosiderosis is uncommon. This report describes unusual foci of hepatocellular hemosiderosis ("iron-rich foci" or IRF) in liver biopsy specimens from three patients with chronic hepatitis with or without cirrhosis (two hepatitis C-related, one hepatitis B-related). IRF present within the lobular parenchyma or cirrhotic nodules contrasted sharply with the immediately adjacent hemosiderin-negative liver tissue. Serum iron indices were abnormal in all three patients, but homozygous hemochromatosis was ruled out based on the hepatic iron concentration and hepatic iron index for each case. These cases highlight the potential for irregular iron storage in chronic viral liver disease and possible confusion with genetic hemochromatosis. The possible pathogenesis of IRF and the relationship of iron storage to the outcome of interferon therapy in chronic viral hepatitis are discussed.

Biopsy↗
PubMed1987

Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells.

Concentric hyaline inclusions (Lewy bodies), found in the cytoplasm of pigmented and nonpigmented neurons, are considered characteristic of idiopathic Parkinson's disease. The finding of cytoplasmic inclusions identical to Lewy bodies in ganglion cells of the colonic myenteric plexus in a patient with idiopathic Parkinson's disease and acquired megacolon suggests primary involvement of the enteric nervous system by Parkinson's disease.

Humans↗