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Biomedical subjects

J Sweeney

Publications and source records attributed to J Sweeney.

At least 91 records · Page 5Linked to original sources
PubMed1983

Central catecholamine metabolism in vivo and the cognitive and motor deficits in Parkinson's disease.

Cerebrospinal fluid levels of homovanillic acid (HVA) in unmedicated patients with Parkinson's disease were 45% of levels in control subjects. Levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and platelet monoamine oxidase activity (MAO) did not differ. Within the Parkinson's disease group platelet MAO B activity correlated with HVA (an MAO B substrate) but not MHPG (an MAO A substrate). A mild global dementia was found that did not correlate with the more severe motor deficit. There was a negative correlation between the motor deficit and HVA levels but not with MHPG. Cognitive functioning correlated positively with platelet MAO, and the ratio of HVA to MHPG levels and negatively with MHPG alone. It is postulated that dopaminergic and noradrenergic activity or the functional balance between these systems may contribute to the observed cognitive dysfunction.

Blood Platelets↗
PubMed1983

A comparison of delusional disorders in women and men.

The authors compared delusional disorders in men and women and found that women have more frequent erotic and heterosexual delusions, more affective symptoms, and more interpersonal precipitants and that men have more delusions with a homosexual theme. Perhaps because of these differences in delusional content and affective symptoms, delusional women are more difficult to diagnose within the DSM-III nomenclature than are delusional men. The authors discuss these findings from psychodynamic, ethologic, and sociocultural perspectives and suggest ways of improving DSM-III to make it more representative of female patients.

Adult↗
PubMed1983

Angioleiomyoma.

Angioleiomyoma is a benign tumor that occurs rarely, but it must be considered in the differential diagnosis in patients who have a painful subcutaneous nodule on the lower extremity. The treatment of choice in all cases is surgical excision.

Adult↗
PubMed1983

Effect of perioperative low-dose heparin administration on the course of colon cancer.

There is evidence that drugs that inhibit blood coagulation or platelet activity may retard or prevent the recurrence of cancer in experimental animals and in patients. The data for 230 patients who underwent surgical resection for primary adenocarcinoma of the colon (Dukes B and C) during 1973 to 1977 were studied retrospectively to determine whether low-dose heparin given for prophylaxis of thromboembolism altered the interval to or prevalence of recurrence. Perioperative low-dose subcutaneous heparin was given to 180 patients, and 50 patients received no heparin. The groups were comparable in age, sex, extent of disease, and use of adjuvant chemotherapy or radiation therapy. Disease recurred in 54 of 180 patients (30%) who received heparin and 18 of 50 patients (36%) who did not receive heparin. This difference was not significant (chi2 = 0.6551, P = 0.418). The interval from surgery to recurrence of cancer was slightly longer in the heparin group (790 days) than in the nonheparin group (638 days), but this difference was not statistically significant (P = 0.268). Life table analysis revealed a significantly lower overall mortality rate among patients who received heparin (P less than 0.05), although there was no difference between the two groups in rate of deaths from colon cancer.

Adenocarcinoma↗
PubMed1981

Circulating platelet products in unstable angina pectoris.

In 19 patients with unstable angina pectoris at rest, plasma levels of the platelet-derived proteins beta-thromboglobulin and platelet factor 4 were significantly elevated in blood samples obtained during or within 4 hours after episodes of angina, but were usually normal during quiescent intervals. Plasma levels of the arachidonic acid metabolite thromboxane B2 were less clearly related to angina, and there was no association of angina with levels of the coagulation product fibrinopeptide A. This demonstration of an association of platelet activation and secretion with unstable angina pectoris by radioimmunoassay of circulating platelet constituents offers a new approach to assessment of therapy in ischemic heart disease and suggests that agents that alter platelet function should be evaluated in patients with unstable angina.

Adult↗
PubMedDate not supplied

Increased specificity in measuring satisfaction.

The authors report a patient satisfaction study that addressed some of the methodological limitations of previous studies and attempted to increase the variance in satisfaction assessment by increasing the scope and specificity of inquiry. Same sex patient/therapist match, duration of therapy, individual therapy and treatment with staff social workers rather than psychiatric residents all were positively correlated with increased patient satisfaction. Satisfaction appeared to be a unitary dimension that could be tapped by a global score. Nonetheless, although overall satisfaction was high, one third of patients preferred an alternative treatment.

Adult↗
PubMedDate not supplied

Increased tardive dyskinesia in alcohol-abusing schizophrenic patients.

Many schizophrenics have a diagnosis of substance abuse or dependence. We evaluated whether drug or alcohol abuse is an independent risk factor for tardive dyskinesia (TD) in schizophrenia. In a consecutive admission, clinical study of 75 hospitalized schizophrenics, drug or alcohol abusers had significantly higher TD scores than nonabusers. The association of alcohol abuse or dependence with TD seemed independent from other risk factors for TD.

Adult↗